2,5-ジアミノトルエン 硫酸塩

Fires involving this material should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Use water spray, foam, dry powder, carbon dioxide.

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Selected as the 2025 American Contact Dermatitis Society Allergen of the Year. It disproportionately affects hairdressers and frequent users of hair dye.

A 2025 publication notes that toluene-2,5-diamine sulfate is often omitted from standard patch test screening series and thus is possibly underdiagnosed.

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

On the basis of the data presented in this report the CIR Expert Panel concludes that toluene-2,5-diamine and toluene-2,5-diamine sulfate are safe as hair dye ingredients in the present practices of use and concentration as described in this safety assessment, but the availaale data are insufficient to support the safety of toluene-3,4 diamine as a hair dye ingredient

Safe for use in cosmetics, with qualifications

/OTHER TERRESTRIAL SPECIES/ ...The toxicity of 10 benzamines was tested by the well diffusion assay technique against 18 common bacterial species including the nitrogen-fixing bacterium Azotobacter vinelandii. ... 2,5-Diaminotoluene was inhibitory to the growth of P. fluorescens and Streptococcus mitis. The growth of A. vinelandii was inhibited by p-phenylenediamine and 2,5-diaminotoluene in the well diffusion assay. ... The nitrogenase activity of A. vinelandii was inhibited by p-phenylenediamine, 2,5-diaminotoluene, p-nitroaniline, 2-nitro-p-phenylenediamine, 3-nitro-o-phenylenediamine, and 4-nitro-o-phenylenediamine. Because many of these organisms are common soil and aquatic bacteria, the accumulation of these benzamine compounds in the environment may have an adverse impact on soil biochemical activities. /2,5-diaminotoluene/

Redness.

Redness.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of November 6, 2012: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=6369-59-1]

The ability of 2,5-toluenediamine sulfate to induce morphological transformation in Syrian golden hamster embryo cells (Cell Transformation Assay) was evaluated prior to and after Simian adenovirus 7 inoculation. 2,5-Toluenediamine was tested in duplicate, at concentrations of 3.13, 6.25, 12.5, 25 or 50ug/ml prior to virus inoculation, resulting in a range of 100% to 25% relative survival (trial I) and 100% to 47% relative survival (trial II). Assays preformed after virus inoculation at concentrations of 1.00, 1.50, 2.24, 3.34 or 5.00ug/ml, resulting in a range of 100% to 23% relative survival. In a second trial, assays performed after virus inoculation at concentrations of 1.00, 1.78, 3.16, 5.62 or 10.0ug/ml, resulting in a range of 100% to 0% relative survival. At least one of the treatments in all four trials produced greater transformation frequencies (p < 0.01) relative to the negative control. A dose-response relationship was also observed.

The ability 2,5-toluenediamine sulfate to induce 6-thioguanine resistant mutants of Chinese hamster ovary (CHO) cells was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Nonactivated cultures were tested at concentrations up to 50ug/mL, and activated cultures were tested at concentrations up to 750ug/mL. Choice of test concentrations and relative growth after treatment were not reported. 2,5-Toluene diamine sulfate produced mutant frequencies greater than the negative control with and without metabolic activation, but a dose-response was not observed.

The mutagenicity of 2,5-toluenediamine sulfate was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537 and TA1538 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on preliminary toxicity determinations, 2,5-toluenediamine sulfate, was tested at concentrations up to 5000ug/plate using the plate incorporation technique. 2,5-Toluenediamine sulfate produced a positive response in tester strains TA98, TA100, TA1537 and TA1538 with metabolic activation, and a clear dose-response was observed.

The effect of 2,5-toluenediamine sulfate (TDS) on testicular DNA synthesis was evaluated in Charles River mice. Animals were sacrificed and testes removed 3.5 hours following administration of test article at 63 mg/kg by intraperitoneal injection in one test and at 32 mg/kg in a second test. In the first test (63 mg/kg) TDS statistically significantly (t-test, p < 0.01) inhibited testicular DNA synthesis as measured by the amount of tritiated thymidine incorporated into DNA of testes homogenates from treated (1.85 dpm/ug) vs control animals (19.09 dpm/ug). In the second test (32 mg/kg), significant inhibition was not observed (p > 0.10).

