基本情報
- CAS
1867-73-8- 標準SMILES
CNc1ncnc2c1ncn2C1OC(CO)C(O)C1O- InChIKey
VQAYFKKCNSOZKM-UHFFFAOYSA-N- 分子式
- C11H15N5O4
- 平均分子量
- 281.27 g/mol
- 単同位体質量
- 281.11240398
概要
Adenosine, N-methyl- is a purine nucleoside.
名称と識別子
- 優先名称
- N-Methyl-9-pentofuranosyl-9H-purin-6-amine
- IUPAC
- 2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolane-3,4-diol
- 現地名
- N-メチルアデノシン
- 英語名
- 6-Methylaminopurine 9-ribofuranoside
- 分子式
- C11H15N5O4
- 分子量
- 281.27
名称と別名
n-methyl-9-pentofuranosyl-9h-purin-6-amineRefChem:1091905DTXCID80209074DTXSID90859685NSC 294096-Methyladenosine;N-Methyladenosine6-Methylaminopurine 9-ribofuranosideNSC627045N6-Me-AdenosineOprea1_576536SCHEMBL23647923CHEBI:182179
名称をさらに表示
6-メチルアミノプリンリボシドN6-メチルアデノシンN-メチルアデノシンメチル-6-アデノシン(2R,3S,4R,5R)-2-(ヒドロキシメチル)-5-[6-(メチルアミノ)-9H-プリン-9-イル]オキソラン-3,4-ジオールN6-METHYLADENOSINECS-1297N6-Me-AN6-Me-rAN6-Me-ArNSC-29409N-MethyladenosineAdenosine, N-methyl-N6,N6-Methyladenosin
VQAYFKKCNSOZKM-UHFFFAOYSA-NHMS3373K08HMS3652E11NSC29409NSC971132-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolane-3,4-diolNSC-97113NSC409168
データベース識別子
- CAS
物性
構造計算による物性
- XLogP
- -0.4
- 極性表面積
- 126 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 8
- 回転可能結合数
- 3
- 重原子数
- 20
- 形式電荷
- 0
- 複雑度
- 349
物理化学的性質
- 融点
- 172 °C · 172 °C
- 沸点
- 649.1 · 649.1±65.0 °C(Predicted)
- 比重(密度)
- 1.85 · 1.85±0.1 g/cm3(Predicted)
- 貯蔵温度
- 2 · Keep in dark place,Sealed in dry,2-8°C
- 溶解性
- DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- 酸解離定数(Pka)
- 13.12 · 13.12±0.70(Predicted)
- 外見
- Powder
- 色
- White to off-white
- PH
- 4 · 4.0
- 安定性
- Hygroscopic
- InChI
- InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7-,8-,11-/m1/s1
- InChIKey
- VQAYFKKCNSOZKM-IOSLPCCCSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC)N=C2)[C@H](O)[C@@H]1O
化学と産業
応用分野
説明N6-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.
使用N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.
上流・下流製品情報
下流製品
サプライヤー100 社
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
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湖北威德利化学试剂有限公司186-02735115 18062128043 · [email protected]
艾吉析科技（上海）有限公司
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