基本情報
- CAS
16595-80-5- 標準SMILES
Cl.c1ccc([C@H]2CN3CCSC3=N2)cc1- InChIKey
LAZPBGZRMVRFKY-HNCPQSOCSA-N- 分子式
- C11H12N2S.ClH
- 平均分子量
- 240.75 g/mol
- 単同位体質量
- 240.0487973
概要
Levamisole hydrochloride is an organic molecular entity.
名称と識別子
- 優先名称
- Levamisole Hydrochloride
- IUPAC
- (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride
- 現地名
- レバミゾール塩酸塩
- 英語名
- Levamisole hydrochloride
- 分子式
- C11H13ClN2S
- 分子量
- 240.75
名称と別名
Levamisole hydrochloride16595-80-5Levamisole HClErgamisolAscaridilTramisolDecarisLevasoleSolaskilSpartakon lL-narpenolNSC-177023
名称をさらに表示
レバミゾール塩酸塩L-ナルペノールレボミソール塩酸塩リペルコルLレバミソール·塩酸塩(6S)-2,3,5,6-テトラヒドロ-6-フェニルイミダゾ[2,1-b]チアゾール·塩酸塩(6S)-6α-フェニル-2,3,5,6-テトラヒドロイミダゾ[2,1-b]チアゾール·塩酸塩シタリンLl-テトラミゾール塩酸塩塩酸レバミゾール(-)-レバミソール塩酸塩トラミソールデカリスレバミソール塩酸塩レバミソール塩酸塩標準品(S)-2, 3, 5, 6-テトラヒドロ-6-フェニルイミダゾ[2, 1-b]チアゾール及びその塩類Levamイソle 酸レバミゾール塩酸塩 [生化学用](-)-2,3,5,6-テトラヒドロ-6-フェニルイミダゾ[2,1-b]チアゾール塩酸塩(-)-テトラミゾール塩酸塩TETRAMISOLE HCLLEVAMISOL HYDROCHLORIDEcitarinlLevamisole HCILevadinDekaris
物性
構造計算による物性
- 極性表面積
- 40.9 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 2
- 回転可能結合数
- 1
- 重原子数
- 15
- 形式電荷
- 0
- 複雑度
- 246
実験および物理化学的性質
Solubility
Water 210 (mg/mL)
Methanol sol. (mg/mL)
Propylene glycol sol. (mg/mL)
Ethanol sl. sol. (mg/mL)
>36.1 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
Breast Feeding; Lactation
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal Drugs
FDA approved animal drugs -> Active ingredient
Pharmaceuticals -> UK Veterinary Medicines Directorate List
Optical Rotation(c = 1, H2O) [a]21D = - 126.2 ± 1.4°
Stability/Shelf Life
Bulk: Levamisole appears to be stable in the bulk form at 60°C for at least four weeks. Solution: At 100 mg/mL concentrations in water and pH 7 buffer, the compound is stable for at least 9 days when stored at ambient temperature under normal laboratory illumination.
Collision Cross Section143.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
物理化学的性質
- 融点
- 266 · 266-267 °C(lit.)
- 比旋光度
- -128 · -128 º (c=5, H2O)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P260, P264, P270, P273, P280, P301+P316, P318, P319, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 174 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
H301: Toxic if swallowed [Danger Acute toxicity, oral]
危険有害性情報
Regulatory Information
Chemical: Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (S)-
Levamisole hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (S)-: Environment tier I assessment
Hazard Classes and Categories
Acute Tox. 3 (100%)
Acute toxicity (Oral) - Category 3
毒性情報
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
安全データ
- F
- 10
- wgk
- 3
- rtecs
- NJ5960000
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 29349990
- risk_code
化学と産業
薬理情報
MeSH Pharmacological Classification
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
用途と製造
Use Classification
Veterinary Drug -> ANTHELMINTHIC_AGENT -> JECFA Functional Classes
Veterinary Drug -> ANTHELMINTHIC_AGENT -> JECFA Functional Classes
Veterinary Drug -> ANTHELMINTHIC_AGENT -> JECFA Functional Classes
Veterinary Drug -> ANTHELMINTHIC_AGENT -> JECFA Functional Classes
応用分野
用途薬理・生理作用研究用。
用途動物用駆虫剤、農薬（松枯れ防止剤）、免疫賦活薬。
用途残留レバミゾール定量用。
使用Levamisole hydrochloride is an anthelmintic. The activity of levamisole is about twice as high as that of abscisicidal, and the toxicity and side effects are lower. Levamisole can cause muscle paralysis of roundworms and then excrete them in the feces. It is mainly used as an anti-worm and anti-hookworm.
使用Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.
調製方法
関連反応
2 件
化合物ノート
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