基本情報
- CAS
167621-24-1- 標準SMILES
CCC(=O)Nc1c(C)cc(C(=O)N2CCC(N(C)CCc3ccccc3)CC2)cc1C.Cl- InChIKey
ADNUSXMBYGPKTH-UHFFFAOYSA-N- 分子式
- C26H36ClN3O2
- 平均分子量
- 458 g/mol
- 単同位体質量
- 457.2496051
概要
At low doses, OPC 28326 selectively vasodilates the femoral arterial bed due to its inhibitory action at alpha-2-adrenoceptors while having minimal action on systemic blood pressure, heart rate and coronary, carotid, vertebral, renal, and mesenteric blood flows. It is the only clinical compound with this profile. It is currently being investigated in the treatment of peripheral vascular diseases and Raynaud's syndrome.
名称と識別子
- 優先名称
- Opc 28326
- IUPAC
- N-[2,6-dimethyl-4-[4-[methyl(2-phenylethyl)amino]piperidine-1-carbonyl]phenyl]propanamide;hydrochloride
名称と別名
Opc 28326167621-24-1DTXSID20168338RefChem:856798DTXCID6090829OPC-28326LE5Y6NVZ3SPropanamide, N-(2,6-dimethyl-4-((4-(methyl(2-phenylethyl)amino)-1-piperidinyl)carbonyl)phenyl)-, monohydrochlorideN-[2,6-dimethyl-4-[4-[methyl(2-phenylethyl)amino]piperidine-1-carbonyl]phenyl]propanamide;hydrochlorideUNII-LE5Y6NVZ3SSCHEMBL7469382OPC-28326 ANHYDROUS
名称をさらに表示
N-(2,6-Dimethyl-4-((4-(methyl(2-phenylethyl)amino)-1-piperidinyl)carbonyl)phenyl)propanamide hydrochloride4-(N-METHYL-2-PHENYLETHYLAMINO)-1-(3, 5-DIMETHYL-4-PROPIONYLAMINOBENZOYL)PIPERIDINE HYDROCHLORIDEN-(2,6-Dimethyl-4-{4-[methyl(2-phenylethyl)amino]piperidine-1-carbonyl}phenyl)propanamide--hydrogen chloride (1/1)PROPANAMIDE, N-(2,6-DIMETHYL-4-((4-(METHYL(2-PHENYLETHYL)AMINO)-1-PIPERIDINYL)CARBONYL)PHENYL)-, HYDROCHLORIDE (1:1)
データベース識別子
- CAS
167621-24-1- PubChem CID
- 219019
- DTXSID
DTXSID20168338- UNII
- LE5Y6NVZ3S
物性
構造計算による物性
- 極性表面積
- 52.7 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 3
- 回転可能結合数
- 7
- 重原子数
- 32
- 形式電荷
- 0
- 複雑度
- 569
化学と産業
薬理情報
Pharmacodynamics
At low doses, OPC 28326 selectively vasodilates the femoral arterial bed due to its inhibitory action at alpha-2-adrenoceptors while having minimal action on systemic blood pressure, heart rate and coronary, carotid, vertebral, renal, and mesenteric blood flows.
Mechanism of ActionAt low doses, OPC 28326 selectively vasodilates the femoral arterial bed due to its inhibitory action at alpha-2C-adrenoceptors. Other studies have also reported selectivity for a-2B-adrenoceptors.
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