Sodium Iodate

Cosmetic ingredients (Sodium Iodate) -> CIR (Cosmetic Ingredient Review)

Preservative

4.28

4.277 @ 17.5°C

White, crystal powder

White rhombic crystals

Solubility in water: 9 g/100 cc @ 20 °C; 34 g/100 cc @ 100 °C; soluble in acetic acid; insol in alcohol

9.0 g/100g H2O at 25 °C

Danger

H272 (91.7%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

P210, P220, P233, P260, P261, P264, P270, P271, P272, P280, P284, P301+P317, P302+P352, P304+P340, P321, P330, P333+P317, P342+P316, P362+P364, P370+P378, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 72 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

Chemical: Iodic acid (HIO3), sodium salt

Status: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/25574

Sodium iodate: Does not have an individual approval but may be used under an appropriate group standard

An oxidizing agent; Fire hazard near organic substances; [Hawley] Toxic to retina after injection in animal studies; Iodate salts cause liver injury, hemoglobinuria, and renal failure in high-dose animal studies; Have similar hemolytic potential to chlorate and bromate salts; Chronic dosing can produce iodism with rhinitis, skin rashes, weight loss, palpitations, tremors, and occasionally symptoms of Graves disease; [HSDB] Causes convulsions, retinal changes, and proteinuria in intravenous, lethal-dose animal studies; [RTECS] An oxidizing agent; May cause fire on contact with combustible material; An irritant; May cause skin and respiratory sensitization after prolonged contact; Effects in high-dose animal studies include convulsions; [MSDSonline]

Ox. Sol. 2 (91.7%)

Acute toxicity (ingestion) - category 4

Oxidizing solids - Category 2

...OXYGEN-CONTAINING SUBSTANCES WHICH REACT VIOLENTLY OR EXPLOSIVELY INCLUDE SODIUM...IODATES...

MIXTURES OF SODIUM WITH SILVER OR SODIUM IODATES EXPLODE WHEN INITIATED BY SHOCK.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

0.39 [mg/m3]

4.3 [mg/m3]

26 [mg/m3]

ALTHOUGH OTHER OXIDIZING AGENTS HAVE NOT GENERALLY PROVED RETINOTOXIC, IT HAS BEEN SHOWN THAT INJURIOUS EFFECT OF IODATE IN EYE IS POTENTIZED BY OXIDIZING AGENT POTASSIUM PERMANGANATE, AND ANTAGONIZED BY REDUCING AGENT CYSTEINE, BUT NOT BY ADMINISTERING ASCORBIC ACID. /IODATE/

The safety of this ingredient has not been documented and substantiated. The CIR Expert Panel cannot conclude whether Sodium Iodate is safe for use in cosmetic products until the appropriate safety data have been obtained and evaluated.

Ingredients for which the data are insufficient and their use in cosmetics is not supported

...PT...GIVEN SEPTOJOD IV OR IP...HAD MARKED REDUCTION OF VISION WITHIN 24 HR. ...DEVELOPED DISTURBANCE OF RETINAL PIGMENT EPITHELIUM... IN MOST PT VISION EVENTUALLY IMPROVED...BUT IN MAJORITY CENTRAL SCOTOMA...OR CONSTRICTION OF VISUAL FIELDS PERSISTED... IODATE IN /SEPTOJOD/...RESPONSIBLE FOR OCULAR INJURIES. /IODATE/

PROLONGED USE OF IODINE PREPARATIONS...MAY LEAD TO IODISM. SYMPTOMS INCLUDE NASAL CATARRH, LACHRYMATION, SCRUFFINESS, SKIN RASHES...& LOSS OF APPETITE. OCCASIONALLY SYMPTOMS OF GRAVES' DISEASE ARE SEEN...PALPITATION OF HEART, TREMORS, SWEATING, & LOSS OF WT... /IODINE PREPN/

