Sulfaguanidine
基本情報
- CAS
61116-95-8- 標準SMILES
NC(N)=NS(=O)(=O)c1ccc(N)cc1- InChIKey
BRBKOPJOKNSWSG-UHFFFAOYSA-N- 分子式
- C7H10N4O2S
- 平均分子量
- 214.25 g/mol
概要
Sulfaguanidine is a sulfonamide incorporating a guanidine moiety used to block the synthesis of folic acid; mostly used in veterinary medicine. It has a role as an antiinfective agent.
名称と識別子
- 優先名称
- Sulfaguanidine
- IUPAC
- 2-(4-aminophenyl)sulfonylguanidine
- 英語名
- 2-(4-aminophenyl)sulfonylguanidine
- 分子式
- C7H10N4O2S
- 分子量
- 0
名称と別名
sulfaguanidine57-67-0SulphaguanidineSulfaguanidinSulfaguineSulfanilylguanidineSulfanilguanidineSulfaguanilSulfoguanidineSulfoguanilSulfoguanyl2-(4-aminophenyl)sulfonylguanidine
名称をさらに表示
Ai3-01048
SulfaguanidinaSulfaguanidinumBenzenesulfonamide, 4-amino-N-(aminoiminomethyl)-SulginumDTXSID1023609NSC-140412-sulfanilylguanidineDTXCID103609
データベース識別子
- CAS
61116-95-8- ChEMBL
CHEMBL338802- ChEBI
CHEBI:94621- UNII
- 15XQ8043FN
- EC Number
- 200-345-9
- Nikkaji
- J2.328K
物性
構造計算による物性
- XLogP
- -0.7
- 極性表面積
- 133 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 4
- 回転可能結合数
- 2
- 重原子数
- 14
- 形式電荷
- 0
- 複雑度
- 307
実験および物理化学的性質
Drugs
Pharmaceuticals -> Antibiotics
Pharmaceuticals -> Antibiotics (Sulfonamide)
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
PesticidesBiocide
LogP-1.22
Solubility>32.1 [ug/mL] (The mean of the results at pH 7.4)
Animal DrugsPharmaceuticals -> Animal Drugs -> Approved in Taiwan
Collision Cross Section149 Ų [M+H]+
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 4.9% (4 of 81) of reports.
Warning
H315 (92.6%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 81 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory Information
Status: Active Update: 26-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23557
Sulphaguanidine: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Benzenesulfonamide, 4-amino-N-(aminoiminomethyl)-: Human health tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (92.6%)
化学と産業
薬理情報
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Mechanism of ActionSulfaguanidine is a sulfonamide antibacterial that inhibits dihydropteroate synthase (DHPS) by acting as a PABA analogue, blocking folate biosynthesis in susceptible microbes.
MeSH Pharmacological ClassificationSubstances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
用途と製造
Use ClassificationPharmaceuticals -> Animal Drugs -> Approved in Taiwan
General Manufacturing InformationBenzenesulfonamide, 4-amino-N-(aminoiminomethyl)-: ACTIVE
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