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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 23969作成日：2026年10月27日

Arsine

trihydridoarsenic(.1+)

https://huagongshe.com/ja/chemical/23969

Arsine の分子構造式

識別子と物理属性

CAS No.127323-69-7
分子式AsH3
平均分子量77.946 g/mol
単同位体質量77.94507 g/mol
SMILES[AsH3]
InChIKeyRBFQJDQYXXHULB-UHFFFAOYSA-N
PubChem CID23969
ChEBICHEBI:47217
EC No.232-066-3
DTXSIDDTXSID3023760

化学・物理的性質

極性表面積0
水素結合供与体数0
水素結合受容体数0
回転可能結合数0
重原子数1
形式電荷0
複雑度0
物質分類Toxic Gases & Vapors -> HydridesCarcinogens-> NIOSH Emergency Response Categories
pHAqueous solutions are neutral
SpringerMaterials Propertiesnuclear quadrupole moment
農薬Pesticide -> EPA IRIS
臭いDisagreeable garlic odor
密度1.689 at 185 °F (EPA, 1998) - Denser than waterwill sink3.186 g/L (gas)3.186 @25 °C2.69(relative gas density)
ViscosityViscosity of the gas at 101.325 kPa at 0 °C: 0.01458 mPaXs, 0.01458 mNXs/sq m
Color/FormColorless gasColorless gas ... [Note: Shipped as a liquefied compressed gas].
溶解度20 cc/100 cc (NTP, 1992)In water, 28 mg/100 mL at 20 °CSlightly soluble in alcohol and alkaliesSoluble in chloroform and benzeneSolubility in water, ml/100ml at 20 °C: 20 (very slightly soluble)20%
引火点Flammable gasNA (Gas)
沸点-80.4 °F at 760 mmHg (EPA, 1998)-62.5 °C-62 °C-81 °F-62.5 °C @760 [mm Hg]
DecompositionWhen heated to decomposition it emits highly toxic fumes of /arsenic/.Decomposition product: arsenic when arsine is heated to decomposition pointarsenic when arsine is exposed to light.Decomposition point: 300 °C

