化工社化工社 化学情報印刷レポート · 研究参考用
ホスホリルトリブロミド
トリブロモホスフィンオキシド · オキシ臭化りん · ホスホリルブロミド · ホスホリルトリブロミド · りん酸トリブロミド · 臭化ホスホリル · オキシ臭化りん(V) · リン酸オキシブロミド
識別子と物理属性
| CAS No. | 7789-59-5 |
|---|---|
| 分子式 | Br3OP |
| 平均分子量 | 286.69 g/mol |
| 単同位体質量 | 283.72368755 g/mol |
| SMILES | O=P(Br)(Br)Br |
| InChIKey | UXCDUFKZSUBXGM-UHFFFAOYSA-N |
| PubChem CID | 24613 |
| EC No. | 232-177-7 |
| DTXSID | DTXSID2064868 |
| 現地名 | ホスホリルトリブロミド |
化学・物理的性質
| XLogP | 2.2 |
|---|---|
| 極性表面積 | 17.1 |
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 1 |
| 回転可能結合数 | 0 |
| 重原子数 | 5 |
| 形式電荷 | 0 |
| 複雑度 | 53 |
| 物質分類 | Other Classes -> Halogens, Inorganic CompoundsCorrosives |
| SpringerMaterials Properties | Gibbs energy |
| 密度 | greater than 1 (NOAA, 2007)2.8222.82 g/mL at 25 °C(lit.) |
| Color/Form | COLORLESS CRYSTALSTHIN PLATES, FAINT ORANGE TINT |
| 溶解度 | SOL IN ETHER, BENZENE, CHLOROFORM, CARBON DISULFIDE, CONCENTRATED SULFURIC ACIDreacts with H2Osoluble in benzene, ethyl ether,chloroform分解する |
| 沸点 | AT 758 MM HG IT BOILS AT 193 °C WITH DECOMPOSITION192 °C(lit.) |
| Decomposition | WHEN HEATED TO DECOMP, IT EMITS HIGHLY TOXIC FUMES OF BROMIDES & PO(X). |
| 融点 | 133 °F (NOAA, 2007)56 °C (IN HOT WATER)56 °C(lit.) |
| Physical Description | Phosphorus oxybromide appears as a colorless crystalline solid or liquid if heated above 133 °F with a pungent odor. It is commonly heated and shipped in a molten state. Soluble in water, but, decomposed by water to hydrobromic and phosphoric acid with evolution of heat. Reacts with organic materials to cause fire. Evolves highly toxic and corrosive gases when exposed to fire. Corrosive to metals and tissue. Used to make other chemicals.Colorless solid[Hawley] Light brown solid[MSDSonline] |
| Other Experimental Properties | SLOWLY HYDROLYZES IN WATER FORMING PHOSPHORIC ACID & HYDROGEN BROMIDEAT 758 MM HG IT BOILS AT 193 °C WITH DECOMPOSITIONDECOMPOSES IN COLD WATER |
| 引火点 | 189°C |
| 貯蔵条件 | Store below +30°C. |
| 外観・状態 | 塊 |
| 比重 | 2.822 |
| 色 | 白から黄色 |
| 比熱容量 | Cp(gas): 0.31 J/(g·K), at 25℃ |
| Merck | 14,7348 |
| InChI | 1S/Br3OP/c1-5(2,3)4 |
| InChIKey | UXCDUFKZSUBXGM-UHFFFAOYSA-N |
| SMILES | BrP(Br)(Br)=O |
| CAS データベース | 7789-59-5(CAS DataBase Reference) |
| NISTの化学物質情報 | Phosphorus tribromide oxide(7789-59-5) |
| EPAの化学物質情報 | Phosphoric tribromide (7789-59-5) |
化学的特性
colorless to grey-brown crystals or fused mass
安全性と法規制
| GHS 分類 | DangerH290 (13%): May be corrosive to metals [Warning Corrosive to Metals]P234, P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P363, P390, P403+P233, P405, P406, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 69 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 規制情報 | Chemical: Phosphoryl bromideStatus: Active Update: 31-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/24309Phosphoryl bromide: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 輸送ラベル（DOT） | Corrosive |
| 火災危険 | Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]:· EXCEPT FOR ACETIC ANHYDRIDE (UN1715), THAT IS FLAMMABLE, some of these materials may burn, but none ignite readily. |
| 健康有害性 | Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]:· CORROSIVE and/or TOXICinhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. |
| 有害性の概要 | Highly reactive with organic materialsA strong skin and tissue irritant[Hawley] May cause fire on contact with organic substancesCorrosive to tissue[CAMEO] Corrosive to skin and eyes[eChemPortal: ERMA] Reacts violently with waterA corrosive substance that can cause injury to the skin, eyes, and respiratory tractInhalation may cause chemical pneumonitis[MSDSonline] |
| 輸送番号・ガイド（DOT） | 1939 1372576 137 |
| 反応性グループ | Acyl Halides, Sulfonyl Halides, and Chloroformates |
| Reactivity Alerts | Water-Reactive |
| Reactivity Profile | PHOSPHORUS OXYBROMIDE is incompatible with water, strong oxidizing agents, alcohols, bases, including amines. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. |
