モリンドン

WHITE CRYSTALLINE POWDER; FREELY SOL IN WATER & ALCOHOL /HYDROCHLORIDE/

4.74e-01 g/L

180-181 °C

180.5 °C

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Liver test abnormalities have been reported to occur in a small proportion of patients on long term therapy with molindone, but elevations are uncommonly above 3 times the upper limit of normal. The aminotransferase abnormalities are usually mild, asymptomatic and transient, reversing even with continuation of medication. Instances of clinically apparent acute liver injury have been reported due to molindone, but are rare. The onset of injury is within 4 to 8 weeks, and the pattern of serum enzyme elevations is typically hepatocellular. Jaundice is uncommon and most cases are self-limited and mild. Immunoallergic features and autoantibody formation are not typical.

TRANSIENT DROWSINESS IS MOST FREQUENT ADVERSE REACTION; PARKINSONIAN REACTIONS, RESTLESSNESS, INSOMNIA, DEPRESSION, BLURRED VISION, DRY MOUTH, NAUSEA & TACHYCARDIA OCCUR LESS FREQUENTLY. /HYDROCHLORIDE/

/IN ADDN TO PARKINSONIAN SYNDROME/, ANOTHER EXTRAPYRAMIDAL EFFECT SEEN DURING ANTIPSYCHOTIC DRUG THERAPY IS AKATHISIA. ... /IT/ REFERS TO COMPELLING NEED OF PT TO BE IN CONSTANT MOVEMENT RATHER THAN TO ANY SPECIFIC MOVEMENT PATTERN. ... /PT/ MAY BE UNABLE TO ... CONTROL /THIS EFFECT/. /ANTIPSYCHOTIC DRUGS/

ACUTE DYSTONIC REACTIONS ARE OCCASIONALLY SEEN WITH INITIATION OF ANTIPSYCHOTIC DRUG THERAPY. FACIAL GRIMACING & TORTICOLLIS CAN OCCUR & MAY BE ASSOCIATED WITH OCULOGYRIC CRISIS. /ANTIPSYCHOTIC DRUGS/

TARDIVE DYSKINESIA IS LATE-APPEARING NEUROLOGICAL SYNDROME ASSOCIATED WITH ANTIPSYCHOTIC DRUG USE. IT OCCURS MORE FREQUENTLY IN OLDER PT, & AN INCIDENCE AS HIGH AS 20% HAS BEEN REPORTED IN CHRONICALLY INSTITUTIONALIZED PT. IT MAY BE MORE COMMON IN FEMALES & THOSE WITH HISTORY OF PRIOR BRAIN DAMAGE. /ANTIPSYCHOTIC DRUGS/

For more Human Toxicity Excerpts (Complete) data for MOLINDONE (7 total), please visit the HSDB record page.

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

Molindone

DILI Positive

Oral

DOI:10.1016/j.drudis.2019.09.022

N - Nervous system

QN - Nervous system

Molindone is a dihydroindolone compound which is not structurally related to the phenothiazines, the butyrophenones, or the thioxanthenes. Molindone has a pharmacological profile in laboratory animals which predominantly resembles that of major tranquilizers causing reduction of spontaneous locomotion and aggressiveness, suppression of a conditioned response and antagonism of the bizarre stereotyped behavior and hyperactivity induced by amphetamines. In addition, molindone antagonizes the depression caused by the tranquilizing agent tetrabenazine.

The exact mechanism has not been established, however, based on electroencephalogram (EEG) studies, molindone is thought to act by occupying (antagonizing) dopamine (D2) receptor sites in the reticular limbic systems in the brain, thus decreasing dopamine activity. Decreased dopamine activity results in decreased physiological effects normally induced by excessive dopamine stimulation, such as those typically seen in manifestations of psychotic disorders.

INFORMATION IS INADEQUATE TO DETERMINE SPECIFIC ACTIONS OF MOLINDONE...

THIS ANTIPSYCHOTIC AGENT IS A DIHYDROINDOLONE DERIV. IT IS NOT CHEM RELATED TO PHENOTHIAZINES, BUTYROPHENONES OR THIOXANTHENES, BUT PHARMACOLOGIC ACTIONS ARE SIMILAR TO THOSE OF PIPERAZINE PHENOTHIAZINES.

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MOLINDONE

Established Pharmacologic Class [EPC] - Typical Antipsychotic

Molindone is a Typical Antipsychotic.

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Rapidly absorbed from the gastrointestinal tract following oral administration.

Human metabolic studies show molindone to be rapidly absorbed and metabolized when given orally. There are 36 recognized metabolites with less than 2-3% unmetabolized molindone being excreted in urine and feces.

REACHES PEAK BLOOD LEVELS WITHIN 1 HR AFTER ORAL ADMIN.