フッ化窒素

Excerpt from ERG Guide 122 [Gases - Oxidizing (Including Refrigerated Liquids)]:

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water.

Fresh air, rest.

Remove contaminated clothes.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

Excerpt from NIOSH Pocket Guide for Nitrogen trifluoride:

General First Aid:

(General first aid procedures)

Heating will cause rise in pressure with risk of bursting.

Poisonous gases, including fluorine, are produced in fire.

· Wear positive pressure self-contained breathing apparatus (SCBA).

Biological Exposure Indices (BEI) [ACGIH] - Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Do not extinguish the fire unless the flow of gas can be stopped and any remaining gas is out of the line. Specially trained personnel may use fog lines to cool exposures and let the fire burn itself out. Vapors are heavier than air and will collect in low areas. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminates waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure location. ... The only respirators recommended for firefighting are self-contained breathing apparatuses that have full face-pieces and are operated in a pressure-demand or other positive-pressure mode.

If material on fire or involved in fire: Solid streams of water may be ineffective. Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.) Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

Turn leaking cylinder with the leak up to prevent escape of gas in liquid state.

Store separately in an area isolated from flammables, combustibles, or other yellow coded materials. ... High concentrations cause a deficiency of oxygen with the risk of unconsciousness or death. Check that oxygen content is at least 19% before entering storage or spill area.

If in a building, evacuate building and confine vapors by closing doors and shutting down HVAC systems. Restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak to disperse the gas. Wear chemical protective suit with self-contained breathing apparatus to combat spills. Stay upwind and use water spray to "knock down" vapor; contain runoff. Stop the flow of gas, if it can be done safely from a distance. If source is a cylinder and the leak cannot be stopped in place, remove the leaking cylinder to a safe place, and repair leak or allow cylinder to empty. Keep this chemical out of confined spaces, such as a sewer, because of the possibility of explosion, unless the sewer is designed to prevent the buildup of explosive concentrations.

Persons not wearing protective equipment and clothing should be restricted from areas of leaks until cleanup has been completed. ... 1. Ventilate area of leak to disperse gas. 2. Stop flow of gas. If source of leak is a cylinder and the leak cannot be stopped in place, remove the leaking cylinder to a safe place in the open air, and repair the leak or allow the cylinder to empty.

Gas leakage: Pass through a reducing agent (sodium bisulfite) and sodium bicarbonate solution with a trap in the line, when the valve can not be closed.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Spillage Disposal: Ventilation. NEVER direct water jet on liquid. Personal protection: self-contained breathing apparatus.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

The substance can be absorbed into the body by inhalation.

inhalation

IDENTIFICATION AND USE: Nitrogen trifluoride is a colorless gas with a moldy odor. It is used as a chamber-cleaning gas in the manufacture of electronics. Nitrogen trifluoride is preferred to F2 in high-power chemical lasers because of its ease of handling at ambient temperatures. It is also an oxidizer for high-energy fuels, chemical synthesis. HUMAN EXPOSURE AND TOXICITY: Nitrogen trifluoride is a simple asphyxiant. Five volunteers were exposed to nitrogen trifluoride at concentrations of 100 and 500 ppm for 2 to 3 minutes. No odor was detected at 100 ppm, but one of the five reported the odor detectable at 500 ppm. ANIMAL STUDIES: Nitrogen trifluoride has a moderate acute inhalation toxicity causing anoxic deaths due to methemoglobinemia. Acute inhalation also results in slight histologic changes in the liver and kidneys of some rats and enlargement and darkening of the spleen. Serum glutamic-oxaloacetic transaminase levels in the rats were essentially unaffected after acute inhalation. Dogs surviving exposure at 9600 ppm for 60 minutes exhibited Heinz body-included hemolysis, anemia, decreased hematocrit, decreased hemoglobin, reduced red blood cell count, and clinical signs consistent with histotoxic anoxia as a result of methemoglobin formation. Rabbits that received 9 intraperitoneal injections of 10 mL of nitrogen trifluoride gas in 29 days showed enlarged spleens, pathologic changes in the liver, and myocardial degeneration.

The following medical procedures should be made available to each employee who is exposed to nitrogen trifluoride at potentially hazardous levels: A complete history and physical examination /should be performed/ to detect pre-existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Examination of the blood, cardiovascular system, nervous system, liver, and kidneys should be stressed; ... a complete blood count should be performed including a red cell count, a white cell count, a differential count of a stained smear, as well as hemoglobin and hematocrit. ... The aforementioned medical examinations should be repeated on an annual basis. Methemoglobin determinations should be performed if overexposure is suspected or signs and symptoms of toxicity occur.

Nitrogen trifluouride's production and use in high energy fuels and as a chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

Unlike many other greenhouse gases, fluorinated gases /such as nitrogen trifluoride/ have no natural sources and only come from human-related activities. They are emitted through a variety of industrial processes such as aluminum and semiconductor manufacturing. ... Like other long-lived greenhouse gases, fluorinated gases are well-mixed in the atmosphere, spreading around the world after they're emitted. Fluorinated gases are removed from the atmosphere only when they are destroyed by sunlight in the far upper atmosphere. In general, fluorinated gases are the most potent and longest lasting type of greenhouse gases emitted by human activities(1).

/LABORATORY ANIMALS: Acute Exposure/ Rats that had received single intraperitoneal injections of nitrogen trifluoride gas (8-15 mL/kg) became cyanotic and developed enlarged spleens, possibly as a secondary response to the methemoglobinemia.

/LABORATORY ANIMALS: Acute Exposure/ Nitrogen trifluoride has a moderate acute inhalation toxicity causing anoxic deaths due to methemoglobinemia. Acute inhalation also results in slight histologic changes in the liver and kidneys of some rats and enlargement and darkening of the spleen. Serum glutamic-oxaloacetic transaminase levels in the rats were essentially unaffected after acute inhalation.

/LABORATORY ANIMALS: Acute Exposure/ When rats inhaled 1000 ppm nitrogen trifluoride for 4 hours, a substantial increase in circulating methemoglobin was detectable; however, inhalation of 3000 ppm for 10 minutes failed to show such an effect. When rats inhaled 2500 ppm nitrogen trifluoride for 4 hours, deaths were commonplace. Eighty-seven percent of the rats died after inhalation of 10,000 ppm nitrogen trifluoride for 60 to 70 minutes; the methemoglobin concentrations at the time of death were equivalent to 60% to 70% of the total blood pigment.

/LABORATORY ANIMALS: Acute Exposure/ Dogs surviving exposure at 9600 ppm for 60 minutes exhibited Heinz body-induced hemolysis, anemia, decreased hematocrit, decreased hemoglobin, reduced red blood cell count, and clinical signs consistent with histotoxic anoxia as a result of methemoglobin formation.

For more Non-Human Toxicity Excerpts (Complete) data for NITROGEN TRIFLUORIDE (8 total), please visit the HSDB record page.

According to the 2012 TSCA Inventory Update Reporting data, 3 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of nitrogen trifluoride in the United States may be as low as <10 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,096 workers (140 of these are female) were potentially exposed to nitrogen trifluoride in the US(1). Occupational exposure to nitrogen trifluoride may occur through inhalation and dermal contact with this compound at workplaces where nitrogen trifluoride is produced or used. (SRC)