基本情報
- CAS
359017-79-1- 標準SMILES
Cl.Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21- InChIKey
UUADYKVKJIMIPA-UHFFFAOYSA-N- 分子式
- C32H30ClN5O2
- 平均分子量
- 552.1 g/mol
- 単同位体質量
- 551.2088029
概要
Enzastaurin Hydrochloride is the hydrochloride salt of enzastaurin, a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden.
名称と識別子
- 優先名称
- Enzastaurin Hydrochloride
- IUPAC
- 3-(1-methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-2,5-dione;hydrochloride
- 現地名
- エンザスタウリン塩酸塩
- 英語名
- Unii-kx7K68Z2uh
- 分子式
- C32H29N5O2.ClH
- 分子量
- 552.075
名称と別名
Enzastaurin Hydrochloride359017-79-1Enzastaurin hclEnzastaurin Hydrochloride [USAN]KX7K68Z2UHEnzastaurin monohydrochlorideLY317615 HYDROCHLORIDELY-317615 HYDROCHLORIDEDTXSID70189477ENZASTAURIN HYDROCHLORIDE [MI]ENZASTAURIN HYDROCHLORIDE [JAN]1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-(1-(1-(2-pyridinylmethyl)-4-piperidinyl)-1H-indol-3-yl)-, monohydrochloride
名称をさらに表示
エンザスタウリン塩酸塩エンザスタウリン塩酸塩 (JAN)Ly317615.HClUnii-kx7K68Z2uh3-(1-Methyl-1H-indol-3-yl)-4-{1-[1-(pyridin-2-ylMethyl)piperidin-4-yl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione hydrochloride (1:1)1H-Pyrrole-2,5-dione,3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylMethyl)-4-piperidinyl]-1H-indol-3-yl]-,hydrochloride (1:1)
3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochlorideENZASTAURIN HYDROCHLORIDE [MART.]ENZASTAURIN MONOHYDROCHLORIDE [WHO-DD]ENZASTAURIN HYDROCHLORIDE (MART.)3-(1-METHYL-1H-INDOL-3-YL)-4-(1-(1-(2-PYRIDINYLMETHYL)-4-PIPERIDINYL)-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE HYDROCHLORIDE3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(2-pyridinylmethyl)-4-piperidinyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione Dihydrochloride3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)pyrrole-2,5-dione monohydrochloride3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione Dihydrochloride
物性
構造計算による物性
- 極性表面積
- 72.2 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 4
- 回転可能結合数
- 5
- 重原子数
- 40
- 形式電荷
- 0
- 複雑度
- 974
化学と産業
応用分野
使用(Antineoplastic (protein kinase C inhibitor)ICNI) name for enzacamene is 4-methylbenzylidene.
サプライヤー2 社
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
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