Monosodium methanearsonate

(DSMA) 1.0 at 68.0 °F (MSMA solutions) 1.4-1.6 at 20 °C (liquid) (USCG, 1999)

1.535 /51% w/v aqueous technical/

greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)

16 g/100 ml in methanol @ 25 °C; 0.005 g/100 ml in hexane @ 25 °C

Insoluble in most organic solvents

In water, 5.8X10+5 mg/l @ 20 °C.

When heated to decomposition it emits toxic fumes of /arsenic and sodium oxide/.

Decomposed by strong oxidizing and reducing agents.

235 to 241 °F (NTP, 1992)

130-140 °C

Mp: 113-116 °C /Sodium methanearsonate sesquihydrate/

Mp: 132-139 °C /Sodium methanearsonate hexahydrate/

0.00000008 [mmHg]

1X10-5 Pa @ 25 °C (7.8X10-8 mm Hg)

Methanearsonic acid, [sodium salt] appears as odorless colorless solid. Solution may be red or green. Solid may float or sink in water; solid and solution mix with water. (USCG, 1999)

White solid; [Hawley] Colorless odorless solid; [CAMEO]

Danger

H301 (90.7%): Toxic if swallowed [Danger Acute toxicity, oral]；H331 (90.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]；H400 (90.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (90.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 43 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Monosodium acid methanearsonate (MMA) is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)

2002/2076

Restricted substance: Sodium methylarsonate；EC: 218-495-9；Restriction condition document: PDF link

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Subacute poisoning by arsenicals causes salty taste, burning in throat and stomach, and intestinal pain. Acute toxicity indicated by headache, vomiting, stupor, convulsions, paralysis. About 1 ounce to 1 pound must be taken to cause these symptoms. (USCG, 1999)

A skin and eye irritant; [HSDB] Most excreted unchanged; [Rosenstock, p. 947] For MSMA and DSMA, developmental studies of rats and rabbits along with a two-generation reproductive study show no indication of increased susceptibility; No evidence of carcinogenicity; Target organs are large intestines and kidneys; [Reference #1]

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Monosodium methanearsonate is found on List B. Case No: 2395; Pesticide type: insecticide, herbicide, rodenticide; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Monosodium methanearsonate; Data Call-in (DCI) Date(s): 06/14/91, 03/03/95, 10/13/95; AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.

Tolerances are established for residues of the herbicide methanearsonic acid (calculated as As2O3) from application of the disodium and monosodium salts of methanearsonic acid in or on raw agricultural commodities as follows: citrus fruit; cottonseed; and cottonseed hulls.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.；OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.；STORAGE PRECAUTIONS: You should store this material in a refrigerator away from oxidizing and reducing agents. (NTP, 1992)

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:；IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.；SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.；FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)

Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)

Tolerances are established for residues of the herbicide methanearsonic acid (calculated as As2O3) from application of the disodium and monosodium salts of methanearsonic acid in or on raw agricultural commodities as follows: citrus fruit, 0.35 ppm; cottonseed, 0.7 ppm; and cottonseed hulls, 0.9 ppm.

Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue; 2 ppm in uncooked edible by-products; & 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney; 0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/

Protective clothing to prevent contact with skin; chemical goggles. (USCG, 1999)

Protective gloves rubber or neoprene, goggles, or face shield for eye protection, rubber apron.

Long pants, long-sleeved shirt, impermeable gloves, boots for handling or applying. Mixer-loaders should wear an apron and full-face shield for handling, mixing concentrate. Flagmen should be fully protected during spray operations or use mechanical flagmen. Pilots and ground spray rig applicators should wear a mask or approved respirator.

... The following countries had adopted the ... TLV of 0.5 mg/cu m: Austria, Belgium, Finland, Japan, and Holland. Czechoslavakia, East Germany, Hungary and Poland ... USSR ... 0.3 mg/cu m; Romania and Switzerland, 0.2 mg/cu m; Sweden 0.05 mg/cu m; and Italy 0.25 mg/cu m. /Arsenic and sol cmpd/

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)

LC50 GAMMARUS FASCIATUS GREATER THAN 100 MG/L/96 HR @ 15 °C, MATURE. STATIC BIOASSAY WITHOUT AERATION, PH 7.2-7.5, WATER HARDNESS 40-50 MG/L AS CALCIUM CARBONATE AND ALKALINITY OF 30-35 MG/L. /LIQUID FORMULATION, 34.8%/

LC50 SALMO CLARKI (CUTTHROAT TROUT) GREATER THAN 100 MG/L/96 HR @ 10 °C, WT 0.6 G STATIC BIOASSAY WITHOUT AERATION, PH 7.2-7.5, WATER HARDNESS 40-50 MG/L ASCALCIUM CARBONATE AND ALKALINITY OF 30-35 MG/L. /LIQUID FORMULATION, 34.8%/

