2-ヒドロキシエチル=ステアラート
Glycol monostearate
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基本情報
- CAS
111-60-4- 標準SMILES
CCCCCCCCCCCCCCCCCC(=O)OCCO- InChIKey
RFVNOJDQRGSOEL-UHFFFAOYSA-N- 分子式
- C20H40O3
- 平均分子量
- 328.5 g/mol
- 単同位体質量
- 328.29774513
概要
Polyoxyl 40 stearate is an octadecanoate ester composed of repeating 8-40 ethyleneoxy units. It is an ingredient used in cosmetics and beauty products primarily as a surfactant and emulsifier. It has a role as a nonionic surfactant, an emulsifier and a food emulsifier. It is a hydroxypolyether and an octadecanoate ester.
名称と識別子
- 優先名称
- Glycol monostearate
- IUPAC
- 2-hydroxyethyl octadecanoate
- 現地名
- 2-ヒドロキシエチル=ステアラート
- 英語名
- ETHYLENE GLYCOL MONOSTEARATE
- 分子式
- C20H40O3
- 分子量
- 328.53
名称と別名
Ethylene glycol monostearateGlycol stearate111-60-42-Hydroxyethyl octadecanoateMonthybaseParastarinMonthyleSedetolIvoritGlycol monostearateProdhybase ethylProdhybas N
名称をさらに表示
セラシントMNパラスタリングリコールステアラートグリコールモノステアラートプロジバスNセデトールエンピラン2848モンチルモンチベースエチレングリコールステアラートエチレングリコールオクタデカノアートオクタデカン酸2-ヒドロキシエチルイボリットエチレングリコールモノステアラート2-ヒドロキシエチル=ステアラートセラシントMステアリン酸2-ヒドロキシエチルプロジベースエチルエメレスト2350テゴステアラートs151FGMSS 151lipoegms
Clindrol SEGEmerest 2350Ethylene glycol stearateLipo EGMSEmpilan 2848OCTADECANOIC ACID, 2-HYDROXYETHYL ESTERUSAF KE-11STEARIC ACID, 2-HYDROXYETHYL ESTER
データベース識別子
- CAS
111-60-4、86418-55-5、9004-99-3- PubChem CID
- 24762
- DTXSID
DTXSID5026881- ChEMBL
CHEMBL2355383- ChEBI
CHEBI:32027- UNII
- 0324G66D0E
- EC Number
- 203-886-9、617-851-4、618-405-1、926-608-4
- Nikkaji
- J110.879D
物性
構造計算による物性補完中
- XLogP
- 7.8
- 極性表面積
- 46.5 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 3
- 回転可能結合数
- 19
- 重原子数
- 23
- 形式電荷
- 0
- 複雑度
- 241
実験および物理化学的性質
PolymersOther Classes -> Polyoxyethylenes
Cosmetics
Cosmetic ingredients (Glycol Stearate) -> CIR (Cosmetic Ingredient Review)
Cosmetic ingredients (Glycol Stearate SE) -> CIR (Cosmetic Ingredient Review)
Surfactant; Opacifying; Emollient; Emulsifying; Humectant
OdorFAINT FATTY ODOR
TasteSLIGHTLY BITTER, FATTY TASTE
Color/FormCREAM-COLORED SOFT, WAXY OR PASTY SOLID @ 25 °C
Solubility
POLYETHYLENE GLYCOL ESTERS AND ETHERS INCR THE WATER SOLUBILITY OF TYROTHRICIN.
SOL IN CARBON TETRACHLORIDE, PETROLEUM BENZIN, CHLOROFORM, ETHER; SLIGHTLY SOL IN ALCOHOL; INSOL IN WATER /POLYETHYLENE GLYCOL 400 MONOSTEARATE USP XVI/
GENERALLY SOL OR DISPERSIBLE IN WATER
SOL IN TOLUENE, ACETONE, ETHER AND ETHANOL
Flash PointMYRJ 45: 500 °F OC
Melting Point
MP: 30-34 °C /POLYETHYLENE GLYCOL 400 MONOSTEARATE USP XVI/
60.00 to 61.00 °C. @ 760.00 mm Hg
Physical Description
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 75.2% (357 of 475) of all reports.
Warning
H315 (18.9%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 475 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
This chemical does not meet GHS hazard criteria for 87% (267 of 307) of all reports.
危険有害性情報
Regulatory Information
Chemical: Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy-
Chemical: Octadecanoic acid, 2-hydroxyethyl ester
Octadecanoic acid, 2-hydroxyethyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Octadecanoic acid, 2-hydroxyethyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
FRI - indicates a polymeric substance containing no free-radical initiator in its Inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used.
Octadecanoic acid, 2-hydroxyethyl ester: Does not have an individual approval but may be used under an appropriate group standard
Tegin G: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Caused bladder stones in rats when fed at >20% of diet; [JECFA] Mild irritant effect in eye of rabbit; [RTECS] Hydrolyzed in the intestines--fatty acids metabolized and the polyoxyethylene residues excreted unchanged in the urine; [HSDB] An irritant; [MSDSonline] See STEARATES.
EPA Safer Chemical
化学と産業
薬理情報
Absorption, Distribution and Excretion
THESE ESTERS ARE HYDROLYZED IN THE BOWEL. THE FATTY ACID IS ABSORBED & METABOLIZED; AT LEAST THE SHORTER POLYOXYETHYLENE RESIDUES ARE ALSO ABSORBED, BUT THEY ARE EXCRETED UNCHANGED IN THE URINE (NO DETECTABLE METABOLISM TO OXALIC ACID IN MAN).
Cellular LocationsExtracellular
用途と製造
Uses
CIR ingredient: Glycol Stearate
CIR ingredient: Glycol Stearate SE
Used as a surfactant, emulsifier (cosmetics, pharmaceuticals, textile finishes, defoamers, and baked goods), dye assistant, lubricant, and antistatic agent; Also used in dentifrice compositions and to make creams, lotions, ointments, and pharmaceutical preparations; [HSDB]
Textiles (Printing, Dyeing, or Finishing) [Category: Industry]
SURFACTANT
PEG 400 MONOSTEARATE USP XVI: IN PREPN OF CREAMS, LOTIONS, OINTMENTS & PHARMACEUTICAL PREPN WHICH ARE SOL IN WATER
U.S. Production
2023: 1,000,000 - <2,500,000 lb
(1972) 2.4X10+9 GRAMS (MONOSTEARATE)
(1975) 3.13X10+9 GRAMS (MONOSTEARATES)
(1984) 2.91X10+9 g
Consumer UsesSurfactant (surface active agent)
Industry UsesSurfactant (surface active agent)
Methods of ManufacturingREACTION OF ETHYLENE OXIDE WITH STEARIC ACID
Formulations/PreparationsPOLYOXYETHYLENE (8) STEARATE: MIXTURE OF MONO- & DIESTERS OF STEARIC ACID & MIXED POLYOXYETHYLENE DIOLS HAVING AN AVG POLYMER LENGTH OF 7.5 OXYETHYLENE UNITS.
Household Products
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