(S)-3-アミノ-2-(tert-ブトキシカルボニルアミノ)プロピオン酸

用途有機合成原料。

使用Reactant for:Protein assembly directed by synthetic molecular recognition motifsSolid phase synthesis of gramicidin S cyclic analogs with antibiotic and hemolytic activitiesSynthesis of HCV protease inhibitor modified analogsSolid phase synthesis of peptidic V1a receptor agonistsDirected peptide assembly at lipid-water interface

製造方法The raw material was dissolved inabsolute ethanol (5 mL), and the reaction flask was immersed in a water bath at 25 C. To the alcoholicsolution, 10% palladium-carbon (22.9 mg) and 1,4-cyclohexadiene (10 equivalents with respect to4; 0.47 mL, 5.0 mmol) were added, and the mixture was allowed to react under magnetic stirringovernight. After filtration over a short pad of Celite 545, the solvent was evaporated under reducedpressure conditions, and the solid residue was partitioned in a 1:1 (v/v) H2O/EtOAc mixture (10 mL).The aqueous phase was separated, back extracted with EtOAc (3 10 mL), concentrated under reducedpressure conditions, and lyophilized.Finally, the target product Boc-Dap-OH is obtained.