アセマンナン
Acemannan
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基本情報
- CAS
110042-95-0- 標準SMILES
COC1OC(CO)C(OC2OC(CO)C(OC3OC(CO)C(OC4OC(CO)C(OC5OC(CO)C(OC6OC(C(=O)O)C(OC7OC(CO)C(OC8OC(CO)C(OC)C(OC(C)=O)C8O)C(OC(C)=O)C7O)C(OC(C)=O)C6O)C(OC(C)=O)C5O)C(O)C4NC(C)=O)C(OC(C)=O)C3O)C(OC(C)=O)C2O)C(OC(C)=O)C1O- 分子式
- C64H97NO49
- 平均分子量
- 1,664.43 g/mol
名称と識別子
- 優先名称
- Acemannan
- 現地名
- アセマンナン
- 英語名
- Acemannan
- 分子式
- C64H97NO49
- 分子量
- 1664.43
名称と別名
アセマンナンエースマンナンAce-mCarrisynAcemannanAids000120Aids-000120PolymannoacetateAloeverose (15 mg)Aloe vera mucilageAcemannan (Technical Grade)Acemannan polysaccharide from Aloe vera
データベース識別子
- CAS
110042-95-0- PubChem CID
- 21883405
化学と産業
応用分野
説明Acemannan Hydrogel was marketed in the US as a wound healing agent for the care of ulcers, burns and post-surgical incisions. Acemannan is a complex water soluble polymanno- galacto acetate isolated from Aloe vera by alcohol precipitation and purified by filtration to limit the size of the polysaccharide polymers. Pharmacological studies demonstrated immunostimulatory activity through the activation of monocytes and macrophages triggering enhanced secretion of cytokines such as interferon, interleukins, TNF-alpha, GM-CSF and some prostaglandins. It was proposed that the adjuvant activity of this agent could be partly related to its ability to induce phenotypic and functional maturation of immature dendritic cells. In normal healthy males, acemannan administered orally up to 3200 mg/day for 6 days did not show any acute oral toxicity. Acemannan is currently undergoing clinical trials for the treatment of AIDS.
使用Antiviral; immunomodulator.
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