D-グルタミン酸
D-Glutamic Acid
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基本情報
- CAS
6893-26-1- 標準SMILES
N[C@H](CCC(=O)O)C(=O)O- InChIKey
WHUUTDBJXJRKMK-GSVOUGTGSA-N- 分子式
- C5H9NO4
- 平均分子量
- 147.13 g/mol
- 単同位体質量
- 147.05315777
概要
D-glutamic acid is an optically active form of glutamic acid having D-configuration. It has a role as a mouse metabolite and an Escherichia coli metabolite. It is a D-alpha-amino acid and a glutamic acid. It is a conjugate acid of a D-glutamate(1-). It is an enantiomer of a L-glutamic acid.
名称と識別子
- 優先名称
- D-Glutamic Acid
- IUPAC
- (2R)-2-aminopentanedioic acid
- 現地名
- D-グルタミン酸
- 英語名
- D(-)-Glutamic acid
- 分子式
- C5H9NO4
- 分子量
- 147.13
名称と別名
D-glutamic acid6893-26-1(2R)-2-aminopentanedioic acidD-glutamateD-GluD-Glutaminic acidD-2-Aminoglutaric acid(-)-Glutamic acidDTXSID1048675glutamic acid d-Q479989WEADTXCID1028601
名称をさらに表示
D-グルタミン酸(-)-D-グルタミン酸(R)-2-アミノペンタン二酸(-)-グルタミン酸(R)-2-アミノグルタル酸(2R)-2-アミノグルタル酸Dグルタミン酸D‐グルタミン酸D-GLUCURONOLACTONEd-glutamic(R)-GLUTAMIC ACID(R)-2-Aminoglutaric acid, (R)-2-Aminopentanedioic acid, D-Glu, R-(-)-1-Aminopropane-1,3-dicarboxylic acidNSC 77686
CHEBI:15966NSC-77686(2R)-2-azaniumyl-5-hydroxy-5-oxopentanoateD GlutamateRefChem:583854230-000-8H-D-Glu-OH(R)-2-aminopentanedioic acid
データベース識別子
- CAS
6893-26-1- PubChem CID
- 23327
- DTXSID
DTXSID1048675- ChEMBL
CHEMBL76232- ChEBI
CHEBI:15966- UNII
- Q479989WEA
- EC Number
- 230-000-8
- Nikkaji
- J9.214B
物性
構造計算による物性補完中
- XLogP
- -3.7
- 極性表面積
- 101 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 5
- 回転可能結合数
- 4
- 重原子数
- 10
- 形式電荷
- 0
- 複雑度
- 145
実験および物理化学的性質
Chemical ClassesBiological Agents -> Amino Acids and Derivatives
DrugsPharmaceuticals -> Listed in ZINC15
Solubility8.88 mg/mL at 25 °C
Melting Point201 °C
Physical Description
Shinny solid; [Merck Index] White crystalline powder; [Alfa Aesar MSDS]
Solid
物理化学的性質
- 融点
- 200 · 200-202 °C (subl.)(lit.)
- 比旋光度
- -31.3 · -31.3 º (c=10, 2 N HCl)
- 沸点
- 267.21 °C · 267.21°C (rough estimate)
- 比重(密度)
- 1.538 · 1.5380
- 屈折率
- 1.421 · 1.4210 (estimate)
- 貯蔵温度
- Keep in dark place,Sealed in dry,Room Temperature
- 溶解性
- 水（少々）
- 酸解離定数(Pka)
- 1 · pK1:2.162(＋1);pK2:4.272(0);pK3:9.358(－1) (25°C)
- 外見
- 粉
- 色
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 83.3% (5 of 6) of all reports.
Warning
H315 (16.7%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 6 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory InformationD-Glutamic acid: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryMay cause irritation; [Alfa Aesar MSDS]
Hazard Classes and CategoriesSkin Irrit. 2 (16.7%)
安全データ
- F
- 10
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29224200
- risk_code
- 36/37/38
- 化審法
- (9)-1573 届出不要化学物質
- hazard_code
- Xi
- safety_code
- 24/25-36-26
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
Tissue LocationsEpidermis
Cellular LocationsCytoplasm
用途と製造
UsesGlutamic acid is a non-essential amino acid and excitatory neurotransmitter; Used as a nutritional supplement; [Merck Index]
General Manufacturing InformationD-Glutamic acid: ACTIVE
応用分野
用途シグナル伝達研究用。
使用D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism.
一般的な説明D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.
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