CAS 13435-12-6 Acetamide, N-(trimethylsilyl)- (HCID 25989)

名称と識別子

優先名称: Acetamide, N-(trimethylsilyl)-
IUPAC: N-trimethylsilylacetamide
現地名: N-トリメチルシリルアセトアミド
英語名: N-(Trimethylsilyl)acetamide
分子式: C5H13NOSi
分子量: 131.25

名称と別名

N-(Trimethylsilyl)acetamide13435-12-6N-TrimethylsilylacetamideACETAMIDE, N-(TRIMETHYLSILYL)-Trimethylsilylacetamide(Acetylamino)trimethylsilaneEINECS 236-565-7NSC 139859BRN 0741928DTXSID80654544-04-00-04011 (Beilstein Handbook Reference)RefChem:551795

名称をさらに表示

N-トリメチルシリルアセトアミドN-(トリメチルシリル)アセトアミドN-TMSアセトアミドN‐(トリメチルシリル)アセトアミドN-トリメチルシリルアセトアミド, 95%trimethylsilylTMSACMH3DK063CMD1YLVNC9C15orf13HEL-S-265HTM-alpha

DTXCID2034205236-565-7C5H13NOSiAcetamide, TMS derivativeMFCD00008671n-trimethylsilyl-acetamideTMS acetamideS18875

データベース識別子

CAS: 13435-12-6
PubChem CID: 25989
DTXSID: DTXSID8065454
EC Number: 236-565-7
Nikkaji: J55.333F

物性

構造計算による物性

極性表面積: 29.1 Å²
水素結合供与体数: 1
水素結合受容体数: 1
回転可能結合数: 1
重原子数: 8
形式電荷: 0
複雑度: 95

物理化学的性質

融点: 46 · 46-49 °C(lit.)
沸点: 84 °C18 · 84 °C18 mm Hg(lit.)
比重(密度): 0.859 · 0.859±0.06 g/cm3(Predicted)
闪点: 135 °F · 135 °F
貯蔵温度: Inert atmosphere,Room Temperature
溶解性: クロロホルム、DMSO、メタノール
酸解離定数(Pka): 18.23 · 18.23±0.46(Predicted)
外見: 結晶質量
色: 白から黄色
水溶解度: 反応する
BRN: 741928 · 741928
安定性: 湿気に敏感
InChI: 1S/C5H13NOSi/c1-5(7)6-8(2,3)4/h1-4H3,(H,6,7)
InChIKey: LWFWUJCJKPUZLV-UHFFFAOYSA-N
SMILES: CC(=O)N[Si](C)(C)C
CAS データベース: 13435 · 13435-12-6(CAS DataBase Reference)
EPAの化学物質情報: Acetamide, N-(trimethylsilyl)- (13435-12-6)

化学的性質

化学的特性WHITE TO YELLOWISH CRYSTALLINE MASS

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 84.4% (38 of 45) of all reports.

Warning

H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (11.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 38 of 45 reports by companies.；There are 4 notifications provided by 7 of 45 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 2 件

Chemical: Acetamide, N-(trimethylsilyl)-

Acetamide, N-(trimethylsilyl)-: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesSkin Irrit. 2 (11.1%)；Eye Irrit. 2 (11.1%)

法規制情報

Regulatory Information · 2 件

Chemical: Acetamide, N-(trimethylsilyl)-

Acetamide, N-(trimethylsilyl)-: Does not have an individual approval but may be used under an appropriate group standard

安全データ

F: 10-21
wgk: 3
tsca: TSCA listed
rtecs: AD0250000
ridadr: 1325
hs_code: 29319090
risk_code: 36/37/38-11
消防法: 危-4-2-III
hazard_code: Xi-F,Xi,F
safety_code: 37/39-26
hazard_class: 4.1
packing_group: III
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2
ストレージクラス: 11 - Combustible Solids

化学と産業

用途と製造

General Manufacturing InformationAcetamide, N-(trimethylsilyl)-: ACTIVE

応用分野

使用N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).

一般的な説明The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied.

調製方法 · 1 件

純化方法Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]