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基本情報
- CAS
100324-80-9- 標準SMILES
C[C@H](O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O- InChIKey
NSMXQKNUPPXBRG-VIFPVBQESA-N- 分子式
- C13H20N4O3
- 平均分子量
- 280.32 g/mol
名称と識別子
- 優先名称
- (S)-Lisofylline
- 英語名
- (S)-Lisofylline
- 分子式
- C13H20N4O3
- 分子量
- 280.32
名称と別名
(S)-Lisofylline(S)-Lisophylline(S)-Lisofylline Exclusive(S)-Lisofylline, 10 mM in DMSO(S)Lisofylline,(S) Lisofylline1-[(5S)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione1H-Purine-2,6-dione, 3,7-dihydro-1-[(5S)-5-hydroxyhexyl]-3,7-dimethyl-
データベース識別子
- CAS
100324-80-9- PubChem CID
- 23519621
- ChEMBL
CHEMBL4300766- ChEBI
CHEBI:143564- UNII
- N939YFB9KP
- Nikkaji
- J784.163I
物性
物理化学的性質
- 貯蔵温度
- -20 °C · Store at -20°C
- 溶解性
- 15 mg/ml · ≤15mg/ml in ethanol;3mg/ml in DMSO;12mg/ml in dimethyl formamide
- 外見
- crystalline solid
- 色
- Off-white to light yellow
化学と産業
応用分野
説明LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer. When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation. Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.
使用LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer. When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation. Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.[Cayman Chemical]
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