ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
化工社オープンプロジェクト：[email protected]AIアクセス：llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.7.8
  1. ホーム
  2. /化合物

クロルプロパミド

Chlorpropamide

HCID 2727
ノート反応
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
94-20-2
標準SMILES
CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
InChIKey
RKWGIWYCVPQPMF-UHFFFAOYSA-N
分子式
C10H13ClN2O3S
平均分子量
276.74 g/mol
単同位体質量
276.0335411

概要

Chloropropamide is a white crystalline powder with a slight odor. (NTP, 1992)

名称と識別子

優先名称
Chlorpropamide
IUPAC
1-(4-chlorophenyl)sulfonyl-3-propylurea
現地名
クロルプロパミド
英語名
Chlorpropamide
分子式
C10H13ClN2O3S
分子量
276.74

名称と別名

chlorpropamide94-20-2DiabineseGlucamideDiabeneseMelitase4-chloro-N-(propylcarbamoyl)benzenesulfonamideClorpropamidaClorpropamideClorpropamidProdiabenChlorpropamidum
名称をさらに表示
1-(4-クロロフェニルスルホニル)-3-プロピル尿素クロルプロパミド4-クロロ-N-(プロピルカルバモイル)ベンゼンスルホンアミドジアベトラールジアビネース1-(p-クロロフェニルスルホニル)-3-プロピル尿素クロロネーズ1-[(p-クロロフェニル)スルホニル]-3-プロピル尿素N-(プロピルカルバモイル)-4-クロロベンゼンスルホンアミドカタニル4-クロロ-N-[(プロピルアミノ)カルボニル]ベンゼンスルホンアミドアベマイドクロロプロパミドクロルプロプアミドクロルプロパミド (JP17)p607P-607u-3818u-9818OradianAdiabenAsucrolCatanilGlisemaMeldian
1-(p-Chlorobenzenesulfonyl)-3-propylurea1-Propyl-3-(p-chlorobenzenesulfonyl)ureaN-(4-Chlorophenylsulfonyl)-N'-propylureaN-(p-Chlorobenzenesulfonyl)-N'-propylureaN-Propyl-N'-(p-chlorobenzenesulfonyl)urea1-(p-Chlorophenylsulfonyl)-3-propylureaDTXSID90203224-chloro-N-[(propylamino)carbonyl]benzenesulfonamide

物性

構造計算による物性

XLogP
2.3
極性表面積
83.7 Ų
水素結合供与体数
2
水素結合受容体数
3
回転可能結合数
4
重原子数
17
形式電荷
0
複雑度
345

実験および物理化学的性質

DrugsPharmaceuticals -> Listed in ZINC15
LogP · 3 件

log Kow= 2.27

1.8

3.21

Odor · 2 件

SLIGHT ODOR

Odorless

Color/Form · 3 件

Crystals from dil ethanol

WHITE, CRYSTALLINE POWDER

White, crystalline powder

Solubility · 5 件

less than 1 mg/mL at 57 °F (NTP, 1992)

2.2 mg/ml in water @ pH 6; practically insol in water @ pH 7.3; sol in alcohol; moderately sol in chloroform; sparingly sol in ether, benzene

In water, 258 mg/l @ 37 °C

1.57e-01 g/L

>41.5 [ug/mL] (The mean of the results at pH 7.4)

Human Drugs · 4 件

Breast Feeding; Lactation; Milk, Human; Hypoglycemic Agents; Sulfonylurea Compounds

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Pharmaceuticals

Melting Point · 4 件

261 to 264 °F (NTP, 1992)

129.2-129.8

127-129 °C

127 - 129 °C

Physical Description · 2 件

Chloropropamide is a white crystalline powder with a slight odor. (NTP, 1992)

安全と法規制

安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 4 件

Warning

H312+H332 (40.6%): Harmful in contact with skin or if inhaled [Warning Acute toxicity, dermal; acute toxicity, inhalation]

P203, P261, P271, P280, P302+P352, P304+P340, P317, P318, P321, P362+P364, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 69 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Other Safety InformationIMAP assessments - Benzenesulfonamide, 4-chloro-N-[(propylamino)carbonyl]-: Environment tier I assessment
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards · 1 件

SYMPTOMS: Symptoms of exposure to this chemical may include hypoglycemia, nausea, vomiting, diarrhea, anorexia, hunger, pruritus, urticaria, maculopapular eruptions, leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, pancytopenia, eosinophilia, hepatic porphyria, jaundice and disulfiram-like reactions.

