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α,β-ジチオ二りん酸α,α,β,β-テトラプロピル

Aspon

HCID 18609
ノート反応
基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
3244-90-4
標準SMILES
CCCOP(=S)(OCCC)OP(=S)(OCCC)OCCC
InChIKey
IIDFEIDMIKSJSV-UHFFFAOYSA-N
分子式
C12H28O5P2S2
平均分子量
378.4 g/mol
単同位体質量
378.08534033

名称と識別子

優先名称
Aspon
IUPAC
dipropoxyphosphinothioyloxy-dipropoxy-sulfanylidene-λ5-phosphane
現地名
α,β-ジチオ二りん酸α,α,β,β-テトラプロピル
英語名
ASPON (TM)
分子式
C12H28O5P2S2
分子量
378.43

名称と別名

ASPON3244-90-4Stauffer asp-51Tetra-n-propyl dithiopyrophosphateO,O,O,O-Tetrapropyl dithiopyrophosphateASP 51Caswell No. 845ATetrapropyldithiodifosfatTetrapropyl dithiopyrophosphateENT 16,894Tetrapropyl thiodiphosphateNSC 2550
名称をさらに表示
アスポンα,β-ジチオ二りん酸α,α,β,β-テトラプロピルCS_N-11103-10MG_アスポンアスポン STANDARDアスポン Standard, 100 µg/mL in MethanolA-42O,O-ジプロピル {[ジプロポキシ(スルファニリデン)-λ5-ホスファニル]オキシ}ホスホノチオアートa42e8573ASP-51NSC2550NSC-2550ent16,894ASPON (TM)staufferasp-51
E 8573HSDB 1776Tetrapropyldithiodifosfat [Czech]Thiopyrophosphoric acid, tetrapropyl esterTetrapropyl thiopyrophosphateEINECS 221-817-0UNII-PC55IL137PEPA Pesticide Chemical Code 079101

データベース識別子

CAS
3244-90-4
PubChem CID
18609
DTXSID
DTXSID6032510
UNII
PC55IL137P
EC Number
221-817-0
Nikkaji
J7.697J

物性

構造計算による物性

XLogP
6
極性表面積
110 Ų
水素結合供与体数
0
水素結合受容体数
7
回転可能結合数
14
重原子数
21
形式電荷
0
複雑度
299

実験および物理化学的性質

Pesticides · 2 件

Pesticides -> Organophosphate Insecticides

Pesticide (Aspon) -> USDA PDB

OdorTechnical product (93-96% pure) has a faint aromatic odor.
DensityDensity at 20 °C/20 °C = 1.119-1.123 (Technical product, 93-96% pure)
Color/FormTechnical product (93-96% pure) is a straw to amber-colored liquid.
Solubility · 3 件

FP: BELOW 5 °C; SPARINGLY SOL IN LIGHT PETROLEUM; MISCIBLE WITH MOST ORGANIC SOLVENTS /TECHNICAL PRODUCT/

Solubility in water at 20 °C is 30 mg/l water (Technical product, 93-96% pure).

Miscible with acetone, ethanol, kerosene, 4-methylpentan-2-one, xylene (Technical product, 93-96% pure)

CorrosivityCorrosive to steel (Technical product, 93-96% pure)
Flash Point · 2 件

149 °C

149 °C (OPEN CUP) /TECHNICAL PRODUCT/

Boiling Point170 °C at l.0 mm Hg (Technical product, 93-96% pure)
Vapor Pressure · 2 件

0.0000107 [mmHg]

The vapor pressure at 25 °C is 13 mPa (Technical product, 93- 96% pure)

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 6 件

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P273, P280, P301+P317, P302+P352, P317, P321, P330, P362+P364, P391, and P501 (click each P-code to see the statement)

Warning

H302+H312 (92.9%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]

P264, P270, P273, P280, P301+P317, P302+P352, P317, P321, P330, P362+P364, P391, and P501 (click each P-code to see the statement)

危険有害性情報

Hazards Summary · 1 件

Depressed cholinesterase activity in 90-day feeding study of rats at doses below lethal levels; Showed no evidence of mutagenicity; [HSDB] Effects in high-dose animal studies include convulsions and inhibition of true cholinesterase; [RTECS] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