/HUMAN EXPOSURE STUDIES/ The degree and pattern of hand eczema in hairdresser trainees and hairdressers was compared in Norway. 75 hairdressers affected by hand eczema and 74 hairdresser trainees with or without hand eczema were examined and patch tested with a hairdressers' series and some additional substances from the standard series. 2.7% of the hairdressers affected by hand eczema were test positive to toluene-2,5-diamine sulfate, compared to 0% of the hairdresser trainees.

/HUMAN EXPOSURE STUDIES/ 103 hairdressers (not dermatitis patients) in the Netherlands (96 females and 8 males) were patch tested with a special series including standard allergens and hairdressers' allergens. 2% were positive to toluene-2,5-diamine sulfate, 6% to p-phenylenediamine and 4% to 2-nitro-4-phenylenediamine.

/HUMAN EXPOSURE STUDIES/ In a multi-center study by the German Contact Dermatitis Group (DKG), 178 dermatitis patients (hairdressers) were patch tested with hairdressers' allergens in 11 centers. 18.0% were test positive to toluene-2,5-diamine, 8.4% to toluene-2,5-diamine sulfate, 18.0% to p-phenylenediamine base, 0.6% to resorcinol, 1.1% to 3-aminophenol, 2.2% to p-aminodiphenylamin hydrochloride, 3.4% to 4-aminophenol and 6.2% to o-nitro-p-phenylendiamine.

/HUMAN EXPOSURE STUDIES/ In a multi-center study by the Italian Contact Dermatitis Research Group (GIRDCA), a total of 302 dermatitis patients (hairdressers) (259 females and 43 males) were patch tested with hairdressers' allergens in 9 Italian centers. 13.2% were positive to toluene-2,5-diamine sulfate, 16.6% to p-phenylenediamine base (in 1989-1990), 7.6% to p-phenylenediamine dihydrochloride (in 1985-1988), 7.9% to o-nitro-p-phenylenediamine, 1.3% to resorcinol and 10.6% to p-aminodiphenylamine.

For more Human Toxicity Excerpts (Complete) data for 2,5-DIAMINOTOLUENE SULFATE (10 total), please visit the HSDB record page.

2,5-Toluenediamine sulfate

TR-126: Bioassay of 2,5-Toluenediamine Sulfate for Possible Carcinogenicity (CASRN 6369-59-1) (1978 )

06/25/78

No Evidence

No Evidence

No Evidence

/LABORATORY ANIMALS: Acute Exposure/ The ocular irritancy potential of toluene-2,5-diamine sulfate was studied using the chorioallantoic membrane of 6 freshly fertilized White Leghorn chicken eggs in a Hen's Egg Test Chorioallantoic Membrane (HET-CAM) test. The test material was undiluted (99.9% pure) and was applied to the chorioallantoic membrane and rinsed off with physiological saline after 30 seconds. Texapon ASV 70 (sodium magnesium laurylmyristyl-6-ethoxysulfate) at a concentration of 5% was used as a reference material, as it is defined as moderately irritating to rabbit eyes in vivo. End points of hemorrhage, coagulation, and blood vessel lysis were semi-quantitatively scored at 30 seconds (for the reference material) or 180 seconds (for the test material) after rinsing. The end points were scored as 0, 0, and 0, respectively, for toluene-2,5-diamine sulfate. In the reference material, the end points were 12, 9, and 0, respectively.

