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HCID 24009作成日：2026年10月27日

Phosphoric acid, lead(2+) salt (2:3)

https://huagongshe.com/ja/chemical/24009

Phosphoric acid, lead(2+) salt (2:3) の分子構造式

識別子と物理属性

CAS No.7446-27-7
分子式P2Pb3O8
平均分子量810 g/mol
単同位体質量813.83679652 g/mol
SMILESO=P([O-])([O-])[O-].O=P([O-])([O-])[O-].[Pb+2].[Pb+2].[Pb+2]
InChIKeyHUTDDBSSHVOYJR-UHFFFAOYSA-H
PubChem CID24009
EC No.231-205-5
DTXSIDDTXSID5064706

化学・物理的性質

極性表面積173
水素結合供与体数0
水素結合受容体数8
回転可能結合数0
重原子数13
形式電荷0
複雑度36.8
物質分類Metals -> Lead Compounds, InorganicCarcinogens
密度6.9 g/cu cm6.9-7.3 @25 °C
Color/FormWhite powder
溶解度Insol in alcoholsol in nitric acid, fixed alkali hydroxides0.000014 g/100 cu cm water @ 20 °CInsoluble in ethanol
DecompositionWhen heated to decomp ... emits very toxic fumes of /lead and phosphorus oxides/.
融点1,014 °C1014 °C
屈折率Indices of refraction: 2.048, 2.058 /Pyromorphite/
Physical DescriptionLead phosphate is a white powder.White solid[Merck Index] Practically insoluble in water (0.14 mg/L at 20 deg C)[ATSDR ToxProfiles]
Other Experimental PropertiesLead is derived from the decay of radon. /Inorganic lead/Natural lead is a mixture of four stable isotopes: Pb-204 (1.4%), Pb-206 (25.2%), Pb-207 (21.7%) and Pb-208 (51.7%). Lead isotopes are the end-products of each of the three series of naturally occurring radioactive elements: Pb-206 for the uranium series, Pb-207 for the actinium series and Pb-208 for the thorium series. Forty-three other isotopes of lead, all of which are radioactive, are recognized.

