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Dipropylene glycol monomethyl ether

HCID 25484
ノート反応
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
20324-32-7
標準SMILES
COCC(C)OCC(C)O
InChIKey
WGYZMNBUZFHYRX-UHFFFAOYSA-N
分子式
C7H16O3
平均分子量
148.2 g/mol
単同位体質量
148.10994437

概要

Dipropylene glycol methyl ether is a colorless liquid with a weak odor. (USCG, 1999)

名称と識別子

優先名称
Dipropylene glycol monomethyl ether
IUPAC
1-(1-methoxypropan-2-yloxy)propan-2-ol
英語名
Dowanol
分子量
0

名称と別名

PPG-2 methyl etherKino-redRQ1X8FMQ9NArcosolv DPMGlysolv DPMPropanol, 1(or 2)-(2-methoxymethylethoxy)-Ucar solvent 2LMDowanol-50BDPGMEHISOLVE DPMDipropylene glycol, monomethyl etherDTXSID0027983
名称をさらに表示
Dowanol 50bARCOSOLVRefChem:589098DTXCID601766271252-104-234590-94-8Dipropylene glycol methyl etherDipropylene glycol monomethyl ether

データベース識別子

CAS
20324-32-7、34590-94-8、71244-88-7
PubChem CID
25484
DTXSID
DTXSID5027809
UNII
RQ1X8FMQ9N
EC Number
243-733-3、252-104-2
Nikkaji
J103.261E

物性

構造計算による物性

XLogP
-0.1
極性表面積
38.7 Ų
水素結合供与体数
1
水素結合受容体数
3
回転可能結合数
5
重原子数
10
形式電荷
0
複雑度
75.3

実験および物理化学的性質

Chemical ClassesFlammable agents - 2nd degree
SolventsSolvents -> Glycol Ethers (P Series)
Cosmetics · 2 件

Cosmetic ingredients (PPG-2 Methyl Ether) -> CIR (Cosmetic Ingredient Review)

Solvent

FragrancesFragrance Ingredient (Dipropylene glycol monomethyl ether) -> IFRA transparency List
LogP-0.06
Odor · 2 件

MILD ETHER ODOR IN MODERATE CONCN BUT A STRONG OBJECTIONABLE ODOR @ 1000 PPM

Ether-like odor.

TasteBITTER TASTE
Density · 5 件

0.951 at 68 °F (USCG, 1999) - Less dense than water; will float

0.95 at 25/4 °C

0.95

0.951 @25 °C

0.95

Viscosity3.5 CENTIPOISE @ 25 °C
Color/Form · 2 件

COLORLESS LIQUID

Colorless liquid.

Solubility · 4 件

安全と法規制

安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 98.6% (5042 of 5116) of all reports.

Not Classified

Aggregated GHS information provided per 5116 reports by companies from 18 notifications to the ECHA C&L Inventory.

This chemical does not meet GHS hazard criteria for 100% (222 of 222) of all reports.

Not Classified

Aggregated GHS information provided per 222 reports by companies from 2 notifications to the ECHA C&L Inventory.

危険有害性情報

Regulatory Information · 6 件

Chemical: 2-Propanol, 1-(2-methoxy-1-methylethoxy)-

Chemical: Propanol, 1(or 2)-(2-methoxymethylethoxy)-

Propanol, 1(or 2)-(2-methoxymethylethoxy)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propanol, 1(or 2)-(2-methoxymethylethoxy)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 15-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14751

2-Propanol, 1-(2-methoxy-1-methylethoxy)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Propanol, 1(or 2)-(2-methoxymethylethoxy)-: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Propanol, (2-methoxymethylethoxy)-: Environment tier I assessment
Fire HazardsCombustible. Emits toxic fumes under fire conditions. (USCG, 1999)
Fire PotentialMODERATE WHEN EXPOSED TO HEAT OR FLAME
Health Hazards · 1 件

CALL FOR MEDICAL AID. LIQUID: Irritating to skin and eyes. Harmful if swallowed. Remove contaminated clothing and shoes. Flush affected areas with plenty of water. IF IN EYES, hold eyelids open and flush with plenty of water. May be harmful by inhalation, ingestion, or skin absorption. May cause irritation. (USCG, 1999)

化学と産業

薬理情報

Absorption, Distribution and ExcretionABSORBED BY SKIN.

