WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P272, P280, P301+P317, P302+P352, P305+P351+P338, P317, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1132) of reports.DangerH302 (91.1%): Harmful if swallowed [Warning Acute toxicity, oral]
規制情報
Chemical: 2-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester2-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 22-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/51872-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester, (dimethylaminoethyl methacrylate): HSNO Approval: HSR001558 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
輸送ラベル（DOT）
Poison
火災危険
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)polymerization hazard]:· Combustible material: may burn but does not ignite readily.Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 68 °C explosive vapour/air mixtures may be formed.
火災の可能性
CombustibleFlammable when exposed to sparks, heat, open flame, or oxidizers.
健康有害性
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)polymerization hazard]:· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death.
有害性の概要
May polymerize on exposure to heat, light, oxidants, reducing agents, or metals causing fire or explosion
A respiratory tract irritant
Corrosive to skin and eyes
[ICSC] A skin, eye, and mucous membrane irritant
In gavage studies of rabbits, electrical brain activity was suppressed followed by clonic-tonic spasms
Highly irritating to skin and eyes, based on animal studies
[HSDB] Heat or contamination can cause exothermic polymerization
Corrosive to eyes and mucous membranes
[CAMEO] Effects in repeated dose feeding studies with rats include late onset chronic convulsions and nerve fiber degeneration in the brain and spinal cord
Corrosive to skin and eyes, based on animal studies
[eChemPortal: SIDSUNEP] Corrosive to skin and eyes
[eChemPortal: ERMA] A skin and eye irritant
May cause skin sensitization
[eChemPortal: ESIS] Danger of skin sensitization
[MAK] A severe irritant that may cause burns
A possible lachrymator and skin sensitizer
[MSDSonline] 2-Dimethylaminoethyl methacrylate (UN2522) has warning of explosive polymerization
[ERG 2016] See ACRYLIC RESINS (MONOMERS).
輸送番号・ガイド（DOT）
2522 153P
反応性グループ
Amines, Phosphines, and Pyridines
EC 分類
Symbol: XnR: 21/22-36/38-43S: (2)-26-28
UN 分類
UN Hazard Class: 6.1UN Pack Group: II
Reactivity Alerts
Polymerizable
Reactivity Profile
2-DIMETHYLAMINOETHYL METHACRYLATE is both an amine and an acrylate ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
消火
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)polymerization hazard]:Use water spray, powder, alcohol-resistant foam, carbon dioxide.
応急処置措置
Fresh air, rest.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .
漏出応急措置
· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
応急処置
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)polymerization hazard]:General First Aid:
安全保管
Separated from metals, oxidants, strong reducing agents and food and feedstuffs. Keep in the dark. Store only if stabilized. Store in an area without drain or sewer access.
Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.To fight fire, use alcohol foam, dry chemical, spray.
保管条件
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature 2 - 8 °C Moisture sensitive. Light sensitive. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials... Storage temperature for ... /dimethylaminoethyl methacrylate/ should not exceed 25 °C in order to avoid the slow build-up of soluble oligomers and polymers.... The methacrylate monomers should not be stored for longer than one year. Shorter storage times are recommended for the aminomethacrylates, ie, three months, and the polyfunctional methacrylates, ie, six months. Many of these cmpd are sensitive to UV light and should, therefore, be stored in the dark. The methacrylic esters may be stored in mild steel, stainless steel, or aluminum. /Methacrylic acid and derivatives/
清掃方法
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.
SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
漏出処分
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
環境中動態
TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 20(SRC), determined from a structure estimation method(2), indicates that N,N-dimethylaminoethyl methacrylate is expected to have very high mobility in soil(SRC). The pKa of N,N-dimethylaminoethyl methacrylate is 8.44(3), indicating that this compound will exist mostly in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of N,N-dimethylaminoethyl methacrylate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(2). N,N-Dimethylaminoethyl methacrylate is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.72 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Using the OECD 301E test, 95.3% degradation was reached in 2 weeks(5) suggesting that biodegradation is an important environmental fate process in soil(SRC). Based on results of the Japanese MITI test which noted abiotic hydrolysis during biodegradation studies(5,6), N,N-dimethylaminoethyl methacrylate may degrade via abiotic hydrolysis in moist alkaline and neutral soils(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 20(SRC), determined from a structure estimation method(2), indicates that N,N-dimethylaminoethyl methacrylate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), an estimated BCF of 2.6(SRC), from a log Kow of 1.13(5) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Using the OECD 301E test, 95.3% degradation was reached in 2 weeks(5) suggesting that biodegradation is an important environmental fate process in water(SRC). The hydrolysis half-life of N,N-dimethylaminoethyl methacrylate at 25 °C was determined to be 4.54 days and 3.31 hours at pH 7 and pH 9 respectively(5)the compound is stable to hydrolysis at pH 4(5). N,N-Dimethylaminoethyl methacrylate is an olefin and olefins in surface waters exposed to sunlight have a half-life on of 25 days(6) .ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N,N-dimethylaminoethyl methacrylate, which has an estimated vapor pressure of 0.72 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N,N-dimethylaminoethyl methacrylate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3.9 hours(SRC), calculated from its rate constant of 9.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase N,N-dimethylaminoethyl methacrylate is also degraded in the atmosphere by reaction with ozone(SRC)the half-life for this reaction in air is estimated to be 24 hours(SRC), calculated from its rate constant of 1.1X10-17 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Based on analogy to a measured nitrate radical rate constant of 4.90X10-15 cu cm/molecule-sec at 25 °C for ethyl methacrylate(3), the atmospheric half-life of N,N-dimethylaminoethyl methacrylate is estimated to be about 6.5 days(SRC).
有害作用
Neurotoxin - Other CNS neurotoxin
毒性の概要
IDENTIFICATION AND USE: N,N-dimethylaminoethyl methacrylate is a colorless liquid with amine-like odor.It is used in binders for coatings, textile chemicals, dispersing agents for nonaqueous systems, antistatic agents, stabilizers for chlorinated polymers, ion exchange resins, emulsifying agents, cationic precipitating agents. It is also used in dental materials, antithrombogenic prosthetics, experimental use in slow-release capsules, in cosmetics. More recently, It is also used in nanoparticles for gene delivery and drug delivery. HUMAN EXPOSURE AND TOXICITY: pH-Sensitive poly(N,N-dimethylaminoethyl methacrylate (DMAEMA)/2-hydroxyethyl methacrylate (HEMA)) nanoparticles were not cytotoxic. ANIMAL STUDIES: Dimethylaminoethyl methacrylate decreased the heart rate and force of contraction of isolated, perfused rabbit heart when added to perfusing liquid. Dimethylaminoethyl methacrylate was strongly irritating to skin of guinea pigs and conjunctiva of rabbits. When administered by gastric gavage to rabbits, dimethylaminoethyl methacrylate initially suppressed brain electrical activity and then induced clonic-tonic spasms. In dogs it produced hypertensive effect following iv administration. The toxicity of 6 acrylates and 6 methacrylates, including N,N-dimethylaminoethyl methacrylate, was determined in rats and fish. All the esters were less toxic than acrylamide and acrylonitrile.
Signs and Symptoms
Cough. Sore throat.Skin burns. Pain.Redness. Pain. Severe deep burns.Abdominal pain. Diarrhoea. Nausea. Vomiting. Burning sensation. Shock or collapse.
ICSC Environmental Data
The substance is harmful to aquatic organisms.
Soil Adsorption/Mobility
Using a structure estimation method based on molecular connectivity indices(1), the Koc of N,N-dimethylaminoethyl methacrylate can be estimated to be 20(SRC). According to a classification scheme(2), this estimated Koc value suggests that N,N-dimethylaminoethyl methacrylate is expected to have very high mobility in soil. The pKa of N,N-dimethylaminoethyl methacrylate is 8.44(3), indicating that this compound will exist mostly in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).
