基本情報
- CAS
1425-61-2- 標準SMILES
CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]3N=C(N)N)O[C@@H](C)[C@]2(O)CO)O[C@@H](CO)[C@H](O)[C@H]1O.CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]3N=C(N)N)O[C@@H](C)[C@]2(O)CO)O[C@@H](CO)[C@H](O)[C@H]1O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
CZWJCQXZZJHHRH-YCRXJPFRSA-N- 分子式
- C42H88N14O36S3
- 平均分子量
- 1,461.4 g/mol
概要
Dihydrostreptomycin Sulfate is a semi-synthetic aminoglycoside antibiotic with bactericidal properties. Dihydrostreptomycin sulfate inhibits protein synthesis by binding to the 30S ribosomal subunit. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tulemia.
名称と識別子
- 優先名称
- Dihydrostreptomycin Sulfate
- IUPAC
- bis(2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine);sulfuric acid
- 現地名
- 4-O-[2-O-[2-(メチルアミノ)-2-デオキシ-α-L-グルコピラノシル]-5-デオキシ-3-(ヒドロキシメチル)-α-L-リキソフラノシル]-N,N'-ジアミジノ-D-ストレプタミン/硫酸塩,(1:x)
- 英語名
- Dihydrostreptomycin sesquisulfate salt
- 分子式
- C21H43N7O16S
- 分子量
- 681.67
名称と別名
Dihydrostreptomycin sulfate5490-27-7DIHYDROSTREPTOMYCIN SESQUISULFATEDihydrostreptomycin sulfate (USP)Dihydrostreptomycin sequisulphateDTXSID6045824NSC-7567392-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine;sulfuric acidT7D4876IUEDTXCID4025824D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)Pfizer-Strep
名称をさらに表示
4-O-[2-O-[2-(メチルアミノ)-2-デオキシ-α-L-グルコピラノシル]-5-デオキシ-3-(ヒドロキシメチル)-α-L-リキソフラノシル]-N,N'-ジアミジノ-D-ストレプタミン/硫酸塩,(1:x)DIDROMYCINE SULFATEWelcome to consult Zhang JunTDIHYDROSTREPTOMYCIN SESQUISULFATE SAL
物性
構造計算による物性
- 極性表面積
- 928 Ų
- 水素結合供与体数
- 32
- 水素結合受容体数
- 42
- 回転可能結合数
- 18
- 重原子数
- 95
- 形式電荷
- 0
- 複雑度
- 993
実験および物理化学的性質
Animal DrugsActive Ingredients (Dihydrostreptomycin Sulfate) -> FDA Greenbook
物理化学的性質
- 融点
- 200 °C · >200°C (dec.)
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- 2 O: · H2O: 50 mg/mL、透明、微黄色
- 外見
- 結晶性
- 色
- 白い
- 安定性
- 吸湿性
- InChIKey
- GSPKOIJAMLDYCY-XKIHQDMANA-N
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 21.3% (38 of 178) of reports.
Danger
H302 (54.5%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P318, P319, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 178 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory Information
Dihydrostreptomycin sulphate: Does not have an individual approval but may be used under an appropriate group standard
Dihydrostreptomycin sulfate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety Information
IMAP assessments - D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (54.5%)
安全データ
- wgk
- 3
- rtecs
- WK2236000
化学と産業
薬理情報
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
用途と製造
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
General Manufacturing InformationD-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3): INACTIVE
サプライヤー33 社
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
湖北恒硕化工有限公司027-82830253 13995541600 · [email protected]
Protheragen-ING+86-15618352007 · [email protected]
淄博容纳生物科技有限公司+86-86-13583358881 +8618560316533 · [email protected]
上海梅凯科技有限公司021-68689288 15300790979 · [email protected]
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