LC50 CARASSIUS AURATUS (GOLDFISH) 31.1 MG/L/96 HR @ 18 °C (95% CONFIDENCE LIMIT 24.4-38.8 MG/L), WT 0.9 G STATIC BIOASSAY WITHOUT AERATION, PH 7.2-7.5, WATER HARDNESS 40-50 MG/L AS CALCIUM CARBONATE AND ALKALINITY OF 30-35 MG/L. /LIQUID FORMULATION, 34.8%/

LC50 PIMEPHALES PROMELAS (FATHEAD MINNOW) 13.3 MG/L/96 HR @ 18 °C (95% CONFIDENCE LIMIT 5.1-35.8 MG/L), WT 0.9 G STATIC BIOASSAY WITHOUT AERATION, PH 7.2-7.5, WATER HARDNESS 40-50 MG/L AS CALCIUM CARBONATE AND ALKALINITY OF 30-35 MG/L. /LIQUID FORMULATION, 34.8%/

For more Ecotoxicity Values (Complete) data for SODIUM METHANEARSONATE (8 total), please visit the HSDB record page.

Oral (L2) ; inhalation (L2); dermal (L2)

Oral (L2) ; inhalation (L2); dermal (L2)

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).

Organoarsenicals, such as ... methanearsonic acid, monosodium ... salt ... are adsorbed by clay soils. After rapid initial adsorption, changes occur which result in the redistribution of dimethylarsinic acid into a less sol form assoc with aluminum in the soil. Downward leaching of the methanearsonic acid salts has also been reported. The ... salts are fixed by iron and aluminum in the soil, although not as strongly as inorg arsenate.

COMPOUNDS INCLUDED METHANEARSONIC ACID & ITS SODIUM SALTS; 9/34 CASES SHOWED SYSTEMIC SYMPTOMS & REMAINDER HAD EYE & SKIN IRRITATION.

ORGANIC ARSENICALS INCLUDE DISODIUM METHYLARSONATE ... AND AMINE METHYLARSONATE.TOXICITY OF THESE CMPD TO HUMANS IS CONSIDERABLY LESS THAN ... INORGANIC ARSENICALS; HOWEVER THEY ARE HARMFUL IF INHALED, SWALLOWED, OR IF THEY COME IN CONTACT WITH EYES OR SKIN. /DISODIUM METHYLARSONATE/

... DEGRADATION OF MSMA ... /IN/ SOILS. ... SOIL MICROORGANISMS APPEARED TO PLAYSOME ROLE IN DECOMP PROCESS. A FUNGUS, SEVERAL ACTINOMYCETES, & SEVERAL BACTERIA WERE ISOLATED ... THE ORGANISMS DEGRADED 3, 13 OR 9, & 20% OF MSMA IN 11 DAYS, RESPECTIVELY. ... IN THE ABSENCE OF AN ENERGY SOURCE, MICROBIAL METAB ... WAS NONEXISTENT. THE PRODUCTS OF METAB WERE CO2 & ARSENATE. NO ARSENITE COULD BE DETECTED.

3, not classifiable as to its carcinogenicity to humans. (L135)

3, not classifiable as to its carcinogenicity to humans. (L135)

... GAVE MONOSODIUM METHANEARSONATE TO CATTLE THROUGH RENAL TUBULES @ DOSE OF 10 MG/KG DAILY. FOUR OF 5 ... TREATED DIED AFTER 8-10 DAYS OF TREATMENT. CAUSE OF DEATH WAS APPARENT KIDNEY FAILURE. HIGH LEVELS OF ARSENIC WERE FOUND IN KIDNEY & LIVER. ... 100 & 1000 PPM BY WT OF ... MONOSODIUM METHANEARSONATE /IN 60% SUCROSE SYRUP/ WERE EXTREMELY TOXIC TO NEWLY EMERGED WORKER BEES ... NO DIFFERENCES IN TOXICITY WERE OBSERVED BETWEEN PURIFIED & COMMERCIALLY FORMULATED HERBICIDES.

... EXAMINED EFFECTS OF MONOSODIUM METHANEARSONATE & CACODYLIC ACID ON INSECT MORTALITY IN TREATED PONDEROSA PINES ... DIFFERENCES OF INSECT SURVIVAL BETWEEN CMPD WERE NOTED.

COTTON ... INJURED BY MONOSODIUM METHANEARSONATE APPLICATION 3.36 KG/HA ... @ 13 OR 20 °C. NO INJURY @ 31 °C.

Long term feeding of 50 mg/kg of diet of methanearsonic acid, monosodium salt (1.5 mg/kg bw/day as arsenic) to rabbits produced toxic hepatitis.

