| GHS 分類 | Not ClassifiedAggregated GHS information provided per 808 reports by companies from 18 notifications to the ECHA C&L Inventory.DangerH228: Flammable solid [Danger Flammable solids]P210, P222, P231, P233, P235, P240, P241, P280, P302+P335+P334, P370+P378, P407, P410, P413, and P420 (click each P-code to see the statement) |
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| 規制情報 | Chemical: TitaniumTitanium is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Titanium are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 10-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15537Titanium: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| その他の安全情報 | IMAP assessments - Titanium: Human health tier I assessment |
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| 輸送ラベル（DOT） | Spontaneously CombustibleFlammable Solid |
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| 火災危険 | Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:Excerpt from ERG Guide 170 [Metals (Powders, Dusts, Shavings, Borings, Turnings, or Cuttings, etc.)]:· Flammable/combustible material.· May react violently or explosively on contact with water. |
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| 火災の可能性 | The dust may ignite spontaneously in air. Flammable when exposed to heat or flame or by chemical reaction. Titanium can burn in an atmosphere of carbon dioxide, nitrogen, or air.TITANIUM BURNS VIGOROUSLY IN FREE NITROGEN ABOVE 802 °C. ... @ RED HEAT, 704 °C, DECOMPOSES STEAM. HYDROGEN EVOLVED BURNS OR EXPLODES. ... MIXTURE OF TITANIUM POWDER WITH TRICHLOROETHYLENE OR WITH TRICHLOROTRIFLUOROETHANE WILL FLASH OR SPARK ON HEAVY IMPACT.MOST FINELY DIVIDED FORMS OF TITANIUM ARE FLAMMABLE IN AIR. ... IGNITED WHEN GLASS CONTAINER OF POWDER WAS THROWN @ WALL WITH FORCE SUFFICIENT TO BREAK CONTAINER. POWDERED ... TITANIUM ... ALL REACT WITH BROMINE TRIFLUORIDE, PRODUCING INCANDESCENCE. TITANIUM BURNS IN CARBON DIOXIDE ABOVE 550 °C.WHEN TITANIUM IS FRACTURED IN LIQUID FLUORINE ATMOSPHERE IT IGNITES. WITH CATALYSTS, TITANIUM HAS IGNITED IN GASEOUS FLUORINE @ -113 °F. |
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| 健康有害性 | Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:Excerpt from ERG Guide 170 [Metals (Powders, Dusts, Shavings, Borings, Turnings, or Cuttings, etc.)]:· Fire will produce irritating, corrosive and/or toxic gases.· Oxides from metallic fires are a severe health hazard. |
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| 有害性の概要 | Not known to be an essential trace mineral in the dietTitanium tetrachloride is a strong skin and respiratory tract irritantTitanium carbide, hydride, nitride, and boride have shown slight fibrogenic activity in studies of experimental animalsInjection of titanium metal into rats has induced fibrosarcomas and lymphosarcomasA 3-generation study of reproductive toxicity in rats showed some effects after chronic feedingTitanium dioxide dust has generally been found not fibrogenic and not carcinogenic in epidemiological studiesThere is sufficient evidence in animal studies that titanium dioxide is carcinogenic (IARC 2B)[Nordberg, p. 1287-94] See Titanium dioxide. |
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| 輸送番号・ガイド（DOT） | 2546 1351352 170 |
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| 反応性グループ | Metals, Elemental and Powder, Active |
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| Special Reports | BERLIN MUS ENVIRON PROT AGENCY, OFF RES DEV, (REP) EPAEPA-600/1-77-022, TOXICOL MET VOL 2PB-268 324, 427 (1977). REVIEW OF TITANIUM TOXICOLOGY.WHOEnviron Health Criteria: Titanium (1982) |
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| Reactivity Alerts | Strong Reducing AgentHighly Flammable |
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| Reactivity Profile | TITANIUM reacts violently with cupric oxide and lead oxide when heated. When titanium is heated with potassium chlorate, potassium nitrate, or potassium permanganate, an explosion occurs [Mellor 7:20. 1946-47]. The residue from the reaction of titanium with red fuming nitric acid exploded violently when the flask was touched [Allison 1969]. Liquid oxygen gives a detonable mixture when combined with powdered titanium, [Kirchenbaum 1956].TITANIUM is a reducing agent. Powdering increases its reactivity. Wetting reduces the reactivity of the powder. Titanium reacts violently with cupric oxide and lead oxide when heated. When titanium is heated with potassium chlorate, potassium nitrate, or potassium permanganate, an explosion occurs [Mellor 7:20. 1946-47]. The residue from the reaction of titanium with red fuming nitric acid exploded violently when the flask was touched [Allison 1969]. Liquid oxygen gives a detonable mixture when combined with powdered titanium, [Kirchenbaum 1956]. |
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| 消火 | Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:Excerpt from ERG Guide 170 [Metals (Powders, Dusts, Shavings, Borings, Turnings, or Cuttings, etc.)]: |
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| 漏出応急措置 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
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| 応急処置 | Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:Excerpt from ERG Guide 170 [Metals (Powders, Dusts, Shavings, Borings, Turnings, or Cuttings, etc.)]:General First Aid: |
