基本情報
- CAS
10075-24-8- 標準SMILES
CN(C)CCCN1c2ccccc2CCc2ccccc21.CN(C)CCCN1c2ccccc2CCc2ccccc21.O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O- InChIKey
BPQZYOJIXDMZSX-UHFFFAOYSA-N- 分子式
- C61H64N4O6
- 平均分子量
- 949.2 g/mol
- 単同位体質量
- 948.48258577
概要
Imipramine Pamoate is the pamoate salt of imipramine, a synthetic dibenzazepine derivative with anti-depressant activity. Imipramine pamoate, a tricyclic antidepressant (TCA) potentiates the activity of adrenergic synapses by blocking the re-uptake of norepinephrine and serotonin, thereby preventing their degradation and increasing their availability. This drug also has antimuscarinic and anti-histamine properties, which contribute to its side effects.
名称と識別子
- 優先名称
- Imipramine Pamoate
- IUPAC
- 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;bis(3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine)
- 現地名
- イミプラミンパモ酸塩
- 英語名
- Imipramine pamoate
- 分子式
- C42H40N2O6
- 分子量
- 668.79
名称と別名
Imipramine pamoate10075-24-8Tofranil-PMImipramine embonateMC34P30298DTXSID801434844,4'-Methylenebis(3-hydroxy-2-naphthoic) acid, compound with 10,11-dihydro-N,N-dimethyl-5H-dibenz(b,f)azepine-5-propylamine (1:2)4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethyl-1-propanamine (1:2)RefChem:57885DTXCID6065975233-206-6Imipramine (pamoate)
名称をさらに表示
イミプラミンパモ酸塩イミプラミンエンボン酸塩4,4′-メチレンビス(3-ヒドロキシ-2-ナフタレンカルボン酸)/10,11-ジヒドロ-N,N-ジメチル-5H-ジベンゾ[b,f]アゼピン-5-プロパン-1-アミン,(1:2)Imipramine Pamoate (1338481)10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)4,4'-methylenebis[3-hydroxy-2-naphthoic] acid, compound with 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propylamine (1:2)2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine (1:2)
物性
構造計算による物性
- 極性表面積
- 128 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 10
- 回転可能結合数
- 12
- 重原子数
- 71
- 形式電荷
- 0
- 複雑度
- 859
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 溶解性
- DMSO (Slightly), Methanol (Slightly)
- 外見
- Solid
- 色
- Yellow
- 主な用途
- 医薬品医薬品（低分子化合物）
- InChIKey
- BPQZYOJIXDMZSX-UHFFFAOYSA-N
- SMILES
- N8(c9c(cccc9)CCc%10c8cccc%10)CCCN(C)C.N5(c6c(cccc6)CCc7c5cccc7)CCCN(C)C.Oc1c(c4c(cc1C(=O)O)cccc4)Cc2c3c(cc(c2O)C(=O)O)cccc3
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P264, P270, P273, P301+P317, P308+P316, P321, P330, P391, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Hazard Classes and CategoriesAcute Tox. 4 (100%)
安全データ
- wgk
- WGK 3
- hs_code
- 2933996100
- Hazard Classifications
- Acute Tox. 4 Oral
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
FDA Pharmacological Classification
IMIPRAMINE PAMOATE
Tricyclic Antidepressant [EPC]
MeSH Pharmacological Classification
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
応用分野
使用Imipramine Pamoate is a tricyclic antidepressant.
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