安全性と法規制

GHS 分類DangerH360Df: May damage the unborn childSuspected of damaging fertility [Danger Reproductive toxicity]P203, P260, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)H351: Suspected of causing cancer [Warning Carcinogenicity]P203, P260, P264, P270, P280, P308+P316, P318, P319, P321, P405, and P501 (click each P-code to see the statement)
規制情報Chemical: Phosphoric acid, lead(2+) salt (2:3)Hazard Traits - CarcinogenicityReproductive ToxicityRestricted substance: Trilead bis(orthophosphate)Lead phosphate: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
その他の安全情報IMAP assessments - Selected lead-based pigments: Human health tier II assessment
輸送ラベル（DOT）Poison
火災危険Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
健康有害性Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
有害性の概要Toxic material[Hawley] See Lead and linked occupational diseases.
反応性グループSalts, Basic
Special ReportsNational Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Lead and Lead Compounds are listed as reasonably anticipated to be human carcinogens. /Lead and Lead Compounds/[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s101lead.pdf]IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol 87 Inorganic and Organic Lead Compounds Geneva: World Health Organization, International Agency for Research on Cancer, (2006). IARC Monographs provide critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations.
RCRA 要件U145As stipulated in 40 CFR 261.33, when lead phosphate, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).D008A solid waste containing lead may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Lead/The Environmental Protection Agency is ... /promulgated/ regulations concerning ground-water monitoring with regard to screening suspected contamination at land based hazardous waste treatment, storage, and disposal facilities. ... /There are/ new requirements to analyze for a specified core list of chemicals plus those chemicals specified by the Regional Administrator on a site-specific basis. ... /Total lead (all species) is included on this list./ /Total lead (all species)/
OSHA StandardsPermissible Exposure Limit: The employer shall assure that no employee is exposed to lead at concentrations greater than 50 ug/cu m of air averaged over an 8-hr period. If an employee is exposed to lead for more than 8 hr in any work day, the permissible exposure limit, as a TWA for that day, shall be reduced according to the following formula: Maximum permissible limit (in ug/cu m)=400 divided by the number of hours worked in the day. /Lead, inorganic, as Pb/The employer shall remove an employee from work having an exposure to lead at or above the action level on each occasion that a periodic and a follow-up blood sampling test conducted pursuant to this section indicate that the employee's blood lead level is at or above 60 ug/100 g of whole bloodand, the employer shall remove an employee from work having an exposure to lead at or above the action level on each occasion that the average of the last three blood sampling tests conducted pursuant to this section (or the average of all blood sampling tests conducted over the previous six (6) months, whichever is longer) indicates that the employee's blood lead level is at or above 50 ug/100 g of whole bloodprovided, however, that an employee need not be removed if the last blood sampling test indicates a blood lead level at or below 40 ug/100 g of whole blood. ... The employer shall return an employee to his or her former job status: ... when two consecutive blood sampling tests indicate that the employee's blood lead level is at or below 40 ug/100 g of whole blood. ... The employer shall provide to an employee up to eighteen (18) months of medical removal protection benefits on each occasion that an employee is removed from exposure to lead or otherwise limited pursuant to this section. /Lead, inorganic, as Pb/Permissible Exposure Limit: The employer shall assure that no employee is exposed to lead at concentrations greater than 50 ug/cu m of air averaged over an 8-hr period. If an employee is exposed to lead for more than 8 hr in any work day, the permissible exposure limit, as a TWA for that day, shall be reduced according to the following formula: Maximum permissible limit (in ug/cu m)=400 divided by the number of hours worked in the day. /Lead, inorganic, as PbShipyard Employment/provided, however, that an employee need not be removed if the last blood sampling test indicates a blood lead level at or below 40 ug/100 g of whole blood. ... The employer shall return an employee to his or her former job status: ... when two consecutive blood sampling tests indicate that the employee's blood lead level is at or below 40 ug/100 g of whole blood. ... The employer shall provide to an employee up to eighteen (18) months of medical removal protection benefits on each occasion that an employee is removed from exposure to lead or otherwise limited pursuant to this section. /Lead, inorganic, as PbShipyard Empolyment/For more OSHA Standards (Complete) data for LEAD PHOSPHATE (6 total), please visit the HSDB record page.
Reactivity ProfileSalts, basic, such as LEAD PHOSPHATE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
大気基準National primary and secondary ambient air quality standards for lead and its compounds, measured as elemental lead by a reference method based on appendix G to this part, or by an equivalent method, are: 1.5 micrograms per cubic meter, maximum arithmetic mean averaged over a calendar quarter. /Lead and its compounds, as Pb/Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Lead compounds are included on this list. /Lead compounds/
消火Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
応急処置Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
暴露管理・個人防護Biological Exposure Indices (BEI) [ACGIH] - Lead in blood = 200 ug/L (20 ug/100 ml)sampling time not critical
消火手順Use dry chemical, carbon dioxide, water spray, or extinguishers ... If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officeals and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position.
保管条件Lead phosphate must be stored to avoid contact with oxidizers (such as perchlorates, peroxides, permanganates, chlorates, and nitrates) and chemically active metals (such as potassium, sodium, magnesium, and zinc) since violent reactions occur. A regulated, marked area should be established where this chemical is handled, used, or stored ...PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
清掃方法Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/
非火災時の漏出対応Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
処分方法Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U145, D008, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.A poor candidate for incineration.PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/For more Disposal Methods (Complete) data for LEAD PHOSPHATE (7 total), please visit the HSDB record page.
Preventive MeasuresLead phosphate is a carcinogenhandle with extreme caution. Lead phosphate should be handled as a teratogen, with extreme caution.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emmissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... Clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/For more Preventive Measures (Complete) data for LEAD PHOSPHATE (16 total), please visit the HSDB record page.
Isolation and EvacuationExcerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
Minimum Risk LevelChronic Inhalation: 0.05 mg/m3 (L134)