For more Non-Human Toxicity Excerpts (Complete) data for SODIUM METHANEARSONATE (11 total), please visit the HSDB record page.

Monosodium acid methanearsonate (MMA) is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)

2002/2076

Restricted substance: Sodium methylarsonate；EC: 218-495-9；Restriction condition document: PDF link

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Monosodium methanearsonate is found on List B. Case No: 2395; Pesticide type: insecticide, herbicide, rodenticide; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Monosodium methanearsonate; Data Call-in (DCI) Date(s): 06/14/91, 03/03/95, 10/13/95; AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.

Tolerances are established for residues of the herbicide methanearsonic acid (calculated as As2O3) from application of the disodium and monosodium salts of methanearsonic acid in or on raw agricultural commodities as follows: citrus fruit; cottonseed; and cottonseed hulls.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Sodium methanearsonate is included on this list.

(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/

For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/

D004; A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.

(AZ) ARIZONA 10 ug/L /Arsenic/

(CT) CONNECTICUT 10 ug/l /Arsenic/

ARSONIC ACID HERBICIDES ARE NOT GROWTH REGULATORS IN SENSE OF PLANT HORMONES. THEY ... ACT THROUGH ENZYME SYSTEMS TO INHIBIT GROWTH. THEY KILL ... SLOWLY; FIRST SYMPTOMS ARE ... CHLOROSIS, CESSATION OF GROWTH, & GRADUAL YELLOWING, THEN BROWNING FOLLOWED BY DEHYDRATION & DEATH. /ORGANOARSENICAL HERBICIDES/

... DEGRADATION OF MONOSODIUM METHANEARSONATE IN BEANS ... 3-5% OF ARSENIC RECOVERED IN EXTRACT REMAINED BOUND TO INSOL RESIDUE. ... OF REMAINING RESIDUE ... ABOUT 60% WAS ASSOCIATED WITH A NINHYDRIN-POS SUBSTANCE (RF= 0.69) WHILE 40% WAS UNCOMPLEXED MSMA (RF= 0.35). ... MONOSODIUM METHANEARSONATE ON COTTON. LITTLE OR NO METAB...DURING 72 HR PLANT EXPOSURE. ... COTTON APPARENTLY FORMS NO COMPLEX, @ LEAST WITHIN 72 HR AFTER TREATMENT. /HISTIDINE COMPLEX PROPOSED, BUT NOT PROVEN, IN OTHER PLANTS/

RESISTANCE TO ENTRY OF PINUS PONDEROSA WAS SUBSTANTIALLY MORE PROLONGED FOR MONOSODIUM METHANEARSONATE THAN FOR CACODYLIC ACID WHICH MAY BE RESULT OF ADDED METABOLIC STEP NECESSARY TO CONVERT MONOSODIUM METHANEARSONATE TO CACODYLIC ACID. ... NO PROOF OF METHYLATION ... OFFERED.

VOLUNTEERS INGESTED A SINGLE ORAL DOSE OF 500 MG ARSENIC AS DISODIUM METHANEARSONATE. AFTER 4 DAYS, 78% OF INGESTED ARSENIC WAS EXCRETED IN URINE. METHANEARSONATE IS 13% METHYLATED INTO DIMETHYLARSINATE. /METHANEARSONIC ACID, DISODIUM SALT/

REACTION OF ... DSMA ... EXAMINED IN ... PLANTS ... SINGLE RADIOACTIVE CMPD ... FOUND /IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS LEGUMINOSAE)/ IN HOT 80% ETHANOL EXTRACT. CHEM ANALYSIS REVEALED THAT C-AS BOND REMAINED INTACT. /METHANEARSONIC ACID, DISODIUM SALT/

For more Metabolism/Metabolites (Complete) data for SODIUM METHANEARSONATE (7 total), please visit the HSDB record page.

Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20)

MSMA ... TRANSLOCATED MORE RAPIDLY THAN CACODYLIC ACID TO ROOT SYSTEM & PROBABLY ... SHOOT TIP, YET IT WAS NOT MORE PHYTOTOXIC. RADIOACTIVE MSMA WAS FOUND ABOVE, BELOW & IN NUTRIENT SOLN WHEN BLACK VALENTINE BEANS WERE TREATED WITH (14)C MSMA. ... NUTSEDGE TUBERS ACCUM ARSENIC & SMALLER TUBERS CONTAINED HIGHEST CONCN.

/IN COTTON/ ... (14)C MSMA TRANSLOCATED OUT OF COTYLEDONS FASTER WHEN TREATED @ 20 °C THAN @ 29 °C. MAX ABSORPTION ... OCCURRED @ 29 °C.

... 10 MG/KG/DAY ... PROVED FATAL TO CATTLE IN 10 DAYS; ARSENIC CONTENT OF KIDNEY & LIVER BEING IN RANGE 27-64 PPM.

