基本情報
- CAS
3810-74-0- 標準SMILES
CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]3N=C(N)N)O[C@@H](C)[C@]2(O)C=O)O[C@@H](CO)[C@H](O)[C@H]1O.CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]3N=C(N)N)O[C@@H](C)[C@]2(O)C=O)O[C@@H](CO)[C@H](O)[C@H]1O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
QTENRWWVYAAPBI-YCRXJPFRSA-N- 分子式
- C42H84N14O36S3
- 平均分子量
- 1,457.4 g/mol
- 単同位体質量
- 1,456.4334786
概要
Streptomycin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.
名称と識別子
- 優先名称
- Streptomycin Sulfate
- IUPAC
- bis(2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine);sulfuric acid
- 現地名
- ストレプトマイシン硫酸塩
- 英語名
- Streptomycin sulfate
- 分子式
- C21H41N7O16S
- 分子量
- 679.65
名称と別名
Streptomycin sulfateStreptomycin sulphate3810-74-0StrepcinStrycinVetstrepAmbistryn SAgri-StrepAgrimycin sulfateAgrimycin 17Streptomycin A sulfateStreptorex
名称をさらに表示
ストレプトマイシン硫酸塩アグリストレプアンビストリンSストレプトマイシンセスキスルファート硫酸ストレプトマイシンアグリマイシン17ストレプトネックス4-O-[2-O-[2-(メチルアミノ)-2-デオキシ-α-L-グルコピラノシル]-5-デオキシ-3-ホルミル-α-L-リキソフラノシル]-N,N'-ビス(アミノイミノメチル)-D-ストレプタミン·3/2硫酸塩ストレプトマイシンA硫酸塩ベトストレプストリシンストレプトマイシン硫酸塩標準品ストレプトマイシン硫酸ストレプトマイシン硫酸塩 [タンパク質研究用]ストレプトマイシン3/2硫酸塩 水和物ストレプトマイシン硫酸塩, ストレプトマイセス属由来ストレプトマイシン 硫酸塩ストレプトマイシン 溶液ストレプトマイシンセスキ硫酸塩 水和物ストレプトマイシン硫酸塩 (JP17)Streptomycin Sulphate Sterile
物性
構造計算による物性
- 極性表面積
- 922 Ų
- 水素結合供与体数
- 30
- 水素結合受容体数
- 42
- 回転可能結合数
- 18
- 重原子数
- 95
- 形式電荷
- 0
- 複雑度
- 1,020
実験および物理化学的性質
Solubilitygreater than or equal to 0.1 mg/mL at 64 °F (NTP, 1992)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Physical DescriptionStreptomycin sulfate (2:3) (salt) appears as an antibacterial. White to light gray or pale buff powder with faint amine-like odor.
物理化学的性質
- 融点
- 185 °C · >185°C (dec.)
- 比旋光度
- -79 · -79~-88°(20℃/D)(c=1,H2O)(calculated on the dried basis)
- 比重(密度)
- 1.2302 · 1.2302 (rough estimate)
- 屈折率
- -85 ° · -85 ° (C=1, H2O)
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- 2 O: · H2O: 0.1 g/mL、透明
- 外見
- 粉
- 色
- ホワイトからオフホワイト
- PH
- pH (100g/l, 25℃) : 4.5～7.0
- 水溶解度
- 0.01 g/100 · >=0.01 g/100 mL で 18 ºC
- Merck
- 14 · 14,8826
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 0.3% (1 of 303) of reports.
Danger
H302 (43.9%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 303 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory Information
Chemical: D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-formyl-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3)(salt)
Hazard Traits - Developmental Toxicity
Streptomycin Sesquisulfate is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)
Streptomycin sesquisulphate: Does not have an individual approval but may be used under an appropriate group standard
Fire HazardsFlash point data for this chemical are not available, however it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to this compound include skin rashes, eosinophilia, blood dyscrasias, stomatitis, anaphylactic shock, pruritus, scaling, and fever. (NTP, 1992)
Reactive GroupAlcohols and Polyols
Reactivity ProfileSTREPTOMYCIN SULFATE (2:3) (SALT) is a medicinal amino saccharide.
Air and Water ReactionsHygroscopic. Water soluble.
化学と産業
薬理情報
MeSH Pharmacological Classification
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Substances that inhibit the growth or reproduction of BACTERIA.
用途と製造
Household ProductsInformation on 1 consumer products that contain Streptomycin sulfate in the following categories is provided:
General Manufacturing InformationD-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-formyl-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3): ACTIVE
応用分野
用途酢酸菌や好熱菌などから酵素精製の際の除核酸、遺伝子工学研究用。
用途アミノグリコシド系抗生物質 です。細菌リボソーム 30S に結合し、タン パク質合成阻害作用を示します。グラム陽性・ 陰性菌に対して抗菌力を示します。
説明Streptomycin was found in the culture broth of Streptomyces griseus by S. A. Waksman of Rutgers University in 1944; it was the second antibiotic introduced clinically (after penicillin). This drug is a water soluble, basic substance having an aminoglycoside structure and showing strong activity against a wide range of gram-positive and gram-negative bacteria including Mycobacterium. Streptomycin is the first choice among antituberculotic antibiotics and has been used for the therapy of Spirochaeta and Treponema infections.
使用Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor. Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis.
An antibacterial. White to light gray or pale buff powder with faint amine-like odor.
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