基本情報
- CAS
142852-50-4- 標準SMILES
O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2c(c1)NCCCC2- InChIKey
PMBLXLOXUGVTGB-UHFFFAOYSA-N- 分子式
- C25H32N2O
- 平均分子量
- 376.5 g/mol
- 単同位体質量
- 376.25146365
概要
Zanapezil is a member of piperidines.
名称と識別子
- 優先名称
- Zanapezil
- IUPAC
- 3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one
- 英語名
- ZANAPEZIL
- 分子式
- C25H32N2O
- 分子量
- 376.53
名称と別名
Zanapezil142852-50-4Zanapezil [INN]3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-oneZanepezilzanapeziloUNII-0A0800O89N0A0800O89N1-Propanone, 3-(1-(phenylmethyl)-4-piperidinyl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-zanapezilumzanapezil funarateRefChem:195842
名称をさらに表示
TAK-147 free base1-Propanone, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-
Zanapezil (free base)Zanapezil free baseCHEMBL750133-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-yl)propan-1-oneNCGC00183005-01SCHEMBL678642orb1691710SCHEMBL29366424
データベース識別子
- CAS
142852-50-4- PubChem CID
- 198752
- DTXSID
DTXSID90861521- ChEMBL
CHEMBL75013- ChEBI
CHEBI:188916- UNII
- 0A0800O89N
- Nikkaji
- J606.548A
物性
構造計算による物性
- XLogP
- 4.9
- 極性表面積
- 32.3 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 3
- 回転可能結合数
- 6
- 重原子数
- 28
- 形式電荷
- 0
- 複雑度
- 479
実験および物理化学的性質
DrugsPharmaceuticals -> Listed in ZINC15
物理化学的性質
- 外見
- Solid
- 色
- White to light yellow
化学と産業
薬理情報
Pharmacodynamics
Zanapezil is an acetylcholinesterase inhibitor being developed by Takeda for the treatment of dementia in subjects with Alzheimer’s disease. In May 2003, the company discontinued development of the compound due to a lack of a dose-dependent effect in the trials.
Mechanism of Action
Zanapezil inhibits the degradation of acetylcholine, a neurotransmitter, to prevent the reduction of cerebral acetylcholine levels and to enhance the mental function of patients with dementia. It is expected to act selectively on the central nervous system, resulting in fewer peripheral adverse reactions.
応用分野
使用Zanapezil is a acetylcholinesterase inhibitor that is a potential drug for treating Alzheimer disease.
上流・下流製品情報
上流原料
サプライヤー3 社
上海立崎生物医学研究中心18014399201 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
ChemeGen 中国18818260767 · [email protected]
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