安全性と法規制

GHS 分類DangerH220: Extremely flammable gas [Danger Flammable gases]P203, P210, P222, P260, P271, P273, P280, P284, P304+P340, P316, P319, P320, P377, P381, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement)H220 (100%): Extremely flammable gas [Danger Flammable gases]P203, P210, P222, P260, P264, P270, P271, P273, P280, P284, P304+P340, P308+P316, P316, P319, P320, P321, P377, P381, P391, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)
Hazards IdentificationToxic/poison by inhalation (TIH/PIH)
規制情報Chemical: ArsineHazard Traits - Cardiovascular ToxicityDermatotoxicityNeurotoxicityRespiratory ToxicityArsine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Arsine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)REACH registered substance: Arsine (EC: 232-066-3)Restricted substance: ArsineArsine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
その他の安全情報IMAP assessments - Arsine: Human health tier II assessment- Indoor Air: Arsine (SA) can be released into indoor air as a gas.
輸送ラベル（DOT）Poison Gas Flammable Gas
火災危険For information on chemical warfare blood agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)· Flammablemay be ignited by heat, sparks or flames.Extremely flammable. Gas/air mixtures are explosive. Explosive.
火災の可能性Flammable when exposed to flame.Arsine is an extremely flammable gas and may be ignited by sparks and flame. Flammable vapor may spread from spill area.
健康有害性For information on chemical warfare blood agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
· TOXIC
may be fatal if inhaled or absorbed through skin. Some may cause severe skin burns and eye damage.
有害性の概要Arsine is a colorless, flammable, and highly toxic gas. It has a garlic-like or fishy odor that can be detected at concentrations of 0.5 ppm and above. Because arsine is nonirritating and produces no immediate symptoms, persons exposed to hazardous levels may be unaware of its presence. Arsine is water soluble. It is generally shipped in cylinders as a liquefied compressed gas. Exposure frequently occurs when arsine gas is generated while metals or crude ores containing arsenic impurities are treated with acid and this is a common source of exposure. Synonyms include arsenic hydride, arsenic trihydride, arseniuretted hydrogen, arsenious hydride, and hydrogen arsenide.Arsine damages the cell membrane of the red blood cell resulting in hemolysis. Since arsine is soluble, versus insoluble arsenic compounds, it is not as likely to be retained in the lung and increase the risk of lung cancer. [ACGIH] Acute arsine poisoning may induce acute tubular necrosis secondary to hemoglobinuria. [LaDou, p. 418] Two workers in a smelter suffered from arsine poisoning. The first patient had methemoglobinemia and hemoglobinuria at the time of hospital admission with complete resolution two weeks after exposure. [HSDB] Possible frostbite from contact with liquid[NIOSH] See Arsenic and the linked occupational diseases.
輸送番号・ガイド（DOT）2188 119
反応性グループReducing Agents, Strong
UN 分類UN Hazard Class: 2.3UN Subsidiary Risks: 2.1
Explosion Hazards- Arsine (SA) is explosive.
消火For information on chemical warfare blood agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)Shut off supplyif not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with powder, carbon dioxide. In case of fire: keep cylinder cool by spraying with water. Combat fire from a sheltered position.- Arsine is flammable.
応急処置措置Fresh air, rest. Refer immediately for medical attention.ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer immediately for medical attention.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
漏出応急措置· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
応急処置For information on chemical warfare blood agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)General First Aid:(General first aid procedures)
安全保管Fireproof if in building. Cool. Ventilation along the floor.
Firefighting HazardsContainer may explode in heat of fire. Vapor explosion and poison hazard exists indoors, outdoors, and in sewers.
暴露管理・個人防護· Wear positive pressure self-contained breathing apparatus (SCBA).TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].13.0 [ppm]
消火手順If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Solid streams of water may be ineffective. Use "alcohol" foam, dry chemical, or carbon dioxide.Stop flow of gas before extinguishing fire. Approach release from upwind. Eliminate all ignition sources. Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors and protect personnel.
保管条件Store in areas clear of food or food products and combustible materials.
清掃方法Cleanup methods: arsine (1-20 ppm) is removed from process ventilated exhaust air from copper electrolytic purification cells by counter-current wet scrubbing.Cleanup methods: arsine- or phosphine-containing waste gas is purified by bubbling through an arsenic trichloride or phosphorus trichloride solution, then the treated gas is bubbled through water or an alkaline solution. The removal is complete.Releases may require isolation or evacuation. Approach release from upwind. eliminate all ignition sources. Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors and protect personnel.
非火災時の漏出対応For information on chemical warfare blood agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Arsine may be disposed of by controlled burning. When possible, cylinders should be sealed and returned to supplier.
TreatmentThere is no antidote for arsine. Treatment is symptomatic and consists of measures to support respiratory, vascular, and renal function. Whole blood transfusions may be effective if significant haemolysis has occurred. (L11)
Cancer Sites[lung & lymphatic cancer]
