3,9-ビス(オクタデシルオキシ)-2,4,8,10-テトラオキサ-3,9-ジホスファスピロ[5.5]ウンデカン

Liquid; Large Crystals

White waxy flakes; [MSDSonline]

This chemical does not meet GHS hazard criteria for 38% (101 of 266) of reports.

Danger

H340 (14.3%): May cause genetic defects [Danger Germ cell mutagenicity]；H360 (14.3%): May damage fertility or the unborn child [Danger Reproductive toxicity]；H413 (43.6%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

P203, P273, P280, P318, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 266 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 101 of 266 reports by companies.；There are 3 notifications provided by 165 of 266 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis(octadecyloxy)-

2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis(octadecyloxy)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis(octadecyloxy)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 18-02-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11711

2,4,8,10-Tetraoxa-3,9-diphosphaspiro5.5undecane, 3,9-bis(octadecyloxy)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

The U.S. high production volume (HPV) chemicals are those which are manufactured in or imported into the United States in amounts equal to or greater than one million pounds per year. Robust Summaries include health effects, ecotoxicity data, and environmental fate information for selected chemicals. EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans. Available from: http://www.epa.gov/chemrtk/viewsrch.htm on 2,4,8,10-tetraoxa-3,9-diphosphaspiro(5.5)undecane,3,9-bis(octadecyloxy)- as of November 3, 2004.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

/LABORATORY ANIMALS: Acute Exposure/ /Following application of 10% distearyl pentaerythritol diphosphite in cottonseed oil to the eyes of 6 rabbits/ ...the test material produced a very mild conjunctival effect in two of the animals which cleared by the second day of observation.

/LABORATORY ANIMALS: Acute Exposure/ /Following 2000 mg/kg distearyl pentaerythritol diphosphite applied to the dermis of ten white New Zealand rabbits/ ... the test material induced very slight to moderate erythema on all rabbits and very slight edema on eight rabbits. Desquamation was present on 8 sites by day 7 and one site by day 14. There were no other dermal findings. Three sites had very slight erythema and/or desquamation at study termination (day 14).

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ /In a 90 day dietary study, Charles River albino rats were exposed to /Distearyl Pentaerythritol Diphosphite/ at concentrations of 0, 300, 1000, 3000 ppm/ ... Statistical comparisons of final body weights and total weight gains revealed no significant differences between test and control rats. ... The only statistically significant difference reported was the liver/body weight ratio for the 3000 ppm males. The authors of the study concluded that the lack of any consistent dietary or sex-related response indicates that the intergroup differences were not related to treatment. ... Six deaths occurred during the study. All of these deaths resulted from trauma incurred during the collection of blood samples. These deaths occurred in the control as well as the test groups and were not attributed to the ingestion of the test material. ... All of the lesions noted in the microscopic examination of tissues were those of spontaneous disease and are not unusual for the albino rat. The most frequent findings were lesions in the trachea and lungs, indicating chronic murine pneumonia. These occurred in the control as well as the treated rats.

/GENOTOXICITY/ /In a micronucleus assay, male and female ICR mice were exposed to ip doses of /distearyl pentaerythritol diphosphite/ of 0, 500, 1000, 2000 mg/kg bw for 24 or 48 hr./ The test article was judged negative /with/ no statistically significant increase in micronucleated polychromatic erythrocytes above the concurrent vehicle control values and no evidence of dose responses were observed at any sampling time ...

/GENOTOXICITY/ /Distearyl pentaerythritol diphosphite/ was negative in the Ames test using Salmonella strains TA 97, TA 98, TA 100, TA 102 and E. coli WP2/pKM101 at concentrations 0, 0.05, 0.1, 0.2, 9.5 ug/plate with and without metabolic activation. ... Under /study/ conditions, there was neither an increase in number of revertant cells, nor any toxicity.

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

LD50 Rabbit dermal >2,000 mg/kg

LD50 Rat oral >1,000 mg/kg

Chemical: 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis(octadecyloxy)-

2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis(octadecyloxy)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis(octadecyloxy)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 18-02-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11711

2,4,8,10-Tetraoxa-3,9-diphosphaspiro5.5undecane, 3,9-bis(octadecyloxy)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Used as a color and molecular weight stabilizer for polyolefins, polyesters, elastomers, styrenics, engineering thermoplastics, and adhesive formulations; Also used as a commercial antioxidant; [HSDB]

Working with Glues and Adhesives [Category: Other]

O,O'dioctadecylpentaerythritol bis(phosphite) (Weston 618) is used as a color and molecular weight stabilizer for polyolefins, polyesters, elastomers, styrenics, engineering thermoplastics and adhesive formulations.

Commercial antioxidant. /From table/

Plastics -> Typical concentration range in plastic materials -> 0.2%

2023: 1,000,000 - <2,500,000 lb；2022: 1,000,000 - <2,500,000 lb；2021: 2,500,000 - <4,000,000 lb；2020: 2,500,000 - <4,000,000 lb

2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis(octadecyloxy)- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).[EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program. 2,4,8,10-Tetraoxa-3,9-diphosphaspiro

Plastics -> Polymer Type -> Polyolefin-I; Polyolefin-II

Plastics -> Antioxidants

Synthetic Rubber Manufacturing；Plastics Product Manufacturing；Plastics Material and Resin Manufacturing

2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis(octadecyloxy)-: ACTIVE