/LABORATORY ANIMALS: Acute Exposure/ A 10% concentration of toluene-2,5-diamine sulfate was administered to CFY strain rats (groups of 5 per sex) by oral intubation at doses of 0, 64, 100, 160, or 250 mg/kg of body weight. Treatment-related effects included lethargy, piloerection, ataxia, and increased salivation. Respiratory rates were increased in the 100-mg/kg dose group and decreased in the dose groups above 100 mg/kg. ...Necropsies were performed on the surviving rats. No abnormalities indicative of residual systemic effects were observed.

/LABORATORY ANIMALS: Acute Exposure/ The aim was to assess the skin sensitizing potency in the guinea pig of ten dye intermediates, including toluene-2,5-diamine sulphate, and to compare the results with results from patch testing hair coloring dermatitis patients in Japan. The study was performed by a non-guideline method. Pre-tests were performed by occluded exposure to determine the irritancy threshold. Topical induction was performed by occluded exposure for 48 hours on the nape, 3 times per week for two weeks. Following a 2 week rest period, challenge was performed by occluded exposure for 48 hours on the flank. Readings were made at 24 and 48 hours after removal of the test material. It was reported that 40% of the animals were positive to toluene-2,5-diamine sulfate at challenge with 1%, and 10% at challenge with 0.10%.

/LABORATORY ANIMALS: Acute Exposure/ The skin sensitizing potential of 2-methyl-1,4-benzenediamine sulfate was investigated by measuring the cell proliferation in the draining lymph nodes after topical application on the ear. 25 uL containing 0 (vehicle only), 0.5, 1.5 and 5.0% of the test substance in DMSO were applied to the surface of the ear to each of five mice per group for three consecutive days. p-Phenylenediamine (PPD) at 1% in DMSO was used as the positive control in parallel under identical test conditions. On day 5, the mice received an intravenous injection of 250 uL phosphate buffered saline containing 20 uCi of (3)H-methyl thymidine. Approximately five hours later, the mice were sacrificed by CO2-inhalation and the draining auricular lymph nodes were removed. After preparing a single cell suspension for each mouse, cells were precipitated by TCA and the radioactivity was determined (incorporation of (3)H-methyl thymidine in the pellets) by means of liquid scintillation counting as disintegration per minute (dpm). The mean dpm per treated group was determined and the stimulation index (test item compared to the concurrent vehicle control) was calculated. Mean stimulation indices (SI) of 4.9, 4.2, and 3.7 were obtained for the test concentrations of 0.5, 1.5 and 5%, respectively. No EC3 value was calculated, since all stimulation indices were above 3. The positive control (PPD 1% in DMSO) caused a stimulation index of 10.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,4-Benzenediamine, 2-methyl-, sulfate is included on this list. Effective date: 4/29/83; Sunset date: 4/29/93.

CIR ingredient: Toluene-2,5-Diamine Sulfate

Used in hair dyes, bleach-toner formulas, and brown fur dyes; [HSDB]

Fur Dressing and Dyeing [Category: Industry]

Used in hair dyes; [EC - SCCS]

Dressing Hair [Category: Other]

Used as ingredients in the formulation of permanent hair dyes, colors, and tints

The Scientific Committee on Consumer Products also reported that toluene-2,5-diamine sulfate (concentration of solution not provided) had greater than 98% wt/wt HPLC quantitative purity, greater than 99% HPLC qualitative (254 nm) purity, a solvent content less than 1%, and the potential impurity o-toluidine less than 50 ppm.

(1976) 1.30X10+6 G (PRINCPL CUSTMS DISTS)

(1978) 5.87X10+6 G (PRINCPL CUSTMS DISTS)

1,4-Benzenediamine, 2-methyl-, sulfate (1:1): ACTIVE

1,4-Benzenediamine, 2-methyl-, sulfate (1:?): ACTIVE

According to a survey of current use concentrations conducted by the Cosmetic, Toiletry, and Fragrance Association (CTFA), ... toluene-2,5-diamine sulfate is used at concentrations of 0.1% to 4.0%in hair dyes and colors and at 3% in hair bleaches.

2,5-Diaminotoluene sulfate was first produced commercially in the USA in 1927.