FIFRA Requirements · 1 件

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Aspon is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0019; Pesticide type: Insecticide; Registration Standard Date: 09/01/80; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Aspon; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

化学と産業

薬理情報

Mechanism of ActionPARATHION & ITS RELATIVES ARE KNOWN TO INHIBIT ENZYME CHOLINESTERASE IN ALL PARTS OF THE BODY BY PHOSPHORYLATING THE ACTIVE SITE. /PARATHION/

用途と製造

Uses · 6 件

Used as insecticide and acaricide to protect lawns and turf; [HSDB]

Cancelled--no longer registered as a pesticide for use in the US; [HSDB]

Farming (Pesticides) [Category: Industry]

The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

INSECTICIDE /FORMER USE/

ACARICIDE /FORMER USE/

U.S. Exports · 2 件

(1972) No Data

(1975) No Data

U.S. Imports · 2 件

(1972) No Data

(1975) No Data

U.S. Production(1974) 2.27X10+8 G (CONSUMPTION)
Consumption PatternsESSENTIALLY 100% AS AN INSECTICIDE FOR SOD WEBWORMS & CINCHBUGS ON LAWN & TURF
Methods of ManufacturingREACTION OF O,O-DI-N-PROPYL PHOSPHOROCHLORIDOTHIOATE WITH WATER, IN THE PRESENCE OF PYRIDINE
Formulations/Preparations · 4 件

'ASPON', EMULSIFIABLE CONCENTRATE (480 G ACTIVE INGREDIENT/L); GRANULES (50 G/KG).

WETTABLE POWDER (25%); EMULSIFIABLE CONCENTRATE (85%), (6 LB/GAL)...

Technical product is 93-96% pure.

'Aspon E', EC(240 or 720 g a.i./l); 'Aspon 5GA', 'Aspon 25G', Aspon 25G', GR(50 or 250 g/kg)

General Manufacturing Information · 3 件

/IT IS/...PROTECTED BY US PATENT 2663722.

COMPATIBLE WITH COMMONLY-USED PEST CONTROL MATERIALS. CONSIDERABLE CONTACT & FUMIGANT INSECTICIDAL PROPERTY, ESPECIALLY AGAINST APHIDS--SOME RESIDUAL ACTIVITY. ACTIVE AGAINST CINCH BUGS, BLISSUS SPECIES, IN EASTERN USA. RECOMMENDED FOR USE ON TURF. NO PHYTOXICITY REPORTED AT INSECTICIDAL CONCENTRATIONS.

関連反応

0 件
反応記録を作成

現在のフィルター条件では反応記録がありません。

化合物ノート

読み込み中…

このページの内容基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
Refractive IndexIndex of refraction is 1.471 at 21 °C/D (Technical product, 93-96% pure).
Physical DescriptionStraw to amber-colored liquid; [HSDB] Amber liquid; [MSDSonline]
Stability/Shelf LifeSTABLE WITH INSIGNIFICANT HYDROLYSIS IN WATER AT ROOM TEMP; STABLE FOR AT LEAST 24 HR @ 100 °C, BUT DECOMP, WITHOUT EXPLOSIVE HAZARD @ 149 °C; DISCOLORATION & PHYSICAL CHANGES MAY OCCUR ON PROLONGED CONTACT WITH METAL /TECHNICAL/

物理化学的性質

融点
-44.9 °C · -44.9°C
沸点
381.6 · 381.6±25.0 °C(Predicted)
比重(密度)
1.12 · 1.1200
闪点
149 °C · 149 °C
外見
液体
Henry's Law Constant
6.1 · 6.1×100 mol/(m3Pa) at 25℃, Ebert et al. (2023)
EPAの化学物質情報
Tetrapropyl dithiopyrophosphate (3244-90-4)

化学的性質

化学的特性ASPON (TM) is amber liquid. Miscible with most organic solvents; insoluble in water.

