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硫酸タリウム

Thallic sulfate

HCID 27758
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基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
16222-66-5
標準SMILES
O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].O=S(=O)([O-])[O-].[Tl+3].[Tl+3]
InChIKey
BXBMHLIYMZRCNK-UHFFFAOYSA-H
分子式
O12S3Tl2
平均分子量
697 g/mol
単同位体質量
697.80404

名称と識別子

優先名称
Thallic sulfate
IUPAC
bis(thallium(3+));trisulfate
現地名
硫酸タリウム
英語名
dithallium tris(sulphate)
分子式
H3O4STl
分子量
303.46

名称と別名

THALLIC SULFATEBithallium trisulfateDithallium tris(sulphate)Thallium(III) sulfateSulfuric acid, thallium(3+) salt (3:2)Dithallium tris(sulfate)HSDB 6359Sulfuric acid, thallium(3+) saltEINECS 240-349-8UNII-8L51999Z6V8L51999Z6VDTXSID90890770
名称をさらに表示
硫酸タリウム
THALLIUM SULFATE (TL2(SO4)3)RefChem:189084Thallium sulfate (T12(SO4)3) (6CI,7CI)DTXCID30103112616222-66-5thallium(3+);trisulfateSCHEMBL5481301THALLIUM SULFATE [HSDB]

データベース識別子

CAS
16222-66-5
PubChem CID
27758
DTXSID
DTXSID90890770
UNII
8L51999Z6V
EC Number
240-349-8

物性

構造計算による物性補完中

極性表面積
266 Ų
水素結合供与体数
0
水素結合受容体数
12
回転可能結合数
0
重原子数
17
形式電荷
0
複雑度
62.2

実験および物理化学的性質

Chemical ClassesMetals -> Metals, Inorganic Compounds
DecompositionWhen heated to decomposition it emits acrid smoke and irritating vapors.
Physical DescriptionCannot be isolated because it is extremely unstable; [HSDB]
Other Experimental Properties · 3 件

Thallium(III) forms some organo-metallic compounds ... . /Thallium(III) ion/

Thallic sulfate is extremely unstable and therefore cannot be isolated.

Exists in two oxidation states, /thallous/ (Tl(I)) and /thallic/ (Tl(III)). /Thallium/

物理化学的性質

融点
102 · 102-105 °C
溶解性
2 O · sol water, organic solvents;reacts with H2O.
色
colorless leaflets
EPAの化学物質情報
Sulfuric acid, thallium(3+) salt (3:2) (16222-66-5)

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

危険有害性情報

Regulatory InformationChemical: Sulfuric acid, thallium(3+) salt (3:2)
Other Safety InformationEvaluation - Chemicals not considered for in depth evaluation - Not commercially active in Australia
Hazards SummaryHighly unstable and cannot be isolated; [HSDB] See Thallium and the linked occupational disease.
Special Reports · 5 件

USEPA; Ambient Water Quality Criteria Doc: Thallium (1980) EPA 440/5-80-074

RANGEL GUERRA R ET AL; THALLIUM INTOXICATION: CLINICAL EXPERIENCE WITH 14 CASES; REV INVEST CLIN 32 (4): 381-90 (1980). CLINICAL EXPERIENCE WITH 14 CASES OF THALLIUM INTOXICATION IS DISCUSSED.

Ludolph A et al; Trace Elem Med 3 (3): 121-5 (1986). Clinical and electrophysiological data from chronic thallium exposure in cement plant workers are presented.

Sharma J et al; Toxicol Environ Chem 11 (2) (1986). A review with 152 references on environmental pollution by thallium, and its toxicity and metabolism in humans and laboratory animals.

For more Special Reports (Complete) data for THALLIC SULFATE (7 total), please visit the HSDB record page.

FIFRA RequirementsCancelled and suspended, all products.
OSHA StandardsPermissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 0.1 mg/cu m. Skin Designation. /Thallium, soluble compounds, as Tl/
Clean Water Act RequirementsToxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Thallium and cmpd/
State Drinking Water Guidelines · 2 件

(AZ) ARIZONA 13 ug/l /Thallium/

(MN) MINNESOTA 0.6 ug/l /Thallium/

Federal Drinking Water Standards

化学と産業

薬理情報

Mechanism of Action · 3 件

... STUDY INVOLVING /THALLIUM SOLUBLE SALTS EFFECTS ON MOUSE CELL CULTURES SHOWED/ ... CYTOPATHIC EFFECTS ... GREATLY ENLARGED MITOCHONDRIA IN AXONS OF PERIPHERAL NERVE FIBERS. ... MECHANISM /CONCERNS INACTIVATION OF/ ... SH GROUPS THAT /ALLOW/ ... INCR PERMEABILITY OF MITOCHONDRIA LEADING TO WATER INFLUX & SWELLING. /THALLIUM CMPD/