相互作用In this study the effect of sulfur, sulfur compounds, thiol-containing compounds, and thiol inhibitors on AsH(3)-induced disruption of membrane transport and hemolysis in human erythrocytes was investigated in vitro. Elemental sulfur, sodium thiosulfate, 5, 5'-dithio-bis(2-nitrobenzoic acid), and meso-2,3-dimercaptosuccinic acid were successful in delaying hemolysis, but the most successful agent was the sulfhydryl inhibitor, N-ethylmaleimide (NEM). This indicated that sulfhydryl groups, possibly membrane sulfhydryls, are major factors in the hemolytic mechanism of AsH(3). Measuring intracellular ion concentrations tested the effect of NEM on AsH(3)-induced disruption of membrane transport. AsH(3) alone caused all ions tested to flow with their concentration gradients: Intracellular K+ and Mg++ decreased, whereas Na+, Cl-, and Ca++ increased. NEM was unable to prevent ion loss except for Ca++, whose increase was prevented for 1 hr after AsH(3) treatment. The influx of Ca++ in AsH(3)-treated erythrocytes is an irreversible event leading to hemolysis. Reduction of oxygenated hemoglobin to carboxyhemoglobin completely inhibited AsH(3)-induced hemolysis. In addition, AsH(3) and NEM had no direct chemical interactions. We concluded that membrane sulfhydryl groups are likely targets of AsH(3) toxicity, with NEM being able to prevent AsH(3)-induced hemolysis.
標的器官HematologicBlood, kidneys, liver
健康影響Arsine exposure causes haemolytic anaemia, polyneuropathy, hypotension, and damage to the lungs, kidneys, liver, nervous system, heart, and blood-forming organs. (L11)
有害作用Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.
暴露経路The substance can be absorbed into the body by inhalation.inhalation, skin and/or eye contact (liquid)Arsine (SA) can be absorbed into the body by inhalation. Ingestion is unlikely because arsine (SA) is a gas at room temperature. Metal arsenides are solids that can be ingestedthey can react with stomach acids to release arsine (SA) gas. Information is limited about absorption of arsine (SA) through, or arsine’s (SA) toxic effects on, the skin or eyes.
毒性の概要IDENTIFICATION: Arsine is a colorless, extremely flammable gas with a garlic odor. The gas is heavier than air and accumulates close to the surface, which makes distant ignition possible in the presence of flame or spark. Arsine is extensively used in the semiconductor industry for epitaxial growth of gallium arsenide, as a doping agent for silicon based solid state electronic devices and the manufacture of light emitting diodes. HUMAN EXPOSURE: In humans arsine is absorbed via the lungs and mucosal surface of the respiratory tract. After exposure, the concentration of arsine increases rapidly in blood, whereas the distribution to the liver, kidneys and other organs is much slower. In humans, arsine is metabolized to trivalent and pentavalent arsenic. Trivalent arsenic is methylated to monomethylarsonate and dimethylarsinate. Arsine metabolites are mainly excreted via urine. Arsine in humans induces hemolysis with an increase in plasma hemoglobin, iron and potassium and subsequent anemia and kidney damage. No reliable information is available on exposure levels at which these effects occur. Myocardial and pulmonary failures are other causes of death. Severe liver lesions are rare. Anemia is observed accompanied by Heinz-Ehrlich corpuscles and increased leukocytosis. Hemoglobin, hemosiderin, erythrocytes, proteins and casts, found in urine. There are no data on the carcinogenicity or mutagenicity of arsine in humans. ANIMAL STUDIES: In animals, arsine is absorbed via the lungs and respiratory tract. In animals exposed to arsine, the concentration of arsine increases rapidly in blood, whereas distribution to liver, kidneys and lungs and other organs is much slower. In animals, arsine is metabolized to trivalent and pentavalent arsenic. Trivalent arsenic is methylated to monomethylarsonate and dimethylarsinate. These metabolites are mainly excreted via urine. The acute toxicity of arsine in different species is high. Inhalation of arsine by mice caused an increase in the relative spleen weight and a decrease in hematocrit. Histopathological changes observed included hemosiderosis and extramedullary hematopoietic activity in the spleen. Repeated exposure to arsine caused persistent splenomegaly and slight suppression of bone marrow erythroid precursors in rats, mice and Syrian Golden hamsters. Methemoglobinemia was noted in mice. In one study arsine did not induce developmental toxicity in mice or rats. There are no data on the carcinogenicity or mutagenicity in animals.Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. Arsine may also inhibit catalase, which leads to the accumulation of hydrogen peroxide. This destroys red cell membranes and may contribute to arsine-induced conversion of Fe+2 to Fe+3, which also impairs oxygen transport. (L11)
Signs and SymptomsAbdominal pain. Confusion. Dizziness. Headache. Nausea. Shortness of breath. Vomiting. Weakness. Symptoms may be delayed.ON CONTACT WITH LIQUID: FROSTBITE.headache, malaise (vague feeling of discomfort), lassitude (weakness, exhaustion), dizzinessdyspnea (breathing difficulty)abdominal, back painnausea, vomitingbronze skinhematuria (blood in the urine)jaundiceperipheral neuropathyliquid: frostbite[potential occupational carcinogen]- Contact with the eyes does not normally result in whole-body (systemic) toxicity.- Arsine (SA) is present as a gas at room temperature, so ingestion is unlikely.
Effluent ConcentrationsArsine was present in sewage sludge from a municipal wastewater treatment plant in Ruhrgebiet, Germany at a concentration of 0.76 ng/L. The compound was produced by pure cultures of anaerobic sewage sludge micorflora Methanobacterium formicicum, Methanosarcina, and Methanobacterium thermoautotrophicumamounts of volatile arsine were 0.06-9.6, 0.2-1.0, and 0.073-12.6 ng, respectively(1).
ICSC Environmental DataIt is strongly advised not to let the chemical enter into the environment.
EPA IRIS InformationArsineHematologic5 x 10 ^-5 mg/m^3
RCRA 要件D004A waste containing arsenic (such as arsine) may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations.
大気基準Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Arsine is included on this list.
CERCLA 報告数量Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Arsine is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 lbs.
清浄水法要件Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic and cmpd/For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/
DHS Chemicals of Interest (COI)Arsine110000.6715Toxic chemical that can be released at a facility.
Federal Drinking Water Standards10 ug/l /Arsenic/