化工社化工社化学情報印刷レポート · 研究参考用

HCID 23749作成日：2026年11月3日

p-アゾベンゼンアルソン酸

p-アゾベンゼンアルソン酸 · (アゾビス-4,1-フェニレン)ビスアルソン酸 · アゾビス(4,1-フェニレン)ビスアルソン酸 · {4-[2-(4-アルソノフェニル)ジアゼン-1-イル]フェニル}アルソン酸 · p-Azobenzenearsonate · 4,4'-azodibenzenearsonic acid · Arsonic acid, As,As'-(1,2-diazenediyldi-4,1-phenylene)bis-

https://huagongshe.com/ja/chemical/23749

識別子と物理属性

CAS No.	7334-23-8
分子式	C12H12As2N2O6
平均分子量	430.08 g/mol
単同位体質量	429.91273 g/mol
SMILES	O=[As](O)(O)c1ccc(N=Nc2ccc([As](=O)(O)O)cc2)cc1
InChIKey	ITRMROGJSNWFKO-UHFFFAOYSA-N
PubChem CID	23749
ChEMBL	CHEMBL1449046
ChEBI	CHEBI:53554
DTXSID	DTXSID501028210
現地名	p-アゾベンゼンアルソン酸

化学・物理的性質

極性表面積	140
水素結合供与体数	4
水素結合受容体数	8
回転可能結合数	4
重原子数	22
形式電荷	0
複雑度	442
沸点	813.3±75.0 °C(Predicted)
pKa（酸解離定数）	2.95±0.10(Predicted)

安全性と法規制

Minimum Risk Level	Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)
Treatment	Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)
健康影響	Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)
暴露経路	Oral (L2)inhalation (L2)dermal (L2)
毒性の概要	Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)
Signs and Symptoms	Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of
Carcinogen Classification	3, not classifiable as to its carcinogenicity to humans. (L135)

p-アゾベンゼンアルソン酸

識別子と物理属性

CAS No.

7334-23-8

分子式

C12H12As2N2O6

平均分子量

430.08 g/mol

単同位体質量

429.91273 g/mol

SMILES

O=[As](O)(O)c1ccc(N=Nc2ccc([As](=O)(O)O)cc2)cc1

InChIKey

ITRMROGJSNWFKO-UHFFFAOYSA-N

PubChem CID

23749

ChEMBL

CHEMBL1449046

ChEBI

CHEBI:53554

DTXSID

DTXSID501028210

現地名

p-アゾベンゼンアルソン酸

極性表面積

140

水素結合供与体数

水素結合受容体数

回転可能結合数

重原子数

形式電荷

複雑度

442

沸点

813.3±75.0 °C(Predicted)

pKa（酸解離定数）

2.95±0.10(Predicted)

安全性と法規制

Minimum Risk Level

Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)

Treatment

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

健康影響

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)

暴露経路

Oral (L2)inhalation (L2)dermal (L2)

毒性の概要

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Signs and Symptoms

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of

Carcinogen Classification

3, not classifiable as to its carcinogenicity to humans. (L135)