| GHS 分類 | DangerH270 (99.6%): May cause or intensify fireoxidizer [Danger Oxidizing gases]P203, P220, P244, P260, P261, P264, P264+P265, P270, P271, P273, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P318, P319, P320, P321, P332+P317, P337+P317, P362+P364, P363, P370+P376, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 262 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H270: May cause or intensify fire |
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| 規制情報 | Hazard Traits - Ocular ToxicityRespiratory ToxicityOzone is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ozone are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 14-12-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/22480Ozone: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| 輸送ラベル（DOT） | Poison Gas |
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| 火災危険 | Severe explosion hazard when shocked, exposed to heat or flame, or by chemical reaction with organic substances, especially reducing agents. Ozone is a powerful oxidizing agent. Incompatible with alkenesaromatic compoundsbenzene, rubberbrominedicyanogendiethyl etherdinitrogen tetroxidehydrogen bromide4-hydroxy-4-methyl-1,6-heptadienenitrogen trichloridestibinetetrafluorohydrazine. Avoid contact with organic materials. (EPA, 1998)Not combustible but enhances combustion of other substances. Many reactions may cause fire or explosion. Risk of fire and explosion on contact with combustible substances. |
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| 火災の可能性 | POWERFUL OXIDIZING AGENT ... EVOLVES MORE HEAT AND USUALLY STARTS AT A LOWER TEMPERATURE THAN OXIDATION WITH BIATOMIC OXYGEN.Dangerous fire ... risk in contact with organic materials. |
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| 健康有害性 | Ozone is highly toxic via inhalation or by contact of liquid to skin, eyes, or mucous membranes. It is capable of causing acute to chronic lung damage, burns, and death or permanent injury. Ozone can be toxic at a concentration of 100 ppm for 1 minute. Ozone is capable of causing death from pulmonary edema. It increases sensitivity of the lungs to bronchoconstrictors and allergens, increases susceptibility to and severity of lung bacterial and viral infections. (EPA, 1998) |
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| 有害性の概要 | Like phosgene and nitrogen dioxide, ozone is classified as less soluble relative to more soluble irritant inhalants like ammonia and chlorine. The less soluble vapors are more likely to cause potentially fatal pulmonary edema without the signs of severe upper respiratory injury. (See Comments for phosgene.) [LaDou, p. 564] Ozone is fibrogenic to the lungs in the context of an acute inhalation exposure complicated by bronchiolitis obliterans. |
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| 反応性グループ | Oxidizing Agents, Strong |
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| Special Reports | MENZEL DBMETABOLIC EFFECTS OF OZONE EXPOSUREADV MOD ENVIRON TOXICOL 5(INT SYMP BIOMED EFFECTS OZONE RELAT PHOTOCHEM OXIDN) 47 (1983). A REVIEW WITH 15 REFERENCES ON METABOLIC EFFECTS OF OZONE EXPOSURE.CHOW CKINFLUENCE OF DIETARY VITAMIN E ON SUSCEPTIBILITY TO OZONE EXPOSUREADV MOD ENVIRON TOXICOL 5(INT SYMP BIOMED EFFECTS OZONE RELAT PHOTOCHEM OXIDN) 75 (1983). A REVIEW WITH 50 REFERENCES ON THE INFLUENCE OF VITAMIN E ON THE TOXICITY OF OZONE.FOLINSBEE LJEFFECTS OF OZONE EXPOSURE ON LUNG FUNCTION IN MAN: A REVIEWREV ENVIRON HEALTH 3 (3): 211 (1981). A REVIEW ON THE EFFECTS OF OZONE ON HUMAN LUNG FUNCTION ARE DISCUSSED WITH PARTICULAR ATTENTION TO LEVELS WHICH ARE NEAR THE THRESHOLD OF PRODUCING NO EFFECT.Antioxidant Vitamins and Prevention of Lung Disease. Ann N Y Acad Sci669: 141-55 (1992).For more Special Reports (Complete) data for OZONE (8 total), please visit the HSDB record page. |
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| Reactivity Alerts | Strong Oxidizing Agent |
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| OSHA Standards | Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 0.1 ppm (0.2 mg/cu m).Vacated 1989 OSHA PEL TWA 0.1 ppm (0.2 mg/cu m)STEL 0.3 ppm (0.6 mg/cu m) is still enforced in some states. |
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| Reactivity Profile | OZONE is a propellantignites upon contact with alcohols, amines, ammonia, beryllium alkyls, boranes, dicyanogen, hydrazines, hydrocarbons, hydrogen, nitroalkanes, powdered metals, silanes, or thiols [Bretherick 1979. p.174]. Aniline in a atmosphere of ozone produces a white galatinous explosive ozobenzene [Mellor 1:911. 1946-47]. A mixture of ether and ozone forms aldehyde and acetic acid and a heavy liquid, ethyl peroxide, an explosive [Mellor 1:911. 1946-47]. Severe explosions occur attempting to form tribromic octaoxide from bromine and ozone [Mellor 2, Supp. 1:748. 1956]. Mixtures of ozone and dinitrogen pentaoxide are flammable or explosive [Mellor 8, Supp. 2:276. 1967]. Ozone and ethylene react explosively [Berichte 38:3837]. Nitrogen dioxide and ozone react with the evolution of light, and often explode [J. Chem. Phys. 18:366 1920]. Contact of very cold liquefied gas with water may result in vigorous or violent boiling of the product and extremely rapid vaporization due to the large temperature differences involved. If the water is hot, there is the possibility that a liquid "superheat" explosion may occur. Pressures may build to dangerous levels if liquid gas contacts water in a closed container, [Handling Chemicals Safely 1980]. |
