​ペンタカルボニル鉄

Isolate hazard area and deny entry. Stay upwind and keep out of low areas. Isolate area for 1/2 mile in all directions if tank car or truck is involved in fire. Wear positive pressure breathing apparatus and special protective clothing. Cool containers exposed to flames with water until fire is out. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire.

Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer immediately for medical attention.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

Warning: Effects may be delayed 12 to 36 hours. Caution is advised. Emesis may be contraindicated if victim has ingested a mixture of iron, pentacarbonyl and a hydrocarbon solvent or fuel.

General First Aid:

(General first aid procedures)

This material presents a vapor explosion and poison hazard indoors, outdoors, or in sewers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions.

· Wear positive pressure self-contained breathing apparatus (SCBA).

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

0.1 [ppm]

Suitable extinguishing media: For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

Fire fighting: Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode. /Iron oxide fume/

For more Fire Fighting Procedures (Complete) data for Iron pentacarbonyl (6 total), please visit the HSDB record page.

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature 2-8 °C. Heat- and air-sensitive. Light sensitive. Handle and store under inert gas. Rapidly absorbed through skin.

Protect from light and air.

Store separately in an area isolated from flammables, combustibles, or other yellow coded materials. ... Store in a secure poison location. Prior to working with this chemical you should be trained on its proper handling and storage. Before entering confined space where iron pentacarbonyl may be present, check to make sure that an explosive concentration does not exist. Store under nitrogen. Iron pentacarbonyl must be stored to avoid contact with water, since violent reactions occur. Store away from contact with light and air, oxidizers, and other incompatible materials ... . Iron pentacarbonyl should be handled in an automatic mechanized fashion at all times. Containers should be flushed with nitrogen before opening. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition, such as smoking an open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Wherever this chemical is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings.

Because the vapors of /iron pentacarbonyl/ form explosive mixtures with air, this chemical should be stored under /carbon monoxide, carbon dioxide, or nitrogen/... .

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

Evacuate and restrict person not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Do not breathe vapors. Shut off or remove ignition sources in hazard area. Do not touch spilled material. Stop leak if this can be done without risk. Use water spray to reduce vapors. Take up small spills with sand or other noncombustible absorbent material and place into containers for later disposal. Dike far ahead of large spills for later disposal. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the buildup of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.

Initial isolation and protective action distances: Distances shown are likely to be affected during the first 30 min after the materials are spilled and could increase with time. If more than one tank car, cargo tank, portable tank, or large cylinder involved in the incident is leaking, the protective action distance may need to be increased. ... Small spills (from a small package or a small leak from a large package): First: Isolate in all directions 300 ft/100 m. Then: Protect all persons downwind: Day 0.6 mi/0.9 km, Night 1.9 mi/3.1 km. Large spills (from a large package or from many small packages): First: Isolate in all directions 1500 ft/500 m. Then: Protect persons downwind: Day 3.5 mi/5.5 km, Night 5.5 mi/8.9 km.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

ATMOSPHERIC FATE: Iron pentacarbonyl (Fe(CO)5), which has a vapor pressure of 21 mm Hg at 20 °C(1), and would be expected to exist as a vapor in the air(SRC). When exposed to light, iron pentacarbonyl is slowly converted to iron nonacarbonyl(1).

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

IDENTIFICATION AND USE: Iron pentacarbonyl is a colorless to yellow, oily liquid. It is used to make finely divided iron, so-called carbonyl iron, which is used in the manufacture of powdered iron cores for high frequency coils used in the radio and television industry. It is also used as an antiknock agent in motor fuels, and as catalyst and reagent in organic reactions. HUMAN STUDIES: Potential symptoms of overexposure include irritation of eyes, mucous membranes, and respiratory system, as well as headache, dizziness, nausea, vomiting, fever, cyanosis, cough, and dyspnea. Degenerative CNS changes, as well as liver, kidney, and lung injury, may also occur. Death usually occurs in 4-11 days from exposure to lethal concentrations. Vapors of iron pentacarbonyl are extremely toxic and have a strong effect on respiratory organs, and mucous membranes. ANIMAL STUDIES: Rats exposed to iron pentacarbonyl (270 mg/cu m) showed lethargy, respiratory difficulty, 4% carboxyhemoglobin, and some animals were dead the next day. Histological examination revealed lung edema and congestion.

Headache. Dizziness. Laboured breathing. Vomiting. Symptoms may be delayed.

MAY BE ABSORBED! Further see Inhalation.

See Inhalation.

irritation eyes, mucous membrane, respiratory system; headache, dizziness, nausea, vomiting; fever, cyanosis, cough, dyspnea (breathing difficulty); liver, kidney, lung injury; degenerative changes in central nervous system

Initial Medical Examination: A complete history and medical examination: The purpose is to detect pre-existing conditions such as lung, liver, and kidney disease that might place etc ... that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Examination of the respiratory system should be stressed. A 14 x 17 inch chest roentgenogram: ... Surveillance of the lungs is indicated. FVC and FEV. ... Periodic surveillance is indicated. The aforementioned medical examination should be repeated on an annual basis, except that an x-ray is considered necessary only when indicated by results of pulmonary function testing. /Iron oxide fume/

/SIGNS AND SYMPTOMS/ While there is no information on the health effects of exposure of humans to iron pentacarbonyl, the clinical picture of acute exposure to high concentrations is expected to resemble that of nickel carbonyl ... . The immediate symptoms of headache and dizziness are followed in 12 to 36 hours by fever, cyanosis, cough and dyspnea. The primary effects are on the lungs; however, degenerative changes in the central nervous system have also been reported for the related nickel carbonyl.