FDA Requirements · 1 件

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

Reactive GroupAmides and Imides
Special ReportsDHEW/NCI; Bioassay of Chlorpropamide for Possible Carcinogenicity p.vii (1978) Technical Rpt Series No. 45 DHEW Pub No. (NIH) 78-845

化学と産業

薬理情報

ATC Code · 2 件

A - Alimentary tract and metabolism

QA - Alimentary tract and metabolism

Protein BindingHighly bound to plasma proteins.
Pharmacodynamics · 1 件

Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chlorpropamide is twice as potent as the related second-generation agent glipizide.

Mechanism of Action · 5 件

Sulfonylureas such as chlorpropamide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

...ACTION OF SULFONYLUREAS APPEARS TO BE STIMULATION OF RELEASE OF INSULIN FROM BETA CELLS. ...TO BE EFFECTIVE, PT MUST HAVE SOME FUNCTIONAL ISLET CELLS... /HYPOGLYCEMIC SULFONYLUREAS/

Sulfonylureas cause hypoglycemia by stimulating insulin release from pancreatic beta cells. Their effects in the treatment of diabetes ... are more complex. /Sulfonylureas/

Sulfonylureas are now...thought to act by a number of different mechanisms. 1. ...produce a depolarization of the pancreatic islet beta cell membrane potassium ion permeability. This results in a release of preformed insulin into the circulation and occurs mostly in non-insulin dependent diabetics. 2. ...reduce basal glucose output from the liver... 3. increase insulin receptor binding... 4. ...increasing intracellular levels of AMP... 5. increase insulin secretion by suppressing the release of glucagon and somatostatin from alpha and delta pancreatic cells. /Sulfonylureas/

Sulfonylureas lower blood glucose in NIDDM by directly stimulating the acute release of insulin from functioning beta cells of pancreatic islet tissue by an unknown process that involves a sulfonylurea receptor on the beta cell. Sulfonylureas inhibit the ATP potassium channels on the beta cell membrane and potassium efflux, which results in depolarization and calcium influx, calcium-calmodulin binding, kinase activation, and release of insulin containing granules by exocytosis, an effect similar to that of glucose. Insulin is a hormone that lowers blood glucose and controls the storage and metabolism of carbohydrates, proteins, and fats. Therefore, sulfonylureas are effective only in patients whose pancreata are capable of producing insulin. /Sulfonylurea antidiabetic agents/

関連反応

1 件
反応記録を作成
HRID 461424 の反応式
HRID 461424生成物としてuspto-grants-1977_12

化合物ノート

読み込み中…

このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート

データベース識別子

CAS
94-20-2
PubChem CID
2727
DTXSID
DTXSID9020322
ChEMBL
CHEMBL498
ChEBI
CHEBI:3650
UNII
WTM2C3IL2X
EC Number
202-314-5
Nikkaji
J3.944F

Solid

Stability/Shelf LifeDECOMP IN ALKALI
Dissociation Constants · 2 件

5.13

pKa (H20)= 5.13; pKa (Diox-H2O)= 6.10 (mean of two values)

Collision Cross Section · 2 件

158.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

168.62 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

物理化学的性質

融点
128 °C · 128 °C
沸点
302 °C · 302°C (rough estimate)
比重(密度)
1.3046 · 1.3046 (rough estimate)
屈折率
1.63 · 1.6300 (estimate)
貯蔵温度
Sealed in dry,Room Temperature
溶解性
クロロホルム（少量）、メタノール（少量）
外見
Solid
酸解離定数(Pka)
4.8 · pKa 4.8 (Uncertain)
色
白色～淡黄色
水溶解度
エタノール (1:12)、アセトン (1:5)、クロロホルム (1:9)、アルカリ金属水酸化物溶液に可溶。水とよく混ぜないでください。
Merck
14 · 14,2186
安定性
安定。可燃性。
主な用途
法医学と毒物学医薬品（低分子化合物）
InChI
1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)
InChIKey
RKWGIWYCVPQPMF-UHFFFAOYSA-N
SMILES
CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
CAS データベース
94 · 94-20-2(CAS DataBase Reference)
EPAの化学物質情報
Chloropropamide (94-20-2)

化学的性質

化学的特性white crystalline powder

Reactivity Profile · 1 件

A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesAcute Tox. 4 (98.6%)

安全と保護具

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Disposal Methods · 1 件

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

毒性情報

Interactions · 5 件

DRUGS THAT MAY INCR RISK OF HYPOGLYCEMIA...INCL OTHER HYPOGLYCEMIC AGENTS, SULFONAMIDES, PROPRANOLOL, SALICYLATES, PHENYLBUTAZONE, PROBENECID, DICUMAROL, CHLORAMPHENICOL, MAO INHIBITORS, & ALCOHOL. /SULFONYLUREAS/

Allopurinol or its metabolites might compete with chlorpropamide for renal tubular secretion and can result in an increased chlorpropamide effect in an occasional patient.