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| Chemical Dangers | Decomposes on warming. This produces oxygen. This generates fire and explosion hazard. Reacts violently with inorganic and organic compounds. This generates fire and explosion hazard. Attacks rubber. |
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| 消火 | In case of fire: keep cylinder cool by spraying water. (EPA, 1998)In case of fire in the surroundings, use appropriate extinguishing media. Combat fire from a sheltered position. |
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| 応急処置措置 | Fresh air, rest. Half-upright position. Refer for medical attention.ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. |
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| 応急処置 | Warning: Effects may be delayed for 12 to 24 hours. Caution is advised.(General first aid procedures) |
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| 安全保管 | Fireproof if in building. Separated from all substances. Cool. |
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| 保管条件 | CYLINDERS OF DISSOLVED OZONE SHOULD BE STORED IN REFRIGERATED AREAS & AWAY FROM ALL REDUCING AGENTS, FLAMMABLE MATERIALS & SUBSTANCES SUCH AS IRON, COPPER OR CHROMIUM THAT MAY CATALYZE DECOMP.Store in well-ventilated, cool, dark places. Detached storage is preferred. Avoid storage near combustible materials. |
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| 非火災時の漏出対応 | Isolate area and deny entry. Stay upwindkeep out of low areas. Ventilate closed spaces before entering them. Workers handling liquid ozone should wear protective equipment designed for exposure to cryogenic liquid. (EPA, 1998) |
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| 処分方法 | Evaporation: Provide ventilation to dilute and disperse small amt of ozone into the outside atmosphere.In the fume hood, wastes to be slowly released to air. |
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| 漏出処分 | Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. |
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| Preventive Measures | PROCESSES EMPLOYING OZONE SHOULD BE TOTALLY ENCLOSED OR SO EQUIPPED WITH EXHAUST VENTILATION. ... ALL ELECTRICAL EQUIPMENT SHOULD BE SUITABLY INSULATED.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
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| Isolation and Evacuation | Excerpt from ERG Guide 123 [Gases - Toxic]: |
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| Eye Prevention | Wear face shield or eye protection in combination with breathing protection. |
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| Fire Prevention | NO open flames, NO sparks and NO smoking. NO contact with combustible substances. Closed system, ventilation, explosion-proof electrical equipment and lighting. |
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| Treatment | EYES: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.
INHALATION: Move person to fresh air. If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably by mouth-to-mouth if possible. Call a poison control center or doctor for further treatment advice. |
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| 相互作用 | THYROXINE WORSENED RESPONSE TO OZONE & ANIMALS DIED FROM OTHERWISE TOLERATED DOSES. ANTITHYROID DRUGS INCR RESISTANCE TO OZONE. NERVE-BLOCKING AGENTS (PHENOXYBENZAMINE OR ERGOTAMINE) IN THE ADRENALECTOMIZED RAT ALSO INCR RESISTANCE TO OZONE.INCR RESPIRATORY RESPONSE TO HISTAMINE INJECTED SC IN GUINEA PIGS TWO HR AFTER TWO-HR EXPOSURE TO 1 TO 5 PPM OZONE. INCR MORTALITY FROM HIGHER LEVELS OF HISTAMINE COULD BE PRODUCED BY AS LITTLE AS 0.5 TO 1 PPM OZONE. THE INCR SUSCEPTIBILITY PERSISTED UP TO 12 HR AFTER A TWO HR EXPOSURE TO 5 PPM OZONE.ACUTE TOXICITY OF OZONE MAY BE LESSENED BY SIMULTANEOUS OR PRIOR INHALATION OR INJECTION OF ... SULFUR-CONTAINING COMPD. TECHNICAL-GRADE HYDROGEN SULFIDE GIVEN SIMULTANEOUSLY IN MOLAR RATIO OF 2:1 REDUCED MORTALITY PRODUCED BY WHAT WOULD HAVE BEEN LC50 CONCN OF OZONE TO 20%. ... MAJOR PROTECTION WAS OBTAINED BY IP INJECTION OF DIMETHYL DISULFIDE OR HYDROGEN POLYSULFIDE (ABOUT 20 MG/KG) PRIOR TO OZONE EXPOSURE.ELEVEN HEALTHY MALE SUBJECTS AGED 23 TO 38 YR WERE EXPOSED TO PURIFIED AIR, TO NO2, O3, & SO2 ALONE, TO MIXT OF NO2 + SO2, & NO2 + O3 IN MAX ALLOWABLE CONCN, & TO A MIXT OF NO2 + SO2 + O3 IN MAX ALLOWABLE CONCN. RESPIRATORY GAS EXCHANGE FOR O2 DECR & AIRWAY RESISTANCE INCR WAS OBSERVED IN ALL SERIES WITH NO2 IN MAX ALLOWABLE CONCN. THE COMBINATIONS OF NO2 + O3, NO2 + SO2, OR NO2 + SO2 + O3 DID NOT SHOW A STRONGER EFFECT THAN NO2 ALONE.For more Interactions (Complete) data for OZONE (20 total), please visit the HSDB record page. |
