CAS 141625-93-6 Dronedarone Hydrochloride (HCID 219025)

概要

Dronedarone Hydrochloride is the hydrochloride salt form of dronedarone, an orally bioavailable benzofuran derivative, with anti-arrhythmic activity. Upon oral administration, and although the exact mechanism of action through which dronedarone exerts its anti-arrhythmic effect has not been fully elucidated, it inhibits multiple voltage-gated ion channels, including sodium, potassium, and calcium ion channels, and restores the normal sinus rhythm and reduces heart rate in atrial fibrillation. It also non-competitively antagonizes adrenergic receptors.

名称と識別子

優先名称: Dronedarone Hydrochloride
IUPAC: N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide;hydrochloride
現地名: ドロネダロン塩酸塩
英語名: Dronedarone hydrochloride
分子式: C31H44N2O5S.ClH
分子量: 593.22

名称と別名

Dronedarone hydrochloride141625-93-6Dronedarone HClSR33598BUNII-FA36DV299QFA36DV299QN-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide monohydrochlorideDTXSID30161779DRONEDARONE HYDROCHLORIDE [EP MONOGRAPH]N-(2-Butyl-3-(4-(3-(dibutylamino)proproxy)benzoyl)benzofuran-5-yl) methanesulfonamide-, monohydrochlorideDRONEDARONE HYDROCHLORIDE (MART.)DRONEDARONE HYDROCHLORIDE [MART.]

名称をさらに表示

ドロネダロン塩酸塩N-[2-ブチル-3-[4-[3-(ジブチルアミノ)プロポキシ]ベンゾイル]-5-ベンゾフラニル]メタンスルホンアミド塩酸塩ドロンダロン塩酸塩ドロネダロン塩酸塩Dronedarone hydrochloride, ≥98% (HPLC)MultaqCS-132SR33589SR-33589BCAS:141625-93-6DRONEDARONE HCl CAS:Multaq Hydrochloride.SR33589 Hydrochloride

DRONEDARONE HYDROCHLORIDE (USP-RS)DRONEDARONE HYDROCHLORIDE [USP-RS]Methanesulfonamide, N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-, monohydrochlorideDRONEDARONE HYDROCHLORIDE (EP MONOGRAPH)DRONEDARONE HYDROCHLORIDE (USP MONOGRAPH)DRONEDARONE HYDROCHLORIDE [USP MONOGRAPH]Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-, monohydrochlorideRefChem:55074

データベース識別子

CAS: 141625-93-6
PubChem CID: 219025
DTXSID: DTXSID30161779
ChEMBL: CHEMBL1201729
UNII: FA36DV299Q
EC Number: 630-355-2

物性

構造計算による物性

極性表面積: 97.2 Å²
水素結合供与体数: 2
水素結合受容体数: 7
回転可能結合数: 18
重原子数: 40
形式電荷: 0
複雑度: 800

実験および物理化学的性質

Human Drugs · 2 件

FDA approved drugs -> Active ingredient

物理化学的性質

融点: NA (low-melting)
貯蔵温度: 2 · 2-8°C
溶解性: 15 mg/mL、透明 · DMSO：可溶15mg/mL、透明
外見: 粉
色: ホワイトからオフホワイト
Merck: 14 · 14,3449
安定性: 吸湿性
InChIKey: DWKVCQXJYURSIQ-UHFFFAOYSA-N
SMILES: Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23

化学的性質

化学的特性Pale Yellow Solid

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 8.3% (1 of 12) of reports.

Warning

H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P260, P261, P263, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 12 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Hazard Classes and CategoriesAcute Tox. 4 (33.3%)

毒性情報

Drug Induced Liver Injury · 6 件

Drug Induced Liver Injury Rank (DILIrank 2.0)

Dronedarone hydrochloride

vMost-DILI-concern

7

Warnings & precautions

DOI:10.1016/j.drudis.2016.02.015

安全データ

wgk: 3
ridadr: UN 3077 9 / PGIII
hs_code: 2935904000
ストレージクラス: 11 - Combustible Solids

化学と産業

応用分野 · 2 件

来歴DRONEDARONE HYDROCHLORIDE (brand name: Multaq) is an antiarrhythmic drug developed by Sanofi-Aventis. It was approved by the FDA in July 2009 for the treatment of atrial fibrillation and atrial flutter, reducing the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL). The drug was developed to create a treatment that maintains the therapeutic benefits of amiodarone while reducing associated serious side effects such as pulmonary toxicity and thyroid dysfunction. DRONEDARONE HYDROCHLORIDE is usually administered orally in tablet form. The recommended dose is 400 mg twice daily, one tablet in the morning and one in the evening.

使用Dronedarone Hydrochloride can be used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.