Hazard Classes and Categories · 3 件

Acute Tox. 4 (100%)

Acute toxicity - category 4

Acute Tox. 4 *

安全と保護具

Exposure Control and Personal Protection · 1 件

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Disposal Methods · 1 件

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

毒性情報

Adverse EffectsOther Poison - Organophosphate
Human Toxicity Excerpts · 2 件

SYMPTOMATOLOGY: 1. NAUSEA...VOMITING, ABDOMINAL CRAMPS, DIARRHEA, EXCESSIVE SALIVATION... 2. HEADACHE, GIDDINESS, VERTIGO & WEAKNESS. 3. RHINORRHEA & SENSATION OF TIGHTNESS IN CHEST ARE COMMON IN INHALATION EXPOSURE. 4. BLURRING OR DIMNESS OF VISION, MIOSIS... TEARING, CILIARY MUSCLE SPASM, LOSS OF ACCOMMODATION & OCULAR PAIN... MYDRIASIS...SOMETIMES SEEN...PROBABLY DUE TO SYMPATHO-ADRENAL DISCHARGE. 5. LOSS OF MUSCLE COORDINATION, SLURRING OF SPEECH, FASCICULATIONS & TWITCHING OF MUSCLES (PARTICULARLY OF TONGUE & EYELIDS), & GENERALIZED PROFOUND WEAKNESS. 6. MENTAL CONFUSION, DISORIENTATION & DROWSINESS. /PARATHION/

SYMPTOMATOLOGY: 7. DIFFICULTY IN BREATHING, EXCESSIVE SECRETION OF SALIVA & OF RESP TRACT MUCUS, ORONASAL FROTHING, CYANOSIS, PULMONARY RALES & RHONCHI & HYPERTENSION, (PRESUMABLY DUE TO ASPHYXIA). 8. RANDOM JERKY MOVEMENTS, INCONTINENCE, CONVULSIONS, & COMA. 9. DEATH PRIMARILY DUE TO RESP ARREST ARISING FROM FAILURE OF RESP CENTER, PARALYSIS OF RESP MUSCLES, INTENSE BRONCHOCONSTRICTION OR ALL THREE. /PARATHION/

Non-Human Toxicity Excerpts · 3 件

IN 90-DAY FEEDING TRIALS AT SUBLETHAL RATES RATS SHOWED DEPRESSION OF RED BLOOD CELL CHOLINESTERASE.

REPORTED TO BE ANTICHOLINESTERASE OF LOW MAMMALIAN TOXICITY. ...GROWTH OF RATS GIVEN /ORALLY/ 25 MG/KG DAILY IS INHIBITED.

FOURTEEN PESTICIDES INCL ASPON WERE EVALUATED FOR MUTAGENIC POTENTIAL. THE MICROBIAL ASSAY SYSTEMS USED WERE THE HISTIDINE REVERSE MUTATION SYSTEM IN 5 STRAINS OF SALMONELLA TYPHIMURIUM (TA1535, TA1537, TA1538, TA98, & TA100), THE TRYPOTPHAN MUTATION SYSTEM IN ESCHERICHIA COLI WP2, & THE MITOTIC RECOMBINATION ASSAYS IN SACCHAROMYCES CEREVISIAE D3. A MAMMALIAN METABOLIC ACTIVATION SYSTEM USING LIVER OF RATS THAT HAD BEEN TREATED WITH AROCLOR 1254 WAS USED IN ALL ASSAYS. ASPON WAS NONMUTAGENIC. RESULTS OF OTHER CHEMICALS ARE GIVEN.

法規制情報

FIFRA Requirements · 1 件

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Aspon is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0019; Pesticide type: Insecticide; Registration Standard Date: 09/01/80; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Aspon; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

安全データ

rtecs
XN4550000
ridadr
3018
毒性
Acute oral LD50 for rats 450 mg/kg (RTECS, 1985).
risk_code
21/22-50/53
hazard_code
Xn,N
safety_code
36/37-60-61
hazard_class
6.1(b)
packing_group
III
有毒物質データの
3244-90-4(Hazardous Substances Data)

Aspon's registration has been cancelled

応用分野

使用ASPON (TM) is an organophosphorus, nonsystemic insecticide used to control chinch bugs in lawns

サプライヤー15 社

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