用途と製造

Uses · 6 件

CIR ingredient: PPG-2 Methyl Ether

Used in hydraulic fluids and as a solvent. [ACGIH]

Painting (Solvents) [Category: Paint]

IN MFR OF VARIOUS COSMETICS

SOLVENT IN HARD-SURFACE LIQUID HOUSEHOLD CLEANERS & WATER-BASED SURFACE COATINGS; COUPLING AGENT, EG, IN WATER-BASED POLISHES

Used as a solvent for nitrocellulose & other synthetic resins

U.S. Production · 3 件

2023: 40,000,000 - <55,000,000 lb

(1977) PROBABLY GREATER THAN 2.27X10+6 GRAMS

(1979) PROBABLY GREATER THAN 4.54X10+6 GRAMS

Consumer UsesOther
Industry UsesIntermediate
Methods of ManufacturingBY REACTING PROPYLENE OXIDE WITH THE APPROPRIATE ALCOHOL. BY ALKYLATION OF DIPROPYLENE GLYCOL WITH A DIALKYL SULFATE IN PRESENCE OF A CATALYST.
Household Products · 2 件

Information on 3 consumer products that contain Dipropylene glycol monomethyl ether in the following categories is provided:

Information on 293 consumer products that contain Dipropylene glycol methyl ether in the following categories is provided:

Use Classification · 6 件

EPA Safer Chemical Functional Use Classes -> Solvents

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

EPA Safer Chemical Functional Use Classes -> Solvents

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Fragrance Ingredients

Cosmetics -> Solvent

関連反応

0 件
反応記録を作成

現在のフィルター条件では反応記録がありません。

化合物ノート

読み込み中…

このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート

Miscible (NIOSH, 2024)

MISCIBLE WITH WATER & MANY ORGANIC SOLVENTS

COMPLETELY MISCIBLE WITH ACETONE, ETHANOL, BENZENE, CARBON TETRACHLORIDE, ETHER, METHANOL, MONOCHLOROBENZENE & PETROLEUM ETHER

Miscible

Flash Point · 5 件

166 °F (USCG, 1999)

85 °C

185 °F (85 °C) (CLOSED CUP)

166 °F

180 °F

Hazards Summary · 1 件

Central nervous system depression observed in animal studies; TLV Basis: liver effects and CNS effects; No liver effects when animals exposed to up to 200 ppm for 13 weeks; [ACGIH] An eye and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] See Glycol ethers.

FDA RequirementsDipropylene glycol monomethyl ether is an indirect food additive for use only as a component of adhesives.
Reactive GroupAlcohols and Polyols
EPA Safer Chemical · 2 件

Chemical: 1-(2-Methoxy-1-methylethoxy)-2-propanol

Chemical: Dipropylene glycol methyl ether

FIFRA Requirements · 2 件

Dipropylene glycol monomethyl ether is exempted from the requirement of a tolerance when used as a stabilizer in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.

Dipropylene glycol monomethyl ether is exempted from the requirement of a tolerance when used as a surfactant or a related adjuvant of a surfactant in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals.

Reactivity AlertsPeroxidizable Compound
OSHA Standards · 2 件

Permissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 100 ppm (600 mg/cu m). Skin Designation.

Vacated 1989 OSHA PEL TWA 100 ppm (600 mg/cu m); STEL 150 ppm (900 mg/cu m), skin designation, is still enforced in some states.

