基本情報
- CAS
10161-33-8- 標準SMILES
C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O- InChIKey
MEHHPFQKXOUFFV-OWSLCNJRSA-N- 分子式
- C18H22O2
- 平均分子量
- 270.4 g/mol
- 単同位体質量
- 270.16197994
概要
Trenbolone is a 3-oxo-4 steroid that is estra-4,9,11-triene carrying an oxo group at position 3 and a hydroxy group at position 17beta. It is a synthetic anabolic steroid used for muscle growth in livestock. It has a role as an endocrine disruptor and a plant metabolite. It is a C18-steroid, a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and an anabolic androgenic steroid.
名称と識別子
- 優先名称
- Trenbolone
- IUPAC
- (8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one
- 現地名
- トレンボロン
- 英語名
- Trenbolone
- 分子式
- C18H22O2
- 分子量
- 270.37
名称と別名
Trenbolone10161-33-817beta-TrenboloneTrienbolone(+)-Trenbolone17-beta-TrenboloneTrenbolonum17-beta-Hydroxyestra-4,9,11-trien-3-oneDTXSID0034192RU 2341P53R4420TRDTXCID8014192
名称をさらに表示
トレンボロンα-トレンボロントリエンボロントリエノロンepi-トレンボロンβ-トレンボロン17β-ヒドロキシエストラ-4,9,11-トリエン-3-オン17β-トレンボロン17α-トレンボロン17α-ヒドロキシエストラ-4,9,11-トリエン-3-オントレンボロン標準品Β-トレンボロン標準品17Β-トレンボロン 溶液(1S,3aS,3bS,11aS)-1-ヒドロキシ-11a-メチル-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,11aH-シクロペンタ[a]フェナントレン-7-オンtrenbolon17β-TrenboloneParabolaTrenbolone enthanatetrenbolone (17β-hydroxyestr-4,9,11-trien-3-one)R 2580ru2341Tren 100
CHEBI:35018RU-2341trenbolonaRefChem:6506beta-Trenbolone17|A-TrenboloneTrembolona(8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one
物性
構造計算による物性
- XLogP
- 1.9
- 極性表面積
- 37.3 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 2
- 回転可能結合数
- 0
- 重原子数
- 20
- 形式電荷
- 0
- 複雑度
- 566
実験および物理化学的性質
Drugs
DEA NFLIS-Drug Category -> Steroids
Pharmaceutical
Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds
Human DrugsPharmaceuticals
Endocrine DisruptorsPotential endocrine disrupting compound
Collision Cross Section
192.3 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0034192]
163.3 Ų [M+H]+ [CCS Type: TW]
物理化学的性質
- 融点
- 170 °C · 170°C
- 比旋光度
- 20 · D20 +19° (c = 0.45 in ethanol)
- 沸点
- 490.8 · 490.8±45.0 °C(Predicted)
- 比重(密度)
- 1.19 · 1.19±0.1 g/cm3(Predicted)
- 闪点
- 2 ℃ · 2℃
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- 30 mg/ml; · DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml
- 外見
- liquid
- 酸解離定数(Pka)
- 14.73 · 14.73±0.40(Predicted)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H360 (95.9%): May damage fertility or the unborn child [Danger Reproductive toxicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 74 reports by companies from 6 notifications to the ECHA C&L Inventory.
危険有害性情報
Regulatory InformationREACH registered substance: (8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one (EC: 600-229-1)
Hazard Classes and CategoriesRepr. 1A (95.9%)
安全データ
- wgk
- 3
- rtecs
- KG7752000
- ridadr
- UN 1648 3 / PGII
- risk_code
- 60-36-20/21/22-11
- hazard_code
- T,Xn,F
- safety_code
- 53-22-36/37/39-45-36/37-26-16
- Hazard Classifications
- Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralEye Irrit. 2Flam. Liq. 2
- ストレージクラス
- 3 - Flammable liquids
化学と産業
薬理情報
MeSH Pharmacological ClassificationThese compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.
用途と製造
Use ClassificationPharmaceuticals
応用分野
説明Trenbolone, also known as trienolone or trienbolone, is a kind of anabolic androgenic steroid belonging to the 19-nortestosterone group. It can be supplied to veterinary medicine of livestock in order the boost muscle growth and appetite. It can also enhance the performance of athletes. It has several physiological effects: (1) enhance protein synthesis and nitrogen retention in the muscle tissues, which boost enhanced anabolism; (2) greatly promote insulin-like growth factor-1 (IGF-1) which is a highly effective anabolic hormone; (3) Greatly increase the red blood cell count to boost blood oxygenation which leads to improved muscular endurance; (4) Inhibit glucocorticoid hormones which inhibit the growth of muscle tissue and promote fat. (5) Improve food efficiency.
使用Trenbolone is a controlled substance (anabolic steroid). It is a steroid used on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is administered as a prodrug as an ester conjugate such as [trenbolone acetate], trenbolone enanthate, or trenbolone cyclohexylmethylcarbonate. Plasma lipases then cleave the ester group in the bloodstream leaving free trenbolone.
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