基本情報
- CAS
85320-68-9- 標準SMILES
COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1- InChIKey
LVEXHFZHOIWIIP-UHFFFAOYSA-N- 分子式
- C18H24N2O5S
- 平均分子量
- 380.5 g/mol
- 単同位体質量
- 380.14059304
概要
Amosulalol is a sulfonamide.
名称と識別子
- 優先名称
- Amosulalol
- IUPAC
- 5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide
- 現地名
- アモスラロール
- 英語名
- Amosulalol
- 分子式
- C18H24N2O5S
- 分子量
- 380.46
名称と別名
Amosulalol85320-68-9AmosulalolumC69JI1BAU8DTXSID908688935-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide5-[1-Hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methylbenzenesulfonamideRefChem:112259DTXCID50816951Amosulalol [INN]5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamideAmosulalol (INN)
名称をさらに表示
rac-5-[(R*)-1-ヒドロキシ-2-[[2-(2-メトキシフェノキシ)エチル]アミノ]エチル]-2-メチルベンゼンスルホンアミドアモスラロールAmosulalol USP/EP/BPAmosulalol, 10 mM in DMSOBenzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-Benzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-, (+-)-
(+-)-5-(1-Hydroxy-2-((2-(o-methoxyphenoxy)ethyl)amino)ethyl)-o-toluenesulfonamideAmosulalolum [Latin]UNII-C69JI1BAU8AMOSULALOL [MI]5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methyl-benzenesulfonamideAMOSULALOL [WHO-DD]SCHEMBL48933CHEMBL152231
データベース識別子
- CAS
85320-68-9- PubChem CID
- 2169
- DTXSID
DTXSID90868893- ChEMBL
CHEMBL152231- ChEBI
CHEBI:135592- UNII
- C69JI1BAU8
- Nikkaji
- J239.723D
物性
構造計算による物性
- XLogP
- 1.2
- 極性表面積
- 119 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 7
- 回転可能結合数
- 9
- 重原子数
- 26
- 形式電荷
- 0
- 複雑度
- 510
物理化学的性質
- 外見
- Solid
- 色
- White to off-white
化学と産業
薬理情報
MeSH Pharmacological Classification
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
応用分野
説明Amosulalol is a potent antihypertensive with combined alpha and beta blocking properties. Indicated for the treatment of essential hypertension, it appears to possess a minimum of side-effects. Its beta-blocking property reduces the tachycardia associated with alpha-blockers, while its alpha-blocking activity reduces the peripheral vasoconstriction associated with beta-blockade.
上流・下流製品情報
上流原料
サプライヤー9 社
LGM Pharma1-(800)-881-8210 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
陕西缔都医药化工有限公司+86-029-81138252 +86-173 9270 1263 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
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