...ANIMAL EXPT SUGGEST THAT.../IODATE SALTS/ SHARE NEPHROTOXIC & HEMOLYTIC POTENTIAL OF CHLORATE & BROMATE. LARGE DOSES BY MOUTH REGULARLY PRODUCED EMESIS IN FASTED DOGS... /BROMATE/

NONSPECIFIC FATTY CHANGES WERE NOTED IN VISCERA, TOGETHER WITH NECROTIC LESIONS IN LIVER, KIDNEY, GI MUCOSA & URINARY BLADDER. IRREVERSIBLE RETINAL DEGENERATION ALSO OCCURRED /AMONG FASTED DOGS GIVEN LARGE DOSES OF IODATE SALTS BY MOUTH/. /BROMATE/

IODATE SALTS ARE 3-6 TIMES MORE ACUTELY TOXIC TO MICE THAN IODIDE SALTS. POTASSIUM & SODIUM IODATE HAVE ABOUT THE SAME LD50, & PRODUCE DEATH IN ACUTE RENAL FAILURE. SOMETIMES HEMOGLOBINURIA PRECEDED RENAL SHUTDOWN. /BROMATE/

For more Non-Human Toxicity Excerpts (Complete) data for SODIUM IODATE (10 total), please visit the HSDB record page.

LD50 Mouse ip 119 mg/kg

LD50 Mouse iv 108 mg/kg

NATRUM IODATUM

Osmotic Activity [MoA]; Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Increased Large Intestinal Motility [PE]; Osmotic Laxative [EPC]

WHEN IODATE (131)I HAS BEEN GIVEN INTRAVENOUSLY, LABELED IODINE HAS BEEN FOUND TO PASS RAPIDLY INTO AQUEOUS & VITREOUS HUMORS IN RABBITS. THAT REMAINING IN BLOOD PERSISTS FOR MANY HOURS & IS GRADUALLY REDUCED BY THE LIVER TO IODIDE. /IODATE/

WITHIN FEW MIN AFTER SINGLE IV DOSE THERE WAS MARKED INCR IN RATE OF PENETRATION OF SODIUM, IODINE & THIOUREA INTO VITREOUS BODY OF RABBIT, MAX EFFECT REACHED WITHIN 30-60 MIN. PATTERN OF ALTERED PERMEABILITY OF BLOOD-VITREAL BARRIER CONFIRMED IDEA OF EXCLUSIVE ATTACK ON CILIARY BODY.

EXPT RETINAL DEGENERATION INDUCED IN RABBITS BY DAILY INJECTIONS OF 30 MG/KG. IN 2-24 HR INTENSE FLUORESCEIN COLORATION APPEARED IN OUTER PART OF RETINA. IN 1-3 WK FLUORESCEIN PASSAGE INTO RETINA GRADUALLY DECR ALTHOUGH THE ALMOST VISUAL CELLS HAD DISAPPEARED.

ACCUM OF IODATE IN EYE TISSUES & FLUIDS AS POSSIBLE EXPLANATION OF RETINOTOXIC EFFECT OF IODATE WAS STUDIED BY IV INJECTION OF NAIO3 (30 MG/KG). EFFECT OF IODATE IS NOT DUE TO ACCUM OF IO3 IN EYE TISSUE, BUT TO DAMAGE TO BIOCHEM MECHANISMS INVOLVED IN REDN TO I-.

CIR ingredient: Sodium Iodate

Used as trace mineral additive in animal feeds and table salt; Also used as a disinfectant and antiseptic; [HSDB]

Using Disinfectants or Biocides [Category: Clean]

Trace mineral added to animal feeds, disinfectants, antiseptic

ADDITIVE IN TABLE SALT

Antiseptic for mucous membranes

Interaction of sodium chlorate & iodine in presence of nitric acid.

Prepared by oxidation of iodine to iodic acid followed by neutralization with an oxide or hydroxide; or by electrolytic oxidation of an iodide solution.

The article of commerce contains about 99% NaIO3.

Grades: CP, reagent, technical