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| 暴露管理・個人防護 | · Wear positive pressure self-contained breathing apparatus (SCBA). |
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| 消火手順 | ORDINARY EXTINGUISHERS ARE OFTEN INEFFECTIVE AGAINST TITANIUM FIRES. SUCH FIRES REQUIRE SPECIAL EXTINGUISHERS DESIGNED FOR METAL FIRES. IN AIRTIGHT ENCLOSURES TITANIUM FIRES CAN BE CONTROLLED BY THE USE OF ARGON OR HELIUM. TITANIUM, IN THE ABSENCE OF MOISTURE, BURNS SLOWLY, BUT EVOLVES MUCH HEAT.DO NOT USE WATER OR CARBON DIOXIDE TO EXTINGUISH.If material on fire or involved in fire: Cool all affected containers with flooding quantities of water. Use graphite, soda ash, powdered sodium chloride, or suitable dry powder. /Titanium powder, wetted/If material on fire or involved in fire: Do not use water. Use graphite, soda ash, powdered sodium chloride, or suitable dry powder. /Titanium powder, dry/ |
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| 非火災時の漏出対応 | Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:Excerpt from ERG Guide 170 [Metals (Powders, Dusts, Shavings, Borings, Turnings, or Cuttings, etc.)]: |
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| 処分方法 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Preventive Measures | ADEQUATE VENTILATION & LUBRICATION SHOULD BE PROVIDED DURING SAWING, GRINDING & POLISHING OF TITANIUM METAL.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Keep material wet. /Titanium powder, dry/If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Keep material wet. /Titanium powder, wetted/Personnel protection: ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Titanium powder, drytitanium powder, wetted/ |
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| Isolation and Evacuation | Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:Excerpt from ERG Guide 170 [Metals (Powders, Dusts, Shavings, Borings, Turnings, or Cuttings, etc.)]:Immediate precautionary measure |
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| Protective Action Criteria (PAC) | 15 [mg/m3]170 [mg/m3]990 [mg/m3] |
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| Personal Protective Equipment (PPE) | Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:Excerpt from ERG Guide 170 [Metals (Powders, Dusts, Shavings, Borings, Turnings, or Cuttings, etc.)]:WORKERS SHOULD ALSO WEAR PERSONAL & RESPIRATORY PROTECTIVE EQUIPMENT WHERE NECESSARY. |
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| Emergency Response Planning Guidelines | · DO NOT USE WATER, CO2 OR FOAM ON MATERIAL ITSELF.· DO NOT USE WATER, FOAM OR CO2. |
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| 相互作用 | ... REPORT OF LUNG CHANGES IN ANIMALS EXPOSED FOR 5 MO TO TITANIUM COMBINED WITH CARBON. CHANGES WERE SAID TO RESEMBLE SILICOSIS, LESIONS NOT FOUND IN ANIMALS EXPOSED FOR SEVERAL YR TO DUST OF ... CARBOLOY WHICH CONTAINS TITANIUM CARBON CMPD ... . |
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| Human Toxicity Excerpts | /INVESTIGATOR/ ... STUDIED CASE OF CHRONIC LUNG DISEASE IN WORKER EXPOSED TO SEVERAL METALS ... TITANIUM WAS FOUND IN LUNG BIOPSY.LACK OF TOXICITY ... BY CONTACT WITH SKIN & TISSUES HAS BEEN ... DEMONSTRATED BY ITS USE IN THERAPY OF SKIN DISORDERS & IN SURGICAL APPLIANCES.Food is considered to be the principal source of titanium exposure for humans. The chemical and biological kinetics and metabolism of titanium are discussed. The only carcinogenic effects of titanium thus far reported have been the development of fibrosarcomas at the injection sites in exposed rats. There is no evidence that titanium is carcinogenic in humans. /It was concluded/ that the current extent of exposure to titanium of the general population does not pose a health risk. |
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| Non-Human Toxicity Excerpts | DISKS OF TITANIUM METAL IMPLANTED IN MUSCLE OF DOGS & LEFT IN SITU FOR 7 MO WERE INERTWOUND HEALED & METAL WAS ENCAPSULATED WITH FIBROUS TISSUE.INHALATION /OF TITANIUM DUST/ HAS CAUSED ONLY SLIGHT LESIONS OF LUNG ... .... INERTNESS & LACK OF RESPONSE IN BONE TISSUE HAS ... BEEN SHOWN BY RESULTS OF PLATING & FIXATION OF FRACTURES IN DOGS BY TITANIUM PLATES & SCREWS.CARCINOGENICITY STUDIES WERE PERFORMED ON 50 RATS USING 6 MONTHLY INTRAMUSCULAR DOSES EACH CONTAINING 6 MG OF TITANIUM METAL POWDER SUSPENDED IN 0.2 ML OF TRIOCTANOIN. INCR RATES OF FIBROSARCOMAS & LYMPHOSARCOMAS WERE OBSERVED IN RATS, WHICH SURVIVED UP TO 820 DAYS COMPARED WITH CONTROLS.For more Non-Human Toxicity Excerpts (Complete) data for TITANIUM (7 total), please visit the HSDB record page. |
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| Probable Routes of Human Exposure | ... EXPOSURE TO TITANIUM IS MAINLY ASSOC WITH METAL, DIOXIDE, CARBIDE, OR TETRACHLORIDE. EXPOSURE ... USUALLY IN FORM OF DUST BUT EXPOSURES TO FUMES & VAPORS OCCUR DURING HANDLING OF TITANIUM TETRACHLORIDE. |
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| Antidote and Emergency Treatment | Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/ |
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| EPA Provisional Peer-Reviewed Toxicity Values | TitaniumPDF Document2010 |
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