| DOT Emergency Guidelines | /GUIDE 137: SUBSTANCES - WATER-REACTIVE - CORROSIVE/ Health: CORROSIVE and/or TOXICinhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns, or death. Fire will produce irritating, corrosive and/or toxic gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control or dilution water may cause pollution. /Phosphorus oxybromidePhosphorus oxybromide, moltenPhosphorus oxybromide, solid//GUIDE 137: SUBSTANCES - WATER-REACTIVE - CORROSIVE/ Fire or Explosion: ... Some of these materials may burn, but none ignite readily. May ignite combustibles (wood, paper, oil, clothing, etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases. Flammable/toxic gases may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. Substance may be transported in a molten form. /Phosphorus oxybromide/GUIDE 137: SUBSTANCES - WATER-REACTIVE - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75) feet for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Phosphorus oxybromide/GUIDE 137: SUBSTANCES - WATER-REACTIVE - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLYit is not effective in spill situations where direct contact with the substance is possible. /Phosphorus oxybromideFor more DOT Emergency Guidelines (Complete) data for PHOSPHORUS OXYBROMIDE (8 total), please visit the HSDB record page. |
| DOT Hazard Classification | Phosphorus oxybromideUN1939Class 8 Corrosive material (49 eCFR § 173.136)PG II: the degree of danger presented by the material is mediumPhosphorus oxybromide, moltenUN2576 |
| Air and Water Reactions | Reacts slowly and exothermically with water to form phosphoric acid and hydrobromic acid [Merck, 11th ed. 1989]. Decomposes exothermically in water to form toxic fumes of hydrobromic and phosphoric acids [Lewis]. |
| 消火 | Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]: |
| 漏出応急措置 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. |
| 応急処置 | Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]:General First Aid: |
| 暴露管理・個人防護 | · Wear positive pressure self-contained breathing apparatus (SCBA). |
| 保管条件 | ...SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, &...PERIODICALLY INSPECTED & MONITORED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED...STORE IN SEALED GLASS AMPULES. |
| 非火災時の漏出対応 | Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]: |
| Preventive Measures | THE BASIC VENTILATION METHODS ARE LOCAL EXHAUST AND DILUTION OR GENERAL VENTILATION. |
| Isolation and Evacuation | Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]:Immediate precautionary measure |
| Personal Protective Equipment (PPE) | Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]: |
| Emergency Response Planning Guidelines | · When material is not involved in fire, do not use water on material itself. |
| 有害作用 | Dermatotoxin - Skin burns. |
| Human Toxicity Excerpts | SYMPTOMATOLOGY (...INGESTION OR SKIN CONTACT): 1. CORROSION OF MUCOUS MEMBRANES OF MOUTH, THROAT...ESOPHAGUS, WITH...PAIN & DYSPHAGIA. NECROTIC AREAS...GRAYISH WHITE BUT SOON...BLACKISH DISCOLORATION (YELLOW IN CASE OF NITRIC ACID) & SOMETIMES SHRUNK OR WRINKLED TEXTURE. 2. EPIGASTRIC PAIN...MAY BE ASSOC WITH NAUSEA & VOMITING...INTENSE THIRST. 3. CIRCULATORY COLLAPSE...CLAMMY SKIN, WEAK & RAPID PULSE, SHALLOW RESP...SCANTY URINE. ...SHOCK IS OFTEN...CAUSE OF DEATH. 4. ASPHYXIAL DEATH DUE TO GLOTTIC EDEMA. /ACIDS/SYMPTOMATOLOGY.../INGESTION/: 5. ULCERATION OF ALL MEMBRANES & TISSUES WITH WHICH ACID COMES IN CONTACT. ULCERATED AREAS OFTEN PERFORATE, LEADING TO MEDIASTINITIS & PERITONITIS. 6. LATE ESOPHAGEAL, GASTRIC & PYLORIC STRUCTURES & STENOSIS...MAY REQUIRE...SURGICAL REPAIR, SHOULD BE ANTICIPATED. PERMANENT SCARS MAY...APPEAR IN CORNEA, SKIN & OROPHARYNX. 7. UNCORRECTED CIRCULATORY COLLAPSE OF SEVERAL HR...MAY LEAD TO RENAL FAILURE & ISCHEMIC LESIONS IN LIVER & HEART. /ACIDS/ |
| F | 10-21 |
| 水環境危害等級（WGK） | 3 |
| TSCA 収載状態 | TSCA listed |
| 輸送番号（UN） | UN 2576 8/PG II (PHOSPHORUS OXYBROMIDE, MOLTEN) |
| 税関コード | 28129090 |
| 危険文句（R） | 14-34-37 |
| 危険表示 | C |
| hazard_note | Corrosive |
| 安全措置（S） | 26-36/37/39-43-45-7/8-Neverusewater. |
| 危険等級 | 8Eye Dam. 1Skin Corr. 1B |
| 包装等級 | II |
| 貯蔵分類 | 8A - Combustible corrosive hazardous materials |
| 有害物質データ | 7789-59-5(Hazardous Substances Data) |
用途
使用
Phosphorus(V) Oxybromide is a reagent used in the preparation of phosphoryl halide for N-protection of amino acids using group assisted purification (GAP). Phosphorus(V) Oxybromide is a brominating agent.
一般的な説明
A colorless crystalline solid or liquid if heated above 133° F with a pungent odor. Phosphorus oxybromide is commonly heated and shipped in a molten state. Soluble in water, but, decomposed by water to hydrobromic and phosphoric acid with evolution of heat. Reacts with organic materials to cause fire. Evolves highly toxic and corrosive gases when exposed to fire. Corrosive to metals and tissue. Used to make other chemicals.