キシレンスルホン酸ナトリウム

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Sodium Xylenesulfonate ... safe as cosmetic ingredient in the present practice of use and concentration as described in this safety assessment, when formulated to be nonirritating

Safe for use in cosmetics, with qualifications

Cough. Sore throat.

Redness.

Redness.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=1300-72-7]

Sodium Xylenesulfonate

TR-464: Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylenesulfonate (CASRN 1300-72-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) (1998 )

12/05/95

No Evidence

No Evidence

No Evidence

Xylenesulfonic acid, Na salt, (XSA) was tested for mutagenicity in Salmonella/microsome preincubation assay using a protocol approved by the National Toxicology Program. XSA was tested over a wide range of doses (0, 100, 333, 1000, 3333, and 10,000 ug/plate) in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. XSA was negative in these tests and the highest ineffective dose level tested in any Salmonella tester strain was 10,000 ug/plate.

... Conclusions: Under the conditions of these 2 yr dermal studies, there was no evidence of carcinogenic activity of sodium xylenesulfonate in male or female F344/N rats administered 60, 120 or 240 mg/kg or in male or female B6C3F1 mice administered 182, 364 or 727 mg/kg.

... Groups of 50 male and 50 female F344/N rats were dermally administered 0, 60, 120 or 240 mg sodium xylene sulfonate/kg bw in 50% ethanol for 104 wk. ... Groups of 50 male and 50 female B6C3F1 mice were dermally administered 0, 182, 364 or 727 mg sodium xylenesulfonate/kg bw in 50% ethanol for 104 to 105 wk. ... Conclusions: Under the conditions of these 2 yr dermal studies, there was no evidence of carcinogenic activity of sodium xylenesulfonate in male or female F344/N rats administered 60, 120 or 240 mg/kg or in male or female B6C3F1 mice administered 182, 364 or 727 mg/kg.