Threshold Limit Values (TLV)0.05 [mg/m3], as Pb8 hr Time Weighted Avg (TWA): 0.05 mg/cu m. /Lead, and inorganic compounds, as Pb/Excursion Limit Recommendation: Excursions in worker exposure levels may exceed three times the TLV-TWA for no more than a total of 30 min during a work day, and under no circumstances should they exceed five times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Lead, inorganic compounds, as Pb/A3Confirmed animal carcinogen with unknown relevance to humans. /Lead, elemental, and inorganic compounds, as Pb/Biological Exposure Index (BEI): Determinant: lead in bloodSampling Time: not criticalBEI: 30 ug/100 mL. [Note: Women of child bearing potential, whose blood Pb exceeds 10 ug/dL, are at risk of delivering a child with a blood Pb over the current Centers for Disease Control guideline of 10 ug/dL. If the blood Pb of such children remains elevated, they may be at increased risk of cognitive deficits. The blood Pb of these children should be closely monitored and appropriate steps should be taken to minimize the child's exposure to environmental lead.] /Lead, and inorganic compounds, as Pb/
TreatmentLead poisoning is usually treated with chelation therapy using DMSA, EDTA, or dimercaprol. (L21)
健康影響Lead is a neurotoxin and has been known to cause brain damage and reduced cognitive capacity, especially in children. Lead exposure can result in nephropathy, as well as blood disorders such as high blood pressure and anemia. Lead also exhibits reproductive toxicity and can results in miscarriages and reduced sperm production. (L21)
有害作用Neurotoxin - Predominantly motor
暴露経路Oral (L136)inhalation (L136)dermal (L136)
毒性の概要Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example, lead has been shown to competitively inhibit calcium's binding of calmodulin, interferring with neurotransmitter release. It exhibits similar competitive inhibition at the NMDA receptor and protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Lead also affects the nervous system by impairing regulation of dopamine synthesis and blocking evoked release of acetylcholine. However, it's main mechanism of action occurs by inhibiting delta-aminolevulinic acid dehydratase, an enzyme vital in the biosynthesis of heme, which is a necesssary cofactor of hemoglobin. (T4, A20, A22, L136)
生態毒性抜粋/AQUATIC SPECIES/ ... The effect of lead speciation on the toxicity of the metal to the shrimp Hyallela azteca in artificial test media /was investigated/. Lead was added to the medium in association with four different molarities of phosphate, 10-3, 10-4, 10-5, and 10-6 mol/litre, and at two different pH values, 6 and 8. Theoretical calculations were made of the concn of free lead in the solutions. At pH 6, very little free lead exists at high phosphate concn, irrespective of the total lead concn. Similarly, little free lead is predicted at any phosphate concn at pH 8. Mortality figures related well to the predicted values for free lead in the various solutions. At pH 6, a total lead concn of 5 mg/L, and a phosphate concn of 10-6 M/L, there was 100% mortality after 48 hr. For phosphate molarities of 10-5 and 10-4 M/L, toxicity was progressively reduced. At the highest phosphate concn, mortality only reached 25% after 120 hr. Free lead values predicted for the same three phosphate concn were 2.76, 2.24, and 0.11 mg/L, respectively.
Signs and SymptomsSymptions of chronic lead poisoning include reduced cognitive abilities, nausea, abdominal pain, irritability, insomnia, metal taste in the mouth, excess lethargy or hyperactivity, chest pain, headache and, in extreme cases, seizures, comas, and death. There are also associated gastrointestinal problems, such as constipation, diarrhea, vomiting, poor appetite, weight loss, which are common in acute poisoning. (A2, L21)
Medical SurveillancePRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/
Natural Pollution Sources... FOUND IN ... PYROMORPHITE (PHOSPHATE) ...
Human Toxicity Excerpts/SIGNS AND SYMPTOMS/ Lead phosphate can cause headache, irritability, reduced memory, and disturbed sleeping patterns. Lead enters the body by breathing and from contaminated food, beverages, or cigarettes. Lead poisoning can cause poor appetite, colic, upset stomach, headches, irritability, muscle or joint cramps and weakness./SIGNS AND SYMPTOMS/ Permanent kidney damage can result from long-term or high exposures. Lead exposure increases the risk of high blood pressure. High or repeated exposure may damage the nerves resulting in loss of coordination in the arms and legs. Can cause brain damage and anemia.
Carcinogen Classification2A, probably carcinogenic to humans. (L135)
Non-Human Toxicity Excerpts/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ A group of 270 albino rats (strain and sex unspecified) received weekly sc injections of 20 mg lead phosphate according to several dosage schedulestotal doses ranged from 40-760 mg/rat during treatment periods of up to 16 mo. Forty untreated rats served as controls. Nineteen of 29 rats that survived for 10 or more mo from the start of treatment developed renal tumorsthese rats had received total doses of 120-680 mg/rat. The tumors incl adenomas, papillomas, cystadenomas and 3 carcinomas of the renal cortex./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Lead phosphate was admin to 80 albino rats by weekly or fortnightly sc injections of 20 mg for 18 mo. Rats that survived until the end of the treatment had received a total dosage of 1.3 g. Renal adenomas developed in 29 rats, the first after 354 daysno malignant tumors were found. No renal adenomas were found in 20 untreated controls./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Lead phosphate was admin to 3 groups of 24 male Chester Beatty rats by repeated sc and subsequent ip injections according to a complex dosage schedule. No renal tumors were found in 23 rats that survived more than 200 days with a total dosage of 29 mg lead phosphate. In contrast, renal tumors were found in 14/23 surviving rats with a total dosage of 145 mg lead phosphate and in 2/3 surviving rats with a total dosage of 450 mg lead phosphate. Renal tumors incl adenomas, adenocarcinomas and one undifferentiated malignant tumor. Two renal tumors were found in 2/24 untreated control rats (1 undifferentiated malignant tumor and 1 transitional-cell carcinoma)./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Experimental studies have shown demonstrated that lead acetate, lead phosphate, and lead subacetate are carcinogenic to rat kidneys ... Rats exposed to high doses of lead in the diet developed "chronic cystic nephritis" after about 6 mo. This was followed by multiple renal tumors, either adenomas or adenocarcinomas associated with hyperplastic foci, and regenerating renal epithelium ... Renal tumors /were induced/ in mice as well as rats but not in hamsters ... The occurrence of the lead-related renal tumors in rats increased with length of exposure./OTHER TOXICITY INFORMATION/ Premature loss of teeth in rats from exptl lead poisoning is attributed to the demineralization caused by chem displacement of jawbone calcium by the colloidal secondary lead phosphate from the circulating blood.
CERCLA 報告数量Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
清浄水法要件Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Lead and compounds/
State Drinking Water Standards(AZ) ARIZONA 50 ug/L /Lead/
州飲料水ガイドライン(AZ) ARIZONA 20 ug/L /Lead/(ME) MAINE 10 ug/L /Lead/
Federal Drinking Water StandardsEPA 15 ug/L (Action Level) /Lead/