/SIGNS AND SYMPTOMS/ Potential symptoms of overexposure are irritation of eyes, mucous membranes, respiratory system; headache, dizziness, nausea, vomiting; fever, cyanosis, cough, dyspnea; liver, kidney, lung injury; degenerative CNS changes.

/SIGNS AND SYMPTOMS/ Signs and symptoms of overexposure to /iron pentacarbonyl/ resemble those of /nickel carbonyl/ immediately upon exposure, giddiness and headache, occasionally accompanied by dyspnea and vomiting. Removal from exposure reverses the symptoms, but dyspnea returns in 12-36 hr, accompanied by fever, cyanosis, and cough. Death usually occurs in 4-11 days from exposure to lethal concentrations. Pathological changes consist of pulmonary hepatization, vascular injury, and degeneration of the CNS.

/OTHER TOXICITY INFORMATION/ Vapors of iron pentacarbonyl Fe(CO)5 are extremely toxic and have a strong effect on respiratory organs, and mucous membranes.

/LABORATORY ANIMALS: Acute Exposure/ Rats (Alderley Park; n=4/sex/group) were exposed to pentacarbonyliron concentrations of 270 and 122 ... mg/cu m (33 and 15 ... ppm, respectively), 5.5 hr/day, for 1 and 2 ... days, respectively. In the high-concentration group, animals showed lethargy, respiratory difficulty, 4% carboxyhemoglobin, and 3 animals were dead the next day. Histological examination revealed lung edema and congestion. In the 15-ppm group, similar effects (mortality in 4 animals 3-4 days later, lethargy, respiratory difficulty, lung edema and congestion) were observed. ...

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ ... Rats (SPF-Wistar; n=5/sex/group) were exposed (whole body) to 81.5, 24, and 8.15 mg/cu m (10, 3, 1 ppm, respectively) pentacarbonyliron, 6 hr/day, 5 days/wk, for 28 days. Because of ... mortality in the 10- and 3-ppm group, treatment was discontinued after 1 and 2 exposures, respectively. Two additional test groups were included and exposed to 2.4, and 0.82 mg/cu m (0.3, 0.1 ppm, respectively). In the 10-ppm group, animals showed abdominal respiration, piloerection, reddish crusts on the edges of the nose, deteriorated general state, and squatting posture. All animals were dead or sacrificed moribund by study day 4. Upon postmortem ... examination, there were minimal irritation of the upper respiratory tract ... and effects on the lungs (intensive discoloration in 10/10, minimal to marked interstitial pneumonia in 10/10, minimal to marked regenerative proliferation in 8/10), spleen (strongly reduced size and lymphocyte depletion in 3/10 and 4/10, respectively), mediastinal lymph nodes (2/5 females), and liver (yellowish, grey, or green-brown foci in 4/10). In the 3-ppm group, 50% of the animals were dead or sacrificed moribund by study day 4, showing signs similar to those seen in the 10-ppm group. In the surviving animals (2 males, 3 females), observed without further exposure for about 4 weeks, piloerection and accelerated respiration lasted up to study day 5 and 9, respectively. The absolute and relative lung weights of these animals were increased. Postmortem macroscopic and microscopic examinations revealed some minimal upper respiratory tract irritation ... and effects on the lungs (intensive discoloration in 5/10, minimal to marked interstitial pneumonia in 7/10, minimal to marked regenerative proliferation in 6/10), spleen (lymphocyte depletion in 2/5 females ... ) and liver (foci in 1/5 females). There were no effects on body weight development or on hematological, clinical chemical, and urinalysis parameters. In the animals exposed to 8.15 mg/cu m, 2.4 mg/cu m, and 0.82 mg/cu m ... , no substance-related clinical signs and findings or influence on body weight development were seen. There was a dose-related increase in carboxyhemoglobin (COHb), measured after 17 days on test, which was statistically significant in male animals exposed to 1, 0.3, and 0.1 ppm and in female animals exposed to 1 and 0.3 ppm. The highest percentage of COHb was 2.1. Further, increases in absolute and relative lung weight were found. Postmortem macroscopic and microscopic examination did not reveal compound-related changes.

According to the 2016 TSCA Inventory Update Reporting data, 1 reporting facility estimated the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of iron pentacarbonyl in the United States may be as low as 10 workers and as high as 25 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1822 workers (272 of these are female) were potentially exposed to iron carbonyl in the US(1). Occupational exposure to iron carbonyl may occur through inhalation and dermal contact with this compound at workplaces where iron carbonyl is produced or used(SRC).

Endogenous metals present in tobacco from agricultural practices have been purported to generate metal carbonyls in cigarette smoke. Transition metal catalysts, such as iron oxide, have been investigated for the reduction of carbon monoxide (CO) in cigarette smoke. These studies motivated the development of an analytical method to determine if iron pentacarbonyl [Fe(CO)(5)] is present in mainstream smoke from cigarette models having cigarette paper made with iron oxide. An FT-IR puff-by-puff method was developed and the detection limit was determined using two primary reference spectra from different sources to estimate the amount of Fe(CO)(5) present in a high-pressure steel cylinder of CO. We do not detect Fe(CO)(5) in a single 35 mL puff from reference cigarettes or from those cigarette models having cigarette paper made with iron oxide, with a 30-ppbV limit of detection (LOD). Also, it was shown that a filter containing activated carbon would remove Fe(CO)(5).

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Iron and Related Compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Iron and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or is in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of 0.9% saline (NS) or lactated Ringer's (LR) /SRP: "To keep open", minimal flow rate/. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Iron and Related Compounds/

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. ... Keep victim quiet and maintain normal body temperature. Medical observation is recommended for 24-48 hr after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a corticosteroid spray.

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Iron pentacarbonyl is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 lbs.

Iron, pentacarbonyl-

1.00

10,000

Flammable chemical that can be released at a facility.