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基本情報
- CAS
18660-81-6- 標準SMILES
NC1=N[C@H](O)[C@H]2[C@@H]3O[C@@]4(O)O[C@H]([C@H](O)C2(N1)[C@@H]4O)[C@]3(O)CO.O=C(O)CC(O)(CC(=O)O)C(=O)O- 分子式
- C11H17N3O8.C6H8O7
- 平均分子量
- 511.39 g/mol
名称と識別子
- 優先名称
- TETRODOTOXIN CITRATE
- 現地名
- テトロドトキシンくえん酸塩
- 英語名
- TETRODOTOXIN CITRATE
- 分子式
- C11H17N3O8.C6H8O7
- 分子量
- 511.39
名称と別名
テトロドトキシンくえん酸塩TTX・くえん酸塩テトロドトキシンTETRODOTOXIN CITRATEcitratodetetrodotoxinatetrodotoxin,citrate(1:1)(salt)Tetrodotoxin(TTX), with citrateCitrato de tetrodotoxina [spanish]Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci)Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitratOCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE(5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)
データベース識別子
- CAS
18660-81-6- PubChem CID
- 205806
物性
物理化学的性質
- 貯蔵温度
- -20 °C · Desiccate at -20°C
- 溶解性
- Citrate Buffer (pH 4.8): 30 mg/ml (100 mM)
- 外見
- A solid
- 酸解離定数(Pka)
- 8.76 · 8.76(at 25℃)
- 水溶解度
- 100 mM · Soluble to 100 mM in water
- 安定性
- Unstable in Acidic solution, Unstable In Acidic Solution
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
安全データ
- rtecs
- IO1450000
- 毒性
- A toxin contained in the ovary and liver of puffer fish, in the eggs of the California newt and in some other animals. It is used as a chemical tool for the study of ion channels. The s.c. LD50 in mice is 10 mg/kg. It is a toxicant of nerve and muscle by blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and hypotension. There is no antidote. Therapy involves artificial respiration.
- risk_code
- 26/27/28
- hazard_code
- T+
- safety_code
- 22-36/37/39-45
化学と産業
応用分野
解説フグ毒とよばれるが，タコ，ハゼ，イモリからも見出されている．実際に海洋細菌によって合成されている．LD50は10μg/kg．最近この毒を含まないフグが養殖され話題を集めた．
説明TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Nav) channels, blocking nerve and muscle action potentials. It inhibits the Nav current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM. TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the Nav current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain. This citrate-stabilized form of TTX is designed for improved solubility over pure TTX , which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized.
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