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CRYSTALS FROM 1,1,2-TRICHLOROETHANE + HEXANE (1:2)

WHITE CRYSTALLINE POWDER OR CLEAR, VISCOUS LIQ WHICH MAY CONGEAL TO SOLID ON STANDING

CONCURRENT INGESTION OF MEPROBAMATE & ALCOHOL CAN LEAD TO ENHANCEMENT OF THEIR CNS DEPRESSANT EFFECTS. ...TYBAMATE /IS/...CHEMICALLY & PHARMACOLOGICALLY RELATED TO MEPROBAMATE...

GRAND MAL OR PETIT MAL CONVULSIONS HAVE BEEN REPORTED IN FEW HOSPITALIZED PSYCHOTIC PT WHO RECEIVED LARGE DOSES OF TYBAMATE & PHENOTHIAZINES CONCOMITANTLY.

ACUTE NONTHROMBOCYTOPENIC PURPURA HAS ALSO BEEN REPORTED, & ANGIOEDEMA & BRONCHOSPASM HAVE OCCASIONALLY OCCURRED. ...ASSOC WITH DEVELOPMENT OF APLASTIC ANEMIA, THROMBOCYTOPENIA, LEUKOPENIA, AGRANULOCYTOSIS, & ERYTHROID HYPOPLASIA; NUMBER OF REPORTED CASES HAS BEEN VERY SMALL. /MEPROBAMATE/

MAJOR SIDE EFFECTS...ARE SLEEPINESS & ATAXIA, HYPOTENSION MAY OCCUR. ALLERGIC REACTIONS HAVE BEEN REPORTED IN FROM 0.2-3.4% OF DIFFERENT SERIES OF PT & APPEAR MOST FREQUENTLY IN THOSE WITH HISTORY OF DERMATOLOGICAL OR ALLERGIC CONDITIONS. URTICARIA OR ERYTHEMATOUS RASH IS MOST COMMON MANIFESTATION. /MEPROBAMATE/

EXACERBATION OF ACUTE INTERMITTENT PORPHYRIA...MAY BE CAUSED... SUICIDE ATTEMPTS...ARE NOT UNCOMMON. ... COMA, LOW BLOOD PRESSURE, SHOCK, PULMONARY EDEMA, & RESPIRATORY DEPRESSION CHARACTERIZE MASSIVE OVERDOSAGE. /MEPROBAMATE/

...GLOSSITIS...PRURITUS ANI...CONFUSION, DEPERSONALIZATION, & "PANIC REACTION" OCCUR OCCASIONALLY.

...DIZZINESS, SLURRED SPEECH, HEADACHE, VERTIGO, WEAKNESS, PARESTHESIAS, IMPAIRED VISUAL ACCOMMODATION, EUPHORIA, OVER-STIMULATION & PARADOXICAL EXCITEMENT...NAUSEA, VOMITING, & DIARRHEA...PALPITATION, ARRHYTHMIAS, SYNCOPE, & HYPOTENSIVE CRISES... /MEPROBAMATE/

Compounds capable of relieving pain without the loss of CONSCIOUSNESS.

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.

Drugs used to cause dilation of the blood vessels.

...WELL ABSORBED FROM GI TRACT... MEPROBAMATE IS QUITE UNIFORMLY DISTRIBUTED IN BODY, & ABOUT 10% OF DRUG IS EXCRETED IN UNCHANGED FORM IN URINE. /MEPROBAMATE/

ABSORPTION OF [(14)C]-TYBAMATE...FROM GI TRACT WAS FAIRLY RAPID IN RATS RECEIVING ORAL DOSE. 67% OF (14)C REMAINED THERE 2 HR LATER, WHEREAS ONLY 21% REMAINED 4 HR LATER. 21% WAS EXCRETED IN 2-HR URINE. 24 HR AFTER IP DOSE, RATS HAD EXCRETED 87% OF (14)C IN URINE, 5% IN FECES...3% WAS PRESENT IN INTESTINAL CONTENTS.

IN PREGNANT MICE, TYBAMATE SLOWLY CROSSED PLACENTA, & LEVELS OF (14)C WERE LOWER IN FETUS THAN IN MOTHER. 30 MIN AFTER RECTAL ADMIN...MUCH (14)C WAS PRESENT IN LIVER & INTESTINES. RAPID PENETRATION...INTO BRAIN & ADIPOSE TISSUE WOULD BE EXPECTED FOR THIS LIPID-SOL DRUG.

WHOLE-BODY AUTORADIOGRAPHY OF MICE RECEIVING IV DOSES...SHOWED THAT (14)C WAS PRESENT IN CNS WITHIN 50 SEC, & LEVELS WERE ALSO HIGH IN ADIPOSE TISSUE, MYOCARDIUM, SALIVARY GLANDS, & KIDNEYS. AFTER 10 MIN...(14)C IN BRAIN HAD DECR, BUT WERE HIGH IN LIVER, INTESTINES, & KIDNEYS, ORGANS CONCERNED WITH EXCRETION OF TYBAMATE.

TYBAMATE (SOLACEN, TYBATRAN), 125, 250, 350 MG CAPSULES.

INJECTION USP: 400 MG/5 ML; ORAL SUSPENSION NF: 200 MG/5 ML; TABLETS USP: 200 & 400 MG.