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| 標的器官 | Eyes, respiratory system |
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| 健康影響 | At acute levels, ozone is an irritant and lachrymator. At chronically low doses (~40 nmol/mol) there is a great deal of evidence to show that ground level ozone can harm lung function and irritate the respiratory system. Long-term exposure to ozone and the pollutants that produce it is linked to premature death, asthma, bronchitis, heart attacks and other cardiopulmonary problems. Long-term exposure to ozone has been shown to increase risk of death from respiratory illness. An 18-year study on 450,000 people in the US revealed that those living in cities with high ozone levels such as Houston or Los Angeles had an over 30% increased risk of dying from lung disease. Both acute and chronic exposures to ozone can negatively impact the barrier function of the lung, and these exposures can initiate an inflammatory response from the immune system. This immune response involves the release of biologically active mediators that can have adverse effects on the lung tissue itself. Some effects may include the thickening of the air-blood barrier in the lungs, thus reducing the diffusion of oxygen into the blood. Animals exposed to ozone produce and release high amounts of a sugar known as hyaluronan. Hyaluronan has been shown to be directly responsible for causing lung airways to narrow and become irritated. (A15093) |
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| 環境中動態 | A photochemical model was used to quantify the sensitivity of the tropospheric oxidants ozone (O3) and OH to changes in methane (CH4), carbon monoxide (CO), and NO emissions and to perturbations in climate and stratospheric chemistry. Coefficients of the form delta ln[O3]/delta ln[X] and delta ln[OH]/delta ln[X], where [X]= flux of CH4, CO, NO, stratospheric O3, and H2O have been calculated for a number of chemically coherent regions (e.g. nonpolluted continental, nonpolluted marine, urban) at low and middle latitudes. Sensitivities in O3 and OH vary with regional emissions patterns and are nonlinear within a given region as [X] changes. In most cases incr CH4 an CO emissions will suppress OH (neg coefficients) in incr O3 (pos coefficients) except in areas where NO and O3 influenced by pollution are sufficient to incr OH. Stratospheric O3 depletion will tend to decr O3 (except in high NOx areas) and incr OH through enhanced UV photolysis. Incr levels of water vapor (one possible outcome of a global warming) will also decr O3 and incr OH. In most regions, NO, CO and CH4 emission incr will suppress OH and incr O3, but these trends may be opposed by stratospheric O3 depletion and climate change. A regional survey of OH and O3 levels suggests that the tropics have a pivotal role in determining the earth's future oxidizing capacity.Ozone concn above 80 ppb are common in the East U.S. in spring and summer, but they are unusual in the West, and ozone shows considerably more day-to-day variability in the East. Variations in ozone levels are highly correlated over distances of several hundred kilometers in the East, indicating that high values are associated with episodes of large spatial scale, > 600,000 sq km. There were 10 and 7 such episodes in 1978 and 1979, respectively, between the mo of Apr and Septthey persisted for 3-4 days, on avg, with a range of 2-8 days, and were most common in Jun. Daily max ozone values exceeded 90 ppb at over half the sites during these episodes and were often > 120 ppb at one or more sites. An analysis of the meteorology for each episode shows that they occurred preferentially in the presence of weak, slow-moving, and persistent high-pressure systems. Two episodes that occurred outside the summer half of the yr were associated with unseasonably warm weatheronly 1 episode, in Mar 1978, appeared to reflect a major stratospheric intrusion. Concn of NOx at rural locations in the East are frequently high enough (> 1 ppb) to permit significant photochemical formation of ozone. It is clear that rural ozone in the East in spring and summer is severely impacted by anthropogenic emissions of NOx and hydrocarbons, and that ozone episodes occur when the weather is particularly conducive to photochemical formation of ozone. Ozone episodes were present on 23% of days in May-Aug in the East in 1978-1979.Measurements from the eastern north Pacific stratocumulus regime have been used to