安全と保護具

Fire FightingExtinguish with dry chemical, alcohol foam, or CO2. Cool exposed containers with water. (USCG, 1999)
First Aid · 2 件

Excerpt from NIOSH Pocket Guide for Dipropylene glycol methyl ether:

(General first aid procedures)

Exposure Control and Personal Protection50.0 [ppm]
Fire Fighting ProceduresDRY CHEMICAL, CARBON DIOXIDE, MIST, FOAM
Storage Conditions · 1 件

IN GENERAL, MATERIALS ... TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS ... SHOULD BE STORED IN COOL ... VENTILATED PLACE, OUT OF ... SUN, AWAY FROM ... FIRE HAZARD ... BE PERIODICALLY INSPECTED & MONITORED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ... .

Nonfire Spill Response · 1 件

Stop discharge if possible. Call fire department. Avoid contact with liquid. Isolate and remove discharged material. Notify local health and pollution control agencies. Evacuate areas. Should be removed. Chemical and physical treatment. Effect of low concentrations on aquatic life is unknown. May be dangerous if it enters water intakes. Notify local health and wildlife officials. Notify operators of nearby water intakes. (USCG, 1999)

Preventive Measures · 2 件

If dipropylene glycol methyl ether saturates the clothing, promptly remove the clothing and wash or shower.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Allowable Tolerances · 2 件

Dipropylene glycol monomethyl ether is exempted from the requirement of a tolerance when used as a stabilizer in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.

Dipropylene glycol monomethyl ether is exempted from the requirement of a tolerance when used as a surfactant or a related adjuvant of a surfactant in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals.

Respirator RecommendationsNIOSH/OSHA
Threshold Limit Values (TLV) · 3 件

50.0 [ppm]

8 hr Time Weighted Avg (TWA): 100 ppm; 15 min Short Term Exposure Limit (STEL): 150 ppm, skin.

50 ppm [2021]

Permissible Exposure Limit (PEL) · 3 件

100.0 [ppm]

100 ppm (600 mg/m³)

TWA 100 ppm (600 mg/m3) [skin] See Appendix G

Protective Action Criteria (PAC) · 3 件

50 [ppm]

550 [ppm]

3300 [ppm]

毒性情報

Target OrgansEyes, respiratory system, central nervous system
Environmental Fate · 3 件

TERRESTRIAL FATE: In a soil-water matrix, dipropylene glycol monomethyl ether will be highly mobile. Sorption to soil particulates will be minimal. The primary removal mechanism in soil will probably be biodegradation. However, dipropylene glycol monomethyl ether which is on the surface of dry soil may evaporate. (SRC)

AQUATIC FATE: Due to its miscibility in water, dipropylene glycol monomethyl ether is not expected to sorb to sediments or to bioconcentrate. Evaporation from the water to air is also expected to be minimal due to the low vapor pressure and high solubility of dipropylene glycol monomethyl ether. The primary degradation mechanisms in water is probably biodegradation, while photolysis and hydrolysis are probably insignificant. (SRC)

ATMOSPHERIC FATE: Dipropylene glycol monomethyl ether in the atmosphere is estimated to have a half-life of 3.4 hours(1). In addition to photochemical reactions, dipropylene glycol monomethyl ether may be removed from the atmosphere by washout(SRC).

Adverse EffectsNeurotoxin - Acute solvent syndrome
Exposure Routesinhalation, skin absorption, ingestion, skin and/or eye contact
Toxicity SummarySafe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org
Signs and Symptomsirritation eyes, nose, throat; lassitude (weakness, exhaustion), dizziness, headache
Effluent Concentrations · 1 件

Dipropylene glycol monomethyl ether was detected in the final effluents from three different wastewater treatment plants in Illinois(1). Two of the treatment plants received wastewater from a variety of industries, while the third one received wastewater from a petroleum refinery. Dipropylene glycol monomethyl ether concentration, however, was not determined.