TRIVALENT THALLIUM COMPOUNDS ARE SOMEWHAT LESS TOXIC THAN ARE THALLIUM ION COMPOUNDS ... THALLIUM ACTS AS A MITOTIC AGENT & GENERAL CELLULAR POISON. CELLULAR ACCUM OF THALLIUM IN MUSCLE & OTHER TISSUES CAUSES DERANGEMENT OF NORMAL CELLULAR METABOLISM ... HIGH THALLIUM CONCN IN BLOOD AGGLUTINATES ERYTHROCYTES & LYSES THEM FOLLOWING THALLIUM ION ACCUMMULATION WITHIN ERYTHROCYTES. /THALLIUM SALTS/

Thallium inhibits enzymes, but nothing is really known of a biochemical lesion. In fatal cases, there usually is extensive peripheral paralysis and cardiovascular involvement. The immediate cause of death may be peripheral respiratory failure of cardiac arrest. /Thallium/

Biological Half-Life · 1 件

BODY BURDEN AS % OF ADMIN DOSE WAS DETERMINED IN RATS FOLLOWING ADMIN OF (204)THALLIUM ... OVER A PERIOD OF 21 DAYS. BODY CLEARANCE /OCCURRED/ ... EXPONENTIALLY WITH HALFTIME 3.3 DAYS ... AT THE END OF 21 DAYS ... 1% OF ADMIN DOSE REMAINED. ... WITH BIOLOGICAL HALF-TIME OF 3.3 DAYS ... DAILY DOSING /GIVES/ AN EQUILIBRIUM ... @ 20 DAYS. /SOLUBLE THALLIUM SALTS/

Absorption, Distribution and Excretion · 2 件

THE DISTRIBUTION OF THALLIUM WAS DETERMINED IN 57 AUTOPSIED TISSUES, INCL BLOOD, OF A PATIENT WHO HAD BEEN ORALLY ADMIN 500 mCi THALLOUS NITRATE (TlNO3) FOLLOWED BY ... 45 MG DOSES ... THALLIUM(I) SULFATE (Tl2SO4) ... UNTIL 225 MG HAD BEEN GIVEN. THE BLOOD SHOWED A RAPID RISE WITHIN 2 HR TO A LEVEL OF 3% OF THE ADMIN RADIOISOTOPE ... TO 1.6%. SOME SPECIFIC LOCALIZATION OF THALLIUM ... WAS FOUND IN THE SCALP HAIR, KIDNEYS, HEART MUSCLE, PRIMARY BONE TUMOR, AND SPLEEN, IN THAT DECREASING ORDER. ... CLOSELY FOLLOWED BY ADRENAL MEDULLA, BONE TUMOR FROM LUNG, PANCREAS, SCALP SKIN, AND LIVER, RIB MARROW, THYROID, ADRENAL CORTEX, AND PITUITARY. ... A DIFFERENT DISTRIBUTION PICTURE WAS FOUND IN THE RAT ... INJECTED WITH 23 UG TlNO3. ... 2 DAYS AFTER DOSING, THE KIDNEYS CONTAINED THE HIGHEST CONCN FOLLOWED BY THE GUT, GONADS, AND PANCREAS. ... THESE DIFFERENCES IN LOCALIZATION OF THALLIUM SUGGEST CAUTION IN TRANSLATING RESULTS OBTAINED IN ANIMALS TO MAN.

関連反応

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化合物ノート

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このページの内容基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
その他の操作
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EPA 2 ug/l /Thallium/
Federal Drinking Water GuidelinesEPA 0.5 ug/l /Thallium/

安全と保護具

Fire Fighting ProceduresWater, carbon dioxide, foam, dry chemical. /Soluble thallium cmpd/
Disposal Methods · 4 件

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Chemical Treatability of Thallium Concentration Process: Activated carbon; Chemical Classification: Metals; Scale of Study: Literature Review; Type of Wastewater Used: Unkown; Results of Study: GAC treatment after time precipitate yielded 84% reduction; /Soluble thallium cmpd/

Chemical Treatability of Thallium; Concentration Process: Chemical Precipitation; Chemical Classification: Metals; Scale of Study: Literature Review; Type of Wastewater Used: Unknown; Results of Study: 54% reduction with lime. /Soluble thallium cmpd/