study components of the regional ozone budget. The surface destruction rate was determined by eddy correlation of ozone and vertical velocity measured during 8 flights of a low flying aircraft. Significant variability (2580 to 6460 s/m) was found in the measured surface resistanceit was partially correlated with friction velocity but appears to have other controlling influences as well. The mean resistance was 4190 + or - 840 s/m, which is higher (slower destruction) than most previous estimates for seawater. Flux and mean measurements throughout the marine boundary layer were used to estimate the net rate of in-situ photochemical production/destruction of ozone. Averaged over the flights, ozone concn was found to be near steady state, and a net photochemical destruction of 0.02 to 0.07 ng/cu m/sec was diagnosed. Ozone vertical distributions above the boundary layer showed a strongly layered structure with very sharp gradients.The results from a two dimensional model were analyzed to determine the principal modes of balance for ozone (O3) concn in different regions of the stratosphere. The analysis showed that except near the poles, O3 is in photochemical equilibrium above 35 km. In the lower stratosphere, equatorward of 50 degrees, concn of O3 is neither photochemically controlled nor transport controlled, but is set by a balance between transport and chemical processes. The low abundance of O3 in the tropics is a result of the balance between photochemical production and transport out of the region. The seasonal behavior at high latitudes, as evident from the springtime maxima, results from a balance between photochemical removal and transport into the region.REACTION BETWEEN ATOMIC OXYGEN & MOL OXYGEN RESULTS IN FORMATION OF OZONE, THE PRINCIPAL OXIDIZING AGENT OF PHOTOCHEMICAL SMOG. FURTHER REACTIONS INVOLVE OZONE & REACTIVE HYDROCARBONS (OLEFINS) TO PRODUCE MANY PRODUCTS, NATURE OF WHICH IS NOT YET FULLY KNOWN. |
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| 有害作用 | Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. |
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| 暴露経路 | The substance can be absorbed into the body by inhalation.inhalation, skin and/or eye contact |
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| 毒性の概要 | Ozone is a strong oxidant and reacts directly with organic double bonds. When ozone breaks down to dioxygen it gives rise to oxygen free radicals, which are highly reactive and capable of damaging many organic molecules. Moreover, it is believed that the powerful oxidizing properties of ozone may be a contributing factor of inflammation. When inhaled, ozone reacts with compounds lining the lungs to form specific, cholesterol-derived metabolites that are thought to facilitate the build-up and pathogenesis of atherosclerotic plaques. These metabolites have been confirmed as naturally occurring in human atherosclerotic arteries and are categorized into a class of secosterols termed atheronals, generated by ozonolysis of cholesterol's double bond to form a 5,6 secosterol. Ozone has also been shown to form the suspected carcinogen bromate when it is introduced to source water with high bromide concentrations. Studies have also demonstrated an increase in collagen, a structural protein involved in fibrosis, following prolonged ozone exposure. Acute and short-term exposure studies have demonstrated ozone’s effects on lung lipids which include an increase in arachidonic acid (a pro-inflammatory molecule). |
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| Signs and Symptoms | Sore throat. Cough. Headache. Shortness of breath. Laboured breathing.ON CONTACT WITH LIQUID: FROSTBITE.Redness. Pain.irritation eyes, mucous membranepulmonary edemachronic resp diseaseExposure of 0.1 to 1 μmol/mol produces headaches, burning eyes and irritation to the respiratory passages. Exposure to 10 ppm ozone will cause pulmonary edema. Low doses act as a depressant and will induce sleep in certain individuals. |
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| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=10028-15-6] |
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| ICSC Environmental Data | This substance may be hazardous to the environment. Special attention should be given to plants. |
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| Natural Pollution Sources | FORMED LOCALLY IN AIR FROM LIGHTNING, IN STRATOSPHERE BY UV RADIATIONFOUND IN ATMOSPHERE IN VARYING PROPORTIONS (ABOUT 0.05 PPM @ SEA LEVEL), SINCE IT IS PRODUCED CONTINUOUSLY INTHE OUTER LAYERS OF THE ATMOSPHERE BY THE ACTION OF SOLAR UV RADIATION ON THE OXYGEN OF THE AIR. |
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| CERCLA 報告数量 | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Ozone is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 lbs. |
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