Soil Adsorption/MobilityThe high water solubility of dipropylene glycol monomethyl ether suggests that it will not sorb to soils or sediments and, therefore, would be expected to leach through soil. (SRC)
Human Toxicity Excerpts · 5 件

THE SUBSTANCE WAS FOUND NOT TO BE AN IRRITANT TO THE SKIN & PATCH TESTS ON 250 HUMAN SUBJECTS PRODUCED NO SENSITIZATION.

WHILE NO INJURIES FROM THE INDUSTRIAL USE OF DOWANOL 50 B HAVE BEEN RECORDED, HIGH CONCN OF THE VAPOR CAUSE MARKED IRRITATION OF THE NASAL MUCOUS MEMBRANE, WHICH IS DIFFICULT FOR HUMAN BEINGS TO TOLERATE.

... UNDILUTED MATERIAL /WAS APPLIED/ TO SKIN OF HUMAN SUBJECTS. IN ONE GROUP IT ... /REMAINED/ IN DIRECT CONTACT WITH SKIN FOR 5 DAYS, & AGAIN 3 WK LATER FOR 48 HR; IN ANOTHER GROUP ... APPLIED FOR 4-8 HR EVERY OTHER DAY & AGAIN FOR 24-48 HR 3 WK LATER. /NO EVIDENCE OF IRRITATION, SENSITIZATION./

/LEVELS OF 300 TO 400 PPM/ ... WERE VERY DISAGREEABLE TO MAN; LEVELS OF 100 PPM, WHICH MIGHT BE VOLUNTARILY TOLERATED WITHOUT COMPLAINT, WERE CONSIDERED TO BE SAFE WITH RESPECT TO ORGANIC INJURY.

... /DIPROPYLENE GLYCOL MONOMETHYL ETHER/ CAUSED NEITHER IRRITATION NOR SENSITIZATION WHEN TESTED ON HUMAN SUBJECTS. IT IS LOW IN TOXICITY BY INHALATION. HAZARDS TO HEALTH ASSOC WITH HANDLING & ORDINARY USE OF THIS MATERIAL SEEM TO BE MINIMAL.

Artificial Pollution Sources · 1 件

Dipropylene glycol monomethyl ether is used as a component of a variety of industrial and consumer products, (hydraulic brake fluid, cosmetics, paints and coatings, paint and varnish removers, printing inks, textile dyes, floor polishes, cleaners surfactant for oil spills, and pesticide formulations(1-5); these would suggest widespread environmental release(SRC).

Environmental Biodegradation · 1 件

Five-, ten-, and twenty-day BOD values for dipropylene glycol monomethyl ether were reported as 0, 0, and 31%, respectively (expressed as percentage of theoretical oxygen demand)(1). The type of inoculum, however, was not specified. This delayed oxygen demand suggests that an acclimation period is required in order for a dipropylene glycol monomethyl ether-degrading population to become established. Thus, intermittent releases of dipropylene glycol monomethyl ether to the environment or to wastewater treatment plants may also require an acclimation period before significant amounts of dipropylene glycol monomethyl ether are removed(SRC). No information was found on the biodegradation of dipropylene glycol monomethyl ether in soil or natural waters.

Environmental BioconcentrationSince dipropylene glycol monomethyl ether is infinitely soluble in water, it will not be expected to bioconcentrate in aquatic organisms. (SRC)

法規制情報

FDA RequirementsDipropylene glycol monomethyl ether is an indirect food additive for use only as a component of adhesives.
FIFRA Requirements · 2 件

Dipropylene glycol monomethyl ether is exempted from the requirement of a tolerance when used as a stabilizer in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.

Dipropylene glycol monomethyl ether is exempted from the requirement of a tolerance when used as a surfactant or a related adjuvant of a surfactant in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals.

General Manufacturing Information · 4 件

Computer and Electronic Product Manufacturing

2-Propanol, 1-(2-methoxy-1-methylethoxy)-: ACTIVE

Propanol, 1(or 2)-(2-methoxymethylethoxy)-: ACTIVE

THE COMMERCIAL PRODUCT IS BELIEVED TO BE A MIXTURE OF FOUR ISOMERIC FORMS.

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