ブロメライン

解説ブロメライン,プロテアーゼの一種で，パイナップル Ananas comosusの果実や根茎に存在する。ペプチドおよびアミド結合の加水分解，エステラーゼ作用，アシルアミノ酸アニリド合成作用などを示す。根茎粉末から水抽出した粗酵素品を精製すると約9%収率で高純度のものが得られる。糖2%を含む一種の糖蛋白質。消炎酵素剤として利用する。古くブロメリン bromelinと呼ばれた酵素は，果実に存在するものに相当する。

使用Bromelain is used as a natural anti-inflammatory for conditions such as arthritis.

使用Bromelain has been found to be used to tenderize meat, chill-proof beer, and produce protein hydrolysates.

一般的な説明Bromelain is a crude extract from pineapple that contains a mixture of different proteases as well as phosphatases, glucosidases, peroxidases, cellulases, glycoproteins, and carbohydrates. Of the different proteases available in a bromelain mixture, commercial bromelain is usually produced from the stem part (stem bromelain), although other pineapple parts contain a certain amount of bromelain as well. Bromelain is an effective anticancer therapeutic agent, as a result of the systemic response to multiple cellular and molecular targets induced by this enzyme; however, the real underlying mechanisms are yet to be fully understood. Also, this enzyme has the potential to be used as an antibiotic since it can modify the permeability of organs and tissues to different drugs. Moreover, bromelain is used in a debridement cream formulation to eliminate burn debris and accelerate the healing process, and can inhibit platelet aggregation, especially for patients affected with heart attack and stroke, and reduce arthritis pathogenesis since it has analgesic properties that can influence pain mediators, and prevent diarrhea by interacting with intestinal secretory signaling pathways. In addition to food and medical applications, bromelain is used in the cosmetic industry to treat various skin conditions. It is also used as a stain remover in teeth cleaning/whitening. In the textile industry, it is used to improve the dyeing properties of protein fibers such as wool and silk and assist in the cocoon-softening process in silk production.