ケイ素酸ソダ

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

In case of fire in the surroundings, use appropriate extinguishing media.

Fresh air, rest.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: self-contained breathing apparatus.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Dermatotoxin - Skin burns.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

The Expert Panel for Cosmetic Ingredient Safety concluded that the following 24 silicate ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating, with the exception that the available data are insufficient to make a determination of safety for the use of naturally-sourced (i.e., mined) silicate ingredients in products that may be incidentally inhaled: Sodium Metasilicate.

Safe for use in cosmetics, with qualifications

The Expert Panel for Cosmetic Ingredient Safety concluded that the following 24 silicate ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating, with the exception that the available data are insufficient to make a determination of safety for the use of naturally-sourced (i.e., mined) silicate ingredients in products that may be incidentally inhaled: Sodium Silicate.

Safe for use in cosmetics, with qualifications

Cough. Sore throat.

Redness. Pain.

Redness. Pain.

Diarrhoea. Nausea. Vomiting.

A 57 yr old man had had recurrent ulcerative lesions on his left hand for 2 yr. The ulcers were associated with chronic eczematous changes resulting from primary irritant contact dermatitis to sodium silicate, as indicated by positive patch tests. He used sodium silicate in a dyeing process in his work. He also had contact urticaria. An immediate wheal and flare reaction was found 15 min after application of sodium silicate to a scratch test site. This response was not seen in healthy control subjects.

MORE...CAUSTIC THAN SODIUM SILICATE. ... /IT IS/ THE MOST ALKALINE & CORROSIVE SUBSTANCE IN.../PHOSPHATE-FREE & LOW-PHOSPHATE LAUNDRY DETERGENTS & DISHWASHER PRODUCTS/.

IRRITATING & CAUSTIC TO SKIN, MUCOUS MEMBRANES. IF SWALLOWED CAUSES VOMITING & DIARRHEA.

Upper airway irritation, fever/hyperthermia (metal fume fever), leukocytosis (metal fume fever).

ACCIDENTAL SPLASHES IN EYE FOLLOWED PROMPTLY BY WASHING WITH WATER HAVE BEEN OBSERVED TO DAMAGE THE CORNEAL EPITHELIUM.

ORAL PREPN OF SODIUM METASILICATE WERE FED TO YOUNG ADULT BEAGLE DOGS AND YOUNG RATS OF BOTH SEXES FOR 4 WK. POLYDIPSIA, POLYURIA & SOFT STOOLS RESULTED IN SOME ANIMALS. GROSS & MICROSCOPIC RENAL LESIONS OBSERVED IN DOGS BUT NOT IN RATS.

... /In/ studies of detergent emesis in 11 dogs by gastric intubation ... 8 mg/kg as a 10.5% aqueous solution of a sodium silicate (SiO2:Na2O= 3.2:1) produced emesis in 6 minutes which continued for up to 33 minutes.

Sodium metasilicate is used with sodium carbonate in heavy duty alkaline laundry detergents. In rabbits this type of detergent causes damage to the cornea, with opacification, proportional to the alkalinity of the preparation. Irrigation of the eye with water must be done within 60 seconds to reduce the severity of injury.

The ip injection in rats of the nonahydrate as a neutral solution in amounts of 300 mg on day 1 and 200 mg on days 2 and 3 produced lesions in the spleen and lymph nodes and caused mitotic changes in the nuclie of cells resembling those from ionizing radiation or hypoxia. /Nonahydrate/

For more Non-Human Toxicity Excerpts (Complete) data for SODIUM METASILICATE (6 total), please visit the HSDB record page.

Mussels are controlled on water inlets, underwater substructures, ditches, etc by asphyxiation subsequent to coating with a hydrogel made of sodium silicate. Furthermore, algae and aquatic plants can be eliminated by addition of herbicides to the hydrogel. ... Water glass, diluted 1:2, with pH adjusted to 7.4, controlled mussels in a water inlet.

LD50 Rat oral 1280 mg/kg

LD50 Mouse oral 2400 mg/kg

LD50 Rat oral 1.1 - 1.6 g/kg

LD50 Mouse oral 1,100 mg/kg

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Sodium metasilicate is found on List D. Case No: 4081; Pesticide type: insecticide, fungicide, antimicrobial; Case Status: RED Approved 09/91; OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Sodium metasilicate; AI Status: OPP has completed a Reregistration Eligibility Decision (RED) document for the case/AI.

As a general rule, pesticide chemicals other than ..., sodium metasilicate (not to exceed 4% by weight in aqueous solution)... are not for the purposes of section 408(a) of the Act generally recognized as safe.

Residues of sodium metasilicate are exempted from the requirement of a tolerance when used as a surfacant, emulsifier, wetting agent, suspending agent, dispersing agent, or buffer in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Residues of sodium silicate are exempted from the requirement of a tolerance when used as a surfactant, emulsifier, wetting agent, stabilizer, or inhibitor in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.