No significant arsenic residues are found in cottonseed when the sodium & disodium salts of methanearsonic acid are applied after the cotton has reached a height of 7.6 cm and before early bloom.

For more Absorption, Distribution and Excretion (Complete) data for SODIUM METHANEARSONATE (7 total), please visit the HSDB record page.

Used as post-emergence herbicide for turf, cotton, and non-cropland; [HSDB]

Farming (Pesticides) [Category: Industry]

For Sodium methanearsonate (USEPA/OPP Pesticide Code: 013803) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Post-emergence herbicide for grassy weeds.

ONE OF THE FIRST MAJOR USES WAS AS A SELECTIVE HERBICIDE FOR POSTEMERGENCE CONTROL OF CRABGRASS, DALLISGRASS, & OTHER WEEDY GRASSES IN TURF. CURRENTLY IT IS USED...AS SELECTIVE POSTEMERGENT HERBICIDE IN COTTON & NONCROP AREAS FOR CONTROL OF JOHNSONGRASS, NUTSEDGE, WATERGRASS, SANDBUR, FOXTAIL, COCKLEBUR, PIGWEED, & OTHER WEEDS. IT IS WIDELY USED...FOR CONTROLLING WEEDS & GRASSES IN NONCROP AREAS. NOT FOR USE ON ST AUGUSTINE OR CENTIPEDEGRASS WHERE ITS USE AS TURF IS DESIRABLE. ALSO MIXED WITH 2,4-D/2,4,5-T BRUSHKILLERS ON NONCROPPED AREAS TO INCREASE CONIFER & OTHER BRUSH SPECIES KILL OR DIEBACK. /MONO AND SODIUM SALTS/

Methylarsonic acid, disodium salt is used as an herbicide and pesticide. (L389)

MSMA is produced by the reaction of diarsenic trioxide with methyl chloride and aq sodium hydroxide or by the methylation of sodium arsenite by dimethyl sulfate

MSMA ... formed from DSMA at pH 6-7.

Methyl chloride + arsenic trioxide + sulfuric acid + sodium hydroxide (reaction/neutralization)

USEPA/OPP Pesticide Code 013803; Trade Names: Weed-broom (Use 3 code Nos. 012301,013803 & 030001) mixt, (DSMA, Bromacil & 2,4-D); Ansar 529; Ansar 170; Target MSMA; Phyban H.C.; Deconate; Mesamate; Bueno; Monate Merge 823; Dal-e-rad; Weed-s-rad; Arsanote liquid; Silvisar 550.

Methylarsonic acid, monosodium salt is avail for farm applications as a tech grade in combination with a surfactant, or in combination with sodium cacodylate, dimethylarsinic acid and a surfactant.

MSMA CONTENT, IN LB/GAL: WEED-HOE 120, 6.67; ANSAR 170, 6.67; ANSAR 170 HC, 8.0; WEED-HOE-2X, 8.0; ANSAR 529 (SURFACTANT), 4.0; WEED-E-RAD +W, 4.02 (SURFACTANT); DAL-E-RAD 70 +W, 4.02 (SURFACTANT); WEED-HOE 100 +W, 5.56 (SURFACTANT); ANSAR 529 HC, 6.0 (SURFACTANT); MONEX 3, 6.0; PHYBAN HC, 6.0; BROADSIDE, 3.0; CHEX-MATE, 3.00 (SURFACTANT). /FROM TABLE/

Liq (8 lb/gal) ... Silvisar 550 (tree killer for forestry use). Target MSMA 8 (8lb/gal); Target MSMA 6.6 (6.6 lb/gal); Target MSMA 6 (6 lb/gal) + surfactant: Target MSMA 4 (4 lb/gal) + surfactant ... .

For more Formulations/Preparations (Complete) data for SODIUM METHANEARSONATE (10 total), please visit the HSDB record page.

May be formed by decomp of DSMA /disodium methanearsonate/ at pH 6-7.

... MSMA /HAS BEEN USED/ IN CONJUNCTION WITH TRIFLURALIN TO CONTROL JOHNSONGRASS ... PREPLANT APPLICATION OF TRIFLURALIN REDUCED NUMBER OF MSMA APPLICATIONS NEEDED FOR COMPLETE WEED CONTROL BEFORE COTTON BLOOMED.

/IN MSMA TREATMENT/ ... ATRAZINE ... FACILITATES UPTAKE OF ARSENIC BY /GRAPE/ PLANT.

Incompatabilities: water with high calcium, magnesium, and iron may cause precipitate; these cations form insoluble methane arsonate salts.

For more General Manufacturing Information (Complete) data for SODIUM METHANEARSONATE (7 total), please visit the HSDB record page.