シクラミン酸ナトリウム
Sodium Cyclamate
基本情報
- CAS
139-05-9- 標準SMILES
O=S(=O)([O-])NC1CCCCC1.[Na+]- InChIKey
UDIPTWFVPPPURJ-UHFFFAOYSA-M- 分子式
- C6H11NHSO3.Na
- 平均分子量
- 201.22 g/mol
- 単同位体質量
- 201.0435587
概要
Sodium cyclamate appears as odorless or almost odorless white crystals or crystalline powder. Intensely sweet taste, even in dilute solution. pH (10% solution in water): 5.5-7.5. Used as a non-nutritive sweetener.
名称と識別子
- 優先名称
- Sodium Cyclamate
- IUPAC
- sodium N-cyclohexylsulfamate
- 現地名
- シクラミン酸ナトリウム
- 英語名
- Sodium N-cyclohexylsulfamate
- 分子式
- C6H14NNaO3S
- 分子量
- 203.23
名称と別名
SODIUM CYCLAMATE139-05-9Sucaryl sodiumCyclamate sodiumCyclamic acid sodium saltCyclamate de sodiumCiclamato sodicoAssurgrin vollsussSulfamic acid, cyclohexyl-, monosodium saltSuessetteSuestaminAsugryn
名称をさらに表示
N-シクロヘキシルスルファミン酸 ナトリウムN-シクロヘキシルスルファミン酸ナトリウムシクロシクラム酸ナトリウムN-シクロヘキシルアミド硫酸ナトリウムシクロヘキシルスルファミン酸ナトリウムシクラミン酸ナトリウムチクロサイクラミン酸ナトリウムナトリウム＝シクロヘキシルスルファミダトシクラメートN-シクロヘキサンスルファミン酸ナトリウムサイクラミン酸ナトリウム標準品シクロヘキシルアミド硫酸ナトリウムナトリウムシクラメートナトリウムシクラメート, 98%ナトリウム N-シクロヘキシルスルファマートCYCLAMATEN-CYCLOHEXYLSULFAMIC ACID SODIUM SALTsucrum7cyclamic
IbiosucSugarinSugaronNatrii cyclamasSodium sucarylSodium cyclohexanesulfamateDulzor-EtasHachi-Sugar
データベース識別子
- CAS
139-05-9- PubChem CID
- 23665706
- DTXSID
DTXSID6020355- ChEMBL
CHEMBL273977- ChEBI
CHEBI:82431- UNII
- 1I6F42RME1
- EC Number
- 205-348-9
- Nikkaji
- J813C
物性
構造計算による物性
- 極性表面積
- 77.6 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 4
- 回転可能結合数
- 2
- 重原子数
- 12
- 形式電荷
- 0
- 複雑度
- 205
実験および物理化学的性質
Chemical ClassesOther Uses -> Food Additives
CosmeticsMasking
Food AdditivesNON-NUTRITIVE SWEETENER -> FDA Substance added to food
Solubilitygreater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
Melting Point509 °F (decomposes) (NTP, 1992)
Physical Description
Sodium cyclamate appears as odorless or almost odorless white crystals or crystalline powder. Intensely sweet taste, even in dilute solution. pH (10% solution in water): 5.5-7.5. Used as a non-nutritive sweetener.
White solid; [Hawley] White powder; [MSDSonline]
物理化学的性質
- 融点
- 300 °C · >300 °C (lit.)
- 比重(密度)
- 1.58 · 1.58[at 20℃]
- 蒸気圧
- 0.002 Pa · 0.002Pa at 150℃
- 貯蔵温度
- room temp
- 溶解性
- 200 g/リットル · 200g/リットル
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 44.7% (42 of 94) of reports.
Warning
H302 (54.3%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 94 reports by companies from 7 notifications to the ECHA C&L Inventory.
危険有害性情報
Regulatory Information
Chemical: Sulfamic acid, cyclohexyl-, monosodium salt
REACH registered substance: Sodium cyclamate (EC: 205-348-9)
Sulfamic acid, cyclohexyl-, monosodium salt: Does not have an individual approval but may be used under an appropriate group standard
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards
SYMPTOMS: Symptoms of exposure to this compound include irritation of the skin, eyes, mucous membranes and upper respiratory tract. Other symptoms include softness of the stools, diarrhea, photosensitization and chromosomal changes. Exposure to pregnant women has resulted in Down's syndrome and behavioral problems in the offspring.
Hazards Summary
30 times as sweet as sucrose; [Hawley] An irritant; [MSDSonline] Removed from US market in 1969 because animal experiments showed increased bladder cancer; 75 subsequent studies failed to confirm this finding; It is approved for food use in Canada and 50 other countries around the world. [http://food.oregonstate.edu/glossary/c/cyclamate.html]
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity ProfileSODIUM CYCLAMATE is incompatible with strong oxidizing agents, strong acids and strong bases. Also incompatible with nitrites in acid solution. Has only limited compatibility with potassium salts (NTP, 1992).
化学と産業
薬理情報
MeSH Pharmacological ClassificationSubstances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)
用途と製造
Uses
Has been used as a non-nutritive sweetener; [Hawley]
Prohibited by US FDA for food use in 1969; [Hawley]
Use Classification
Food Additives -> SWEETENER -> JECFA Functional Classes
Cosmetics -> Masking
General Manufacturing InformationSulfamic acid, N-cyclohexyl-, sodium salt (1:1): ACTIVE
応用分野
解説チクロ，サイクラミン酸（シクロヘキシルスルファミン酸）のナトリウム塩，カルシウム塩の通称。合成甘味料の一種。無色〜白色の結晶または結晶性粉末で，水に可溶，砂糖の30〜50倍の甘味をもち，熱に安定。日本では前者は1956年，後者は1961年食品添加物として許可され，広く利用されてきたが，大量摂取は内臓障害や発癌のおそれがあるとされ，1969年使用禁止。その後の追試では発癌性に否定的であった。
用途人工甘味料
用途チクロ（サイクラミン酸ナトリウム）は、人工甘味料のひとつ。IUPAC名はN-シクロヘキシルスルファミン酸ナトリウム sodium N-cyclohexylsulfamate。甘さは砂糖の30倍から50倍といわれる。後味がわずかに苦い（特に高濃度の場合）が、サッカリンやアセスルファムカリウムほどではなく、それらの高甘味度甘味料に比べてすっきりした砂糖に近い甘味をもつ。
来歴Cyclamate was first synthesized in 1937. Like the other sweeteners, its sweet taste was accidentally discovered (U.S. Pat. 2,275,125 (Mar. 3, 1942), L. F. Andrieth and M. Sveda (to E. I. du Pont de Nemours & Co., Inc.). The FDA in 1958 classified sodium cyclamate as a GRAS sweetener. In 1969, a 2-year chronic toxicity study with a sodium cyclamate–sodium saccharin (10:1) mixture found bladder tumors in rats. The FDA took cyclamate off the GRAS list, banning it from foods and beverages, but permitting its sale in pharmacies. In 1970, after a congressional investigation, the FDA banned the use of cyclamate entirely. Abbott Laboratories, which has conducted additional toxicity and carcinogenicity studies with cyclamate, a 10:1 mixture of cyclamate–saccharin, and cyclohexylamine, claimed to be unable to confirm the 1969 findings. Abbott then filed a food additive petition for cyclamate in 1973, which was denied by the FDA in 1980. In 1982, the Calorie Control Council and Abbott Laboratories filed a second food additive petition containing the results of additional safety studies (The Calorie Control Council and Abbott Laboratories, Food Additive Petition for cyclamate 2A3672 (Sept. 22, 1982). That petition remains active.
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