A disulfiram like reaction, which is characterized primarily by flushing of the face, neck, and arms, may occur with any of the sulfonylureas when alcohol is ingested concurrently ... . /Sulfonylurea antidiabetic agents/

The risk of hypoglycemia may be increased or prolonged when moderate or large amounts of alcohol have been consumed concurrently with sulfonylurea antidiabetic agents use; small amounts of alcohol taken with meals do not usually result in hypoglycemia. /Sulfonylurea antidiabetic agents/

For more Interactions (Complete) data for CHLORPROPAMIDE (19 total), please visit the HSDB record page.

Ongoing Test Status · 1 件

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=94-20-2]

Human Toxicity Excerpts · 3 件

MAY CAUSE HYPOGLYCEMIC REACTIONS...COMA... THIS IS A ... PROBLEM IN ELDERLY PT WITH IMPAIRED HEPATIC OR RENAL FUNCTION... OTHER SIDE EFFECTS... NAUSEA & VOMITING, CHOLESATIC JAUNDICE, AGRANULOCYTOSIS, APLASTIC & HEMOLYTIC ANEMIAS... /SULFONYLUREAS/

...WATER RETENTION CAN BE LIFE THREATENING IN PT WITH TENDENCY TO RETAIN WATER...

Coma or altered mental status is generally the most important presenting sign in the majority (90%) of patients who have ingested excessive doses of the sulfonylureas ... /Sulfonylurea/

Carcinogen Classification · 6 件

Chlorpropamide

TR-045: Bioassay of Chlorpropamide for Possible Carcinogenicity (CASRN 94-20-2) (1978 )

11/28/77

No Evidence

No Evidence

No Evidence

Drug Induced Liver Injury · 6 件

Drug Induced Liver Injury Rank (DILIrank 2.0)

Chlorpropamide

vLess-DILI-concern

2

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

Non-Human Toxicity Excerpts · 5 件

HAS PRODUCED CORNEAL OPACITIES IN RATS...

TERATOGENESIS IN ANIMALS HAS BEEN OBSERVED TO FOLLOW ADMIN OF LARGE DOSES.

10% to 15% of patients who receive these drugs, particularly chlorpropamide, develop an alcohol induced flush ... may also cause hyponatremia ...

WHEN FED TO FISCHER 344 RATS (3000 OR 6000 PPM FOR 103-105 WK) & B6C3F1 MICE (3317 & 6635 PPM), CHLORPROPAMIDE WAS NON-CARCINOGENIC.

For more Non-Human Toxicity Excerpts (Complete) data for CHLORPROPAMIDE (6 total), please visit the HSDB record page.

National Toxicology Program Studies · 1 件

A bioassay of chlorpropamide for possible carcinogenicity was conducted by administering the test material in feed to Fischer 344 rats and B6C3F1 mice. Groups of 35 rats and 35 mice of each sex were administered chlorpropamide as follows: rats 5 days/wk for 103 to 105 wk at 3,000 or 6,000 ppm, and mice 5 days wk for 34 wk at 5,000 or 10,000 ppm, followed by 70 wk at 2,500 or 5,000 ppm. The time weighted average doses for mice were 3,317 ppm for low dose males and females, and 6,635 ppm for high dose males and females. Matched controls consisted of groups of 15 untreated rats and 15 untreated mice of each sex. All surviving rats and mice were /sacrificed/ at 103 to 105 wk. Mean body weights of both low and high dose rats were lower than those of matched controls throughout the study. In mice, doses were reduced at week 34, due to early deaths in the high dose groups; following this adjustment the treated mice gained weight, but the weights never reached those of controls. Survival of treated rats and the low dose mice was adequate for meaningful statistical analyses of the incidences of tumors. In both rats and mice, the incidences of tumors among the treated groups were not significantly incr in comparison with matched controls. It is concluded that under the conditions of this bioassay, chlorpropamide was not carcinogenic in Fischer 344 rats or B6C3F1 mice.

