基本情報
- CAS
59170-23-9- 標準SMILES
COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC- InChIKey
HXLAFSUPPDYFEO-UHFFFAOYSA-N- 分子式
- C20H27NO4
- 平均分子量
- 345.4 g/mol
- 単同位体質量
- 345.19400834
概要
Bevantolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, an anti-arrhythmia drug and a calcium channel blocker.
名称と識別子
- 優先名称
- Bevantolol
- IUPAC
- 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol
- 現地名
- 1-[[2-(3,4-ジメトキシフェニル)エチル]アミノ]-3-(3-メチルフェノキシ)-2-プロパノール
- 英語名
- Bevantolol
- 分子式
- C20H27NO4
- 分子量
- 345.43
名称と別名
Bevantolol59170-23-9Bevantololum1-(3,4-Dimethoxyphenethylamino)-3-(m-tolyloxy)-2-propanol(+-)-bevantolol1-((2-(3,4-Dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanolNSC-13234834ZXW6ZV211-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-methylphenoxy)propan-2-ol1-(3,4-dimethoxyphenethylamino)-3-m-tolyloxy-propan-2-olCHEBI:238698DTXSID70860597
名称をさらに表示
1-[[2-(3,4-ジメトキシフェニル)エチル]アミノ]-3-(3-メチルフェノキシ)-2-プロパノール1-[(3,4-ジメトキシフェネチル)アミノ]-3-(m-トリルオキシ)-2-プロパノール1-(3,4-ジメトキシフェネチルアミノ)-3-(3-メチルフェノキシ)-2-プロパノールベバントロール1-{[2-(3,4-ジメトキシフェニル)エチル]アミノ}-3-(3-メチルフェノキシ)プロパン-2-オールBevanolol.NSC 132348DL-BevantololBevantolol USP/EP/BP1-((3,4-DiMethoxyphenethyl)aMino)-3-(M-tolyloxy)propan-2-ol1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol1-(3,4-Dimethoxyphenethylamino)-3-(3-methylphenoxy)-2-propanol2-Propanol, 1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-
物性
構造計算による物性
- XLogP
- 3
- 極性表面積
- 60 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 5
- 回転可能結合数
- 10
- 重原子数
- 25
- 形式電荷
- 0
- 複雑度
- 355
実験および物理化学的性質
LogP
3.00
3.0
Solubility1.37e-02 g/L
Melting Point
137-138 °C
137 - 138 °C
Physical DescriptionSolid
物理化学的性質
- 貯蔵温度
- 2 · 2-8°C
- CAS データベース
- 59170 · 59170-23-9
化学と産業
薬理情報
ATC Code
C - Cardiovascular system
QC - Cardiovascular system
PharmacodynamicsBevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension.
Mechanism of Action
Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors. By binding and antagonizing beta-1 receptors Bevantolol inhibits the normal normal epinephrine-mediated sympathetic actions such as increased heart rate. This has the effect of decreasing preload and blood pressure.
MeSH Pharmacological ClassificationDrugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.
Cellular LocationsMembrane
Metabolite PathwaysBevantolol Action Pathway
上流・下流製品情報
上流原料
サプライヤー11 社
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
関連反応
2 件
化合物ノート
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