Chemical Treatability of Thallium; Concentration Process: Chemical Precipitation; Chemical Classification: Metals; Scale of Study: Pilot Scale; Type of Wastewater Used: Synthetic wastewater; Results of Study: 30% reduction with ferric chloride, 31% reduction with aluminum (3 coagulants used: 220 ppm of alum @ pH= 6.4. 40 ppm of ferric chloride @ pH= 6.2, 415 ppm of lime @ pH= 11.5; Chemical coagulation was followed by dual media filtration.) /Soluble thallium cmpd/

Preventive Measures · 2 件

If employees' clothing may have become contaminated with soluble thallium compounds, employees should change into uncontaminated clothing before leaving the work premises. Clothing contaminated with soluble thallium compounds should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of soluble compounds from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the soluble thallium compounds, the person perfoming the operation should be informed of soluble thallium compounds's hazardous properties. Non-impervious clothing which becomes contaminated with soluble thallium compounds should be removed promptly and not reworn until the soluble thallium compound is removed from the clothing. /Soluble thallium compounds/

Skin that becomes contaminated with soluble thallium compounds should be promptly washed or showered to remove any soluble thallium compounds. Eating and smoking should not be permitted in areas where soluble thallium compound is handled, processed, or stored. Employees who handle soluble thallium compounds should wash their hands thoroughly before eating, smoking, or using toilet facilities. /Soluble thallium compounds/

Threshold Limit Values (TLV) · 3 件

0.02 [mg/m3], inhalable fraction, as Tl

8 hr Time Weighted Avg (TWA): 0.1 mg/cu m, skin. /Thallium and soluble cmpd, as Tl/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Thallium and soluble cmpds, as Tl/

Permissible Exposure Limit (PEL)0.1 [mg/m3], as Tl
Personal Protective Equipment (PPE) · 1 件

Respirator selection: 0.5 mg/cu m: Any dust and mist respirator, if not present as a fume. 1 mg/cu m: Any dust and mist respirator except single-use and quarter-mask respirators, if not present as a fume/Any supplied-air respirator. 2.5 mg/cu m: Any supplied-air respirator operated in a continuous flow mode/Any powered, air-purifying respirator with a dust and mist filter, if not present as a fume. 5 mg/cu m: Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter/Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode/Any powered, air-purifying respirator with a tight-fitting facepiece and a high-efficiency particulate filter/Any self-contained breathing apparatus with a full facepiece/Any supplied-air respirator with a full facepiece. 15 mg/cu m: Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Emergency or planned entry into unknown concentrations or IDLH conditions: Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive pressure mode/Any supplied-air respirator that has a full face piece and is operated in pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode. Escape: Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter/Any appropriate escape-type, self-contained breathing apparatus. /Thallium (soluble cmpds, as Tl/

Immediately Dangerous to Life or Health (IDLH) · 2 件

15.0 [mg/m3], as Tl (soluble compounds)

15 mg/cu m (as Tl). /Thallium (soluble cmpds, as Tl)/

毒性情報

Adverse EffectsNeurotoxin - Sensorimotor
Medical Surveillance · 1 件

The following medical procedures should be made available to each employee who is exposed to ... thallium /and thallium/ compounds at potentially hazardous levels: Initial Medical Examination: A complete history and physical examination: The purpose is to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Examination of the eyes, nervous system, lung, liver, kidneys, gastrointestinal tract, and body hair should be stressed. Urinalysis: Since kidney damage has been observed in humans exposed to thallium, a urinalysis should be obtained to include at a minimum specific gravity, albumin, glucose, and a microscopic /examination/ on centrifuged sediment. Periodic Medical Examination: These medical examinations should be repeated on an annual basis. /Thallium and thallium compounds/

Human Toxicity ExcerptsThallium is a skin sensitizer and cumulative poison which is toxic by ingestion, inhalation or skin absorption. /Soluble thallium compounds/

法規制情報

FIFRA RequirementsCancelled and suspended, all products.
Clean Water Act RequirementsToxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Thallium and cmpd/
State Drinking Water Guidelines · 2 件

(AZ) ARIZONA 13 ug/l /Thallium/

(MN) MINNESOTA 0.6 ug/l /Thallium/

Federal Drinking Water StandardsEPA 2 ug/l /Thallium/
Federal Drinking Water GuidelinesEPA 0.5 ug/l /Thallium/

安全データ

tsca
TSCA listed
有毒物質データの
16222-66-5(Hazardous Substances Data)

In acute thallium poisoning, human brain areas densely populated with neurons were found to accumulate thallium more than other areas, and the gray matter contained higher thallium levels than nonneural tissues. /Soluble thallium cmpd/

用途と製造

Uses · 2 件

Used formerly in medications; [HSDB]

MEDICATION /FORMER USE/

General Manufacturing InformationSulfuric acid, thallium(3+) salt (3:2): INACTIVE

応用分野

使用Thallium(III) Sulfate is used as an oxidizing agent.