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Non-Human Toxicity Values · 5 件

LD50 RATS ORAL 2390 MG/KG

LD50 RATS INTRAVENOUS 590 MG/KG

LD50 DOGS INTRAVENOUS 575 MG/KG

LD50 DOGS ORAL 800 MG/KG

LD50 MICE ORAL 1680 MG/KG

法規制情報

FDA Requirements · 1 件

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

安全データ

wgk
3
rtecs
YS6650000
毒性
LD50 i.p. in rats: 580 mg/kg (Goldenthal)
hs_code
29350090
risk_code
20/21/22-40
hazard_code
Xn
safety_code
22-36
Hazard Classifications
Acute Tox. 4 OralRepr. 2
ストレージクラス
11 - Combustible Solids
有毒物質データの
94-20-2(Hazardous Substances Data)
Biological Half-Life · 3 件

Approximately 36 hours with interindividual variation ranging from 25-60 hours. Duration of effect persists for at least 24 hours.

Chlorpropamid has a long half-life (24 to 48 hours).

Half-life...24-48 /hours/ /from table/

Metabolism/Metabolites · 6 件

Up to 80% of dose is metabolized likely through the liver to to 2-hydroxylchlorpropamide (2-OH CPA), p-chlorobenzenesulfonylurea (CBSU), 3-hydroxylchlorpropamide (3-OH CPA), and p-chlorobenzenesulfonamide (CBSA); CBSA may be produced by decomposition in urine. It is unknown whether chlorpropamide metabolites exert hypoglycemic effects.

...METABOLISM OF CHLORPROPAMIDE IS INCOMPLETE, AND ABOUT 20% OF THE DRUG IS EXCRETED UNCHANGED

...SOME HYDROLYTIC BREAKDOWN OF ACTUAL UREA MOIETY HAS BEEN DETECTED, RESULTING IN FORMATION OF SULFONAMIDE DERIV... RECENT EVIDENCE SUGGESTS THIS...TO BE ARTIFACTUAL & NOT A GENUINE METABOLITE...

FOLLOWING PER ORAL ADMIN TO MAN OF TRITIATED CHLORPROPAMIDE...80% OF DOSE WAS EXCRETED...DURING 7-DAY PERIOD. METABOLITES...WERE P-CHLOROBENZENESULFONAMIDE...[(P-CHLOROPHENYL)SULFONYL]UREA... 1-[(P-CHLOROPHENYL)SULFONYL]-3-(2-HYDROXYPROPYL)UREA. ..&.1-[(P-CHLOROPHENYL)SULFONYL]-3-(3-HYDROXYPROPYL)UREA...

...DIABETIC PT WERE ADMIN.../CHLORPROPAMIDE/... AT...250-500 MG...PRODUCTS EXCRETED...INCL.../(P-CHLOROPHENYL)SULFONYLUREA/ (21%)... /P-CHLOROBENZENESULFONAMIDE/ (2%), 2-HYDROXYCHLORPROPAMIDE (55%), & 3-HYDROXYCHLORPROPAMIDE (2%).

For more Metabolism/Metabolites (Complete) data for CHLORPROPAMIDE (6 total), please visit the HSDB record page.

FDA Pharmacological Classification · 5 件

WTM2C3IL2X

CHLORPROPAMIDE

Established Pharmacologic Class [EPC] - Sulfonylurea

Chemical Structure [CS] - Sulfonylurea Compounds

Chlorpropamide is a Sulfonylurea.

MeSH Pharmacological ClassificationSubstances which lower blood glucose levels.
Absorption, Distribution and Excretion · 6 件

Readily absorbed from the GI tract. Peak plasma concentrations occur within 2-4 hours and the onset of action occurs within one hour. The maximal effect of chlorpropamide is seen 3-6 hours following oral administration.

80-90% of a single oral dose is excreted in the urine as unchaged drug and metabolites within 96 hours.

...EFFECTIVELY ABSORBED FROM GI TRACT ...

Excreted (percentage)...60 /from table/

... 20% excreted unchanged; ... /from table/

Chlorpropamide is readily absorbed from the GI tract following oral administration. Following oral administration of a single dose, the drug is detectable in plasma within 1 hour and peak plasma chlorpropamide concentrations occur within 2-4 hours.

Cellular LocationsCytoplasm

用途と製造

Uses · 3 件

Antidiabetic

MEDICATION

MEDICATION (VET)

Methods of ManufacturingMarshall, Sigal, J Org Chem 23, 927 (1958); Brit Pat 853,555 (1960 to Pfizer)...
Formulations/Preparations...usually administered in a daily dose of 100 to 250 mg, whil 750 to 1000 mg is maximal.
Use ClassificationPharmaceuticals
応用分野 · 5 件