Human Toxicity Excerpts
/OTHER TOXICITY INFORMATION/ pH-Sensitive poly(N,N-dimethylaminoethyl methacrylate (DMAEMA)/2-hydroxyethyl methacrylate (HEMA)) nanoparticles were prepared for the triggered release of paclitaxel within a tumor microenvironment. Tumors exhibit a lower extracellular pH than normal tissues. We show that paclitaxel release from DMAEMA/HEMA particles can be actively triggered by small, physiological changes in pH (within 0.2-0.6 pH units). Monodispersed nanoparticles were synthesized by forming an O/W emulsion followed by photopolymerization. Particles were characterized by transmission electron microscopy, dynamic light scattering, electrophoresis, and cytotoxicity. High release rates and swelling ratios are achieved at low pH, low crosslinking density, and high content of DMAEMA. Paclitaxel release is limited to 9% of the payload at pH 7.4 after a 2-hr incubation at 37 degrees C. After adjusting to pH 6.8, 25% of the payload is released within 2 hr. Cell viability studies indicate that pH-sensitive DMAEMA/HEMA nanoparticles are not cytotoxic and may be used as an efficient, feedback-regulated drug delivery carrier. /Poly(N,N-dimethylaminoethyl methacrylate/
Artificial Pollution Sources
N,N-Dimethylaminoethyl methacrylate's production and use as an intermediate for chemical synthesis and as a monomer in the production of a variety of polymers for water treatment, paper agents, paints, coatings and personal care products(1,2) may result in its release to the environment through various waste streams(SRC).
Environmental Biodegradation
AEROBIC: Using OECD Guideline 301E (Ready biodegradability: Modified OECD Screening Test) and a domestic sewage inoculum, N,N-dimethylaminoethyl methacrylate, at 20 mg/L, was degraded 95.3% after 28 days of incubation which classified the compound as readily biodegradable(1). N,N-Dimethylaminoethyl methacrylate, present at 100 mg/L, reached 89-94% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test (OECD 301C)(1)however, the compound was noted to hydrolyze to N,N-dimethyl-N-ethanolamine and methacrylic acid(1,2). Therefore, the biodegradation results (indicative of being readily biodegradable) correspond with the biodegradability of the hydrolysis products(1).
Environmental Bioconcentration
An estimated BCF of 2.6 was calculated in fish for N,N-dimethylaminoethyl methacrylate(SRC), using a log Kow of 1.13(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Volatilization from Water/Soil
The Henry's Law constant for N,N-dimethylaminoethyl methacrylate is estimated as 1.4X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that N,N-dimethylaminoethyl methacrylate is expected to be essentially nonvolatile from water surfaces(2). N,N-Dimethylaminoethyl methacrylate's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected to occur(SRC). N,N-Dimethylaminoethyl methacrylate is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.72 mm Hg(SRC), determined from a fragment constant method(1).
Non-Human Toxicity Excerpts
/LABORATORY ANIMALS: Acute Exposure/ Dimethylaminoethyl methacrylate decreased the heart rate and force of contraction of isolated, perfused rabbit heart when added to perfusing liquid at concentrations of 1:1000, 1:10,000 or 1:100,000./LABORATORY ANIMALS: Acute Exposure/ 1,2-Diethylaminoethyl methacrylate and 2-dimethylaminoethyl methacrylate were strongly irritating to skin of guinea pigs & conjunctiva of rabbits. Diisopropylaminoethyl methacrylate was nonirritating./LABORATORY ANIMALS: Acute Exposure/ When administered by gastric gavage to rabbits, dimethylaminoethyl methacrylate and diethylaminoethyl methacrylate initially suppressed brain electrical activity and then induced clonic-tonic spasms./LABORATORY ANIMALS: Acute Exposure/ Methacrylic acid admin iv incr respiratory rate, decr heart rate, and produced electrocardiogram changes in anesthetized dogs. Methacrylic acid, methyl, n-propyl, n-butyl, isobutyl, and hydroxyethyl methacrylates produced a biphasic response, an abrupt fall in blood pressure followed by a secondary rise. 2-Ethylhexyl, isodecyl, lauryl, and tert-butylaminoethyl methacrylates produced only a hypotensive effect. Dimethylaminoethylmethacrylate produced only a hypertensive effect.For more Non-Human Toxicity Excerpts (Complete) data for N,N-DIMETHYLAMINOETHYL METHACRYLATE (9 total), please visit the HSDB record page.
