チオ硫酸ナトリウム
Sodium Thiosulfate
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基本情報
- CAS
7772-98-7- 標準SMILES
O=S([O-])([O-])=S.[Na+].[Na+]- InChIKey
AKHNMLFCWUSKQB-UHFFFAOYSA-L- 分子式
- Na2O3S2
- 平均分子量
- 158.11 g/mol
- 単同位体質量
- 157.90842442
概要
Sodium thiosulfate is an inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio. It has a role as a nephroprotective agent, an antifungal drug and an antidote to cyanide poisoning. It contains a thiosulfate(2-).
名称と識別子
- 優先名称
- Sodium Thiosulfate
- IUPAC
- disodium;dioxido-oxo-sulfanylidene-λ6-sulfane
- 現地名
- チオ硫酸ナトリウム
- 英語名
- Sodium thiosulfate
- 分子式
- Na2O3S2
- 分子量
- 158.11
名称と別名
SODIUM THIOSULFATE7772-98-7Sodium thiosulphateDisodium thiosulfateSodothiolHypoChlorine ControlChlorine CureSodium thiosulfate, anhydrousThiosulfuric acid, disodium saltSodium thiosulfate (Na2S2O3)Sodium thiosulphate (Na2S2O3)
名称をさらに表示
チオ硫酸ナトリウム [一般有機合成用]ハイポチオ硫酸ジナトリウムデトキソールチオ硫酸二ナトリウムチオ硫酸ソ-ダチオ硫酸Ｎａ0.01MOL/Lチオ硫酸ナトリウム溶液(N/100)0.025MOL/Lチオ硫酸ナトリウム溶液(N/40)0.02MOL/Lチオ硫酸ナトリウム溶液(N/50)0.05MOL/Lチオ硫酸ナトリウム溶液(N/20)0.1MOL/Lチオ硫酸ナトリウム溶液(N/10)0.2MOL/Lチオ硫酸ナトリウム溶液(N/5)0.5MOL/Lチオ硫酸ナトリウム溶液(N/2)1MOL/Lチオ硫酸ナトリウム溶液(1N)アジ化ナトリウム簡易検出キットHW 34449-10L-VOLPAC チオ硫酸ナトリウム SOLUTION VOLUMETRIC,0.05 M NA2S2O3 (0.05N)HW 35233-5L-VOLPAC チオ硫酸ナトリウム SOLUTION VOLUMETRIC,0.2 M NA2S2O3 (0.2N)HW 35245-10L-VOLPAC チオ硫酸ナトリウム SOLUTION REAG. PH. EUR.,VOLUMETRIC,0.1 M NA2S2O3 (0.1N)HW 35245-5L-VOLPAC チオ硫酸ナトリウム SOLUTION REAG. PH. EUR.,VOLUMETRIC,0.1 M NA2S2O3 (0.1N)na2s2o3ThiosulfateSODIUM HYPOSULFITENa2O3S2Sodium ThiosulfiteSodium Thiosulfat
データベース識別子
- CAS
7772-98-7- PubChem CID
- 24477
- DTXSID
DTXSID9042417- ChEMBL
CHEMBL2096650、CHEMBL3753202- ChEBI
CHEBI:132112- UNII
- L0IYT1O31N
- EC Number
- 231-867-5
- Nikkaji
- J47.986A
物性
構造計算による物性補完中
- 極性表面積
- 104 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 4
- 回転可能結合数
- 0
- 重原子数
- 7
- 形式電荷
- 0
- 複雑度
- 82.6
実験および物理化学的性質
Chemical ClassesOther Classes -> Sulfur Compounds
CosmeticsReducing
LogP-4.35 (calculated)
Density
1.667
1.7 g/cm³
Color/Form
POWDER
COLORLESS MONOCLINIC CRYSTALS
Solubility
PRACTICALLY INSOL IN ALCOHOL
50 G SOL IN 100 CC WATER; 231 G @ 100 °C
Solubility in water, g/100ml at 20 °C: 20.9
Human Drugs
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine
FDA approved drugs -> Active ingredient
Antidotes and other substances used in poisonings > Specific
Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
Decomposition
DANGEROUS; WHEN HEATED TO DECOMP, THEY EMIT HIGHLY TOXIC FUMES OF /DISODIUM OXIDE AND SULFUR OXIDES/.
300 °C
Melting Point48.5 °C
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Not Classified
Aggregated GHS information provided per 2963 reports by companies from 8 notifications to the ECHA C&L Inventory.
危険有害性情報
Regulatory Information
Chemical: Thiosulfuric acid (H2S2O3), disodium salt
Thiosulfuric acid (H2S2O3), sodium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Thiosulfuric acid (H2S2O3), sodium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 24-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14321
Sodium thiosulphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Thiosulfuric acid (H2S2O3), disodium salt: Environment tier I assessment
Fire HazardsNot combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of explosion on contact with oxidizing agents.
Hazards Summary
Potential combustible dust hazard; Decomposes slowly in water with potential generation of toxic and flammable hydrogen sulfide and corrosive hydrogen sulfite and sulfuric acid; Very soluble in water; Extremely low vapor pressure; May violently decomposes at 223 deg C; [CHEMINFO] ADI = 0-0.7 mg/kg; [JECFA] May be used in food up to 0.1%; [Hawley] See Potassium thiosulfate.
FDA Requirements121.101; LIMITATIONS: GRAS, SEQUESTRANT IN SALT UP TO 0.1%
EPA Safer ChemicalChemical: Sodium thiosulfate
化学と産業
薬理情報
ATC CodeV03AB06
Mechanism of Action
/ANTIFUNGAL ACTION OF SODIUM THIOSULFATE, USP,/...IS PROBABLY ATTRIBUTABLE TO SLOW RELEASE OF COLLOIDAL SULFUR.
IN CYANIDE POISONING, SODIUM NITRITE IS INJECTED IV...TO PRODUCE METHEMOGLOBIN WHICH COMBINES WITH...CYANIDE ION & RENDERS IT TEMPORARILY INACTIVE IN FORM OF CYANMETHEMOGLOBIN. SODIUM THIOSULFATE /USP/ IS THEN INJECTED IV TO FORM NONTOXIC THIOCYANATE.
THIOSULFATE SERVES AS SUBSTRATE FOR ENZYME RHODANESE, WHICH MEDIATES CONVERSION OF CYANIDE TO MUCH LESS TOXIC THIOCYANATE, WHICH IS EXCRETED IN URINE.
MeSH Pharmacological Classification
Agents counteracting or neutralizing the action of POISONS.
Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.
Drugs used in the treatment of tuberculosis. They are divided into two main classes: first-line agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and second-line drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
Absorption, Distribution and ExcretionPOORLY ABSORBED FROM BOWEL. ... THIOSULFATE ION DISTRIBUTES ITSELF IN EXTRACELLULAR FLUID.
用途と製造
Uses
It is added in small quantities to ammonium thiosulfate, which is used as a photographic fixing salt. The hydrated salt is used as an anti-chlorine in bleaching, in wastewater purification, for reduction of dichromate in chromed leather production, and as a solvent for silver chloride in the chloride roasting of silver-containing minerals. [Ullmann] Used in paper bleaching, photography (fixer), silver extraction, dyeing textiles (mordant), and leather manufacturing; Also used as an antidote for cyanide poisoning and in vet medicine for bloat and ringworm; [Merck Index]
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