解説クロルプロパミド，経口抗糖尿病薬の一つで，スルフォニル尿素誘導体に属する。成人型糖尿病患者および正常人の血糖を下降させる。若年型糖尿病にはほとんど無効。ランゲルハンス島のβ細胞を刺激してインスリンの分泌を促進すると考えられている。グルカゴンの分泌，肝臓でのブドウ糖の生成も抑制する。消化管からの吸収はよい。排泄が遅く，半減期は 35～40時間である。副作用は少いが，皮疹，胃腸障害，白血球減少，黄疸，心臓血管障害，アルコール耐性低下による中毒などがあげられる。肝臓や腎臓障害を起せば低血糖になりやすい。

用途スルホニル尿素剤（SU 剤）です。 膵β 細胞膜のSU 受容体と結合してカリウム チャネルを閉じることによりインスリン分泌 を促進します。

用途スルホニル尿素剤（SU剤）です。 膵β細胞膜のSU受容体と結合してカリウム チャンネルを閉じることによりインスリン分 泌を促進します。

使用Chlorpropamide is a sulfonylurea derivative. Chlorpropamide is a long acting hyopglycemic agent. Chlorpropamide is used in the treatment of diabetes metilus type 2. Chlorpropamide acts to increase the secretion of insulin and is not effective in patients who do not have pancreatic beta cell function.

一般的な説明Chlorpropamide is 4-chloro-N-[(propylamino)carbonyl]benzenesulfonamide; or 1-[(p-chlorophenyl)sulfonyl]-3-propylurea; or 1-(p-chlorobenzenesulfonyl)-3-propylurea(Diabinese, generic). The p-chlorophenyl moiety is quite resistantto P450-mediated hydroxylations; hence, blood levelsof the drug are sustained for a markedly long length of time,as aliphatic hydroxylation constitutes most of the clearance,and this happens relatively slowly. Although the -hydroxyland (ω–1)-hydroxyl metabolites (the latter formed in muchgreater portion) exert hypoglycemic potencies not much lessthan does the parent drug, elimination of these by conversion to the corresponding glucuronides occurs more rapidly thanhydroxylation of chlorpropamide, so blood levels of thesemetabolites remain low, and thus they probably do not makean appreciable contribution to the hypoglycemic action ofthis drug in clinical application. Removal of the entire propylside chain (oxidative N-dealkylation) also occurs to a significantextent (up to 20% of an orally administered dose), creatingthe inactive metabolite p-chlorobenzenesulfonylurea,about 10% of which degrades to the corresponding benzenesulfonamide.

調製方法

純化方法Crystallise the urea from aqueous EtOH. [Beilstein 11 IV 119.]

上流・下流製品情報

上流原料

イソシアン酸 プロピル4-クロロベンゼンスルホンアミドブチルアミドトリエチルアミン

サプライヤー100 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
武汉欣扬瑞和化学科技有限公司153-07155313 15307155313 · [email protected]
河北创海生物科技有限公司+86-86-13131129325 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
Jai Radhe Sales+(91)-(79)-26431096/65255722 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
江西瑞威尔生物科技有限公司400-880-2824 18107960669 · [email protected]
湖南瑞威尔生物科技有限公司18627957289 18173226957 · [email protected]
江西瑞威尔生物科技有限公司18502728206 · [email protected]
湖北威德利化学试剂有限公司17771473825 13385289472 · [email protected]
江西瑞威尔生物科技有限公司18502762009 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
上海隆盛化工有限公司58099637 13585536065 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
上海瀚香生物科技有限公司177-54423994 17754423994 · [email protected]
ChemeGen 中国18818260767 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
天津希恩思生化科技有限公司400 638 7771 · [email protected]
斯百全化学（上海）有限公司021-021-021-67601398-809-809-809 15221380277 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
武汉普洛夫生物科技有限公司17612776928 · [email protected]
南京世洲生物科技有限公司13675144456 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18602735115 · [email protected]
雷丁试剂0510-85629785 18013409632 · [email protected]
上海创赛科技有限公司400-6087598 15021221957 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海御略医药科技有限公司021-60345187 13671753212 · [email protected]
杭州杰恒化工有限公司0571-87396432 · [email protected]
陕西缔都医药化工有限公司029-81024372 17792795018 · [email protected]
凯试（上海）科技有限公司021-50135380 · [email protected]
TargetMol中国（陶术生物）021-021-33632979 15002134094 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
九鼎化学（上海）科技有限公司4009209199 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
湖北威德利化学试剂有限公司18327179646 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
湖北魏氏化学试剂股份有限公司13125137732 18686406941 · [email protected]
上海珞珐生化科技有限公司021-51111890 15317326293 · [email protected]
陕西缔都医药化工有限公司+86-29-81139210 +86-17392587031 · [email protected]
補足説明 · 1 件

定義ChEBI: An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypogly aemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.