りん酸/亜鉛,(1:x)

Zinc Phosphate

HCID 24519CAS 13847-22-8

基本情報

標準SMILES: O=P([O-])([O-])[O-].O=P([O-])([O-])[O-].[Zn+2].[Zn+2].[Zn+2]
InChIKey: LRXTYHSAJDENHV-UHFFFAOYSA-H
分子式: Zn3-(P-O4)2
平均分子量: 386.1 g/mol
単同位体質量: 381.69426682

概要

The CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Phosphate...

名称と識別子

優先名称: Zinc Phosphate
IUPAC: trizinc diphosphate
現地名: りん酸/亜鉛,(1:x)
英語名: phosphoric acid, zinc salt
分子式: H3O4P.xZn
分子量: 0

名称と別名

Zinc Phosphate7779-90-0Trizinc diphosphateZinc orthophosphateDelaphosTrizinc phosphateTribasic zinc phosphateDelaphos 2MBonderite 40Granodine 80Microphos 90Granodine 16NC

名称をさらに表示

りん酸/亜鉛,(1:x)Einecs 237-583-8Phosphoric acid/zinc,(1:x) salt

Bonderite 181Bonderite 880Zinc acid phosphateHeucophos ZP 10Phosphinox PZ 06Sicor ZNP/MSicor ZNP/SVirchem 931

データベース識別子

CAS: 13847-22-8、14332-60-6、7779-90-0
PubChem CID: 24519
DTXSID: DTXSID3064807
ChEMBL: CHEMBL2286756
UNII: 1E2MCT2M62
EC Number: 231-944-3、237-583-8

物性

構造計算による物性

極性表面積: 173 Å²
水素結合供与体数: 0
水素結合受容体数: 8
回転可能結合数: 0
重原子数: 13
形式電荷: 0
複雑度: 36.8

実験および物理化学的性質

Chemical Classes · 2 件

Metals -> Phosphates, Metallic Salts

Metals -> Metals, Inorganic Compounds

CosmeticsCosmetic ingredients (Zinc Phosphate) -> CIR (Cosmetic Ingredient Review)

Density4 @25 °C

Melting Point900 °C

Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Physical Description · 2 件

Liquid; Other Solid; Dry Powder; Liquid; Liquid; CBI; Wet Solid; Dry Powder

White solid; [Hawley] White odorless powder; [MSDSonline]

物理化学的性質

EPAの化学物質情報: Phosphoric acid, zinc salt (13847-22-8)

安全と法規制

GHS分類

GHS Classification · 6 件

Warning

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P273, P391, and P501 (click each P-code to see the statement)

Warning

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P273, P391, and P501 (click each P-code to see the statement)

危険有害性情報

Regulatory Information · 5 件

Chemical: Phosphoric acid, zinc salt (2:3)

Chemical: Phosphoric acid, zinc salt

Phosphoric acid, zinc salt (2:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphoric acid, zinc salt (2:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 31-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14696

Phosphoric acid, zinc salt: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Phosphoric acid, zinc salt (2:3): Human health tier I assessment

Hazards Summary · 2 件

Powder may cause eye irritation; [MSDSonline] Oral LD50 (rat) >5000 mg/kg; [Ullmann] See Zinc.

See Zinc.

Hazard Classes and Categories · 6 件

Not Classified

Aquatic Acute 1 (100%)

Hazardous to the aquatic environment (acute) - category 1

Hazardous to the aquatic environment (Acute) - Category 1

Reproductive toxicity - Category 2

Aquatic Acute 1

安全と保護具

Exposure Control and Personal Protection · 2 件

0.1 [mg/m3] (respirable fraction), 2 mg/m3 (inhalable fraction)-for Zn inorg. compds[German Research Foundation (DFG)]

0.1 [mg/m3] (respirable fraction), 2 mg/m3 (inhalable fraction) for Zn inorg. cmpnds[German Research Foundation (DFG)]

Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (L134) Chronic Oral: 0.3 mg/kg/day (L134)

Protective Action Criteria (PAC) · 3 件

1.8 [mg/m3]

20 [mg/m3]

120 [mg/m3]

毒性情報

TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)

Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)

Exposure RoutesInhalation (L49) ; oral (L49) ; dermal (L49)

Toxicity Summary · 3 件

Safe for use in cosmetics, with qualifications

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Signs and Symptoms · 1 件

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

安全データ

tsca: TSCA listed

化学と産業

薬理情報

Metabolism/Metabolites · 1 件

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)

用途と製造

Uses · 4 件

CIR ingredient: Zinc Phosphate

Used in dental cements, phosphors, and coatings of steel and aluminum; [Hawley] The most important phosphate-containing pigment--reacts with iron to produce a protective film; [Ullmann]

Aluminum Producing [Category: Industry]

Zinc phosphate is used as a dental cement and corrosion resistant coating. (L74)

U.S. Production2023: 8,500,000 - <10,000,000 lb

Consumer UsesCorrosion inhibitor

Industry UsesStabilizing agent

Household ProductsInformation on 11 consumer products that contain Zinc phosphate in the following categories is provided:

General Manufacturing Information · 3 件

Miscellaneous Manufacturing

Phosphoric acid, zinc salt (2:3): ACTIVE

Phosphoric acid, zinc salt (1:?): ACTIVE