基本情報
- CAS
77-39-4- 標準SMILES
OC(CCN1CCCCC1)(c1ccccc1)C1CCCC1- InChIKey
SWRUZBWLEWHWRI-UHFFFAOYSA-N- 分子式
- C19H29NO
- 平均分子量
- 287.4 g/mol
- 単同位体質量
- 287.22491455
概要
Cycrimine is a member of the class of piperidines that is 3-(piperidin-1-yl)propan-1-ol in which one of the hydrogen atoms at the 1-position is substituted by cyclopentyl, and the other is substituted by phenyl. A central anticholinergic, it is used as its hydrochloride salt in the management and treatment of Parkinson's disease. It has a role as an antiparkinson drug, a muscarinic antagonist and an antidyskinesia agent. It is a member of piperidines, a tertiary alcohol and a tertiary amino compound.
名称と識別子
- 優先名称
- Cycrimine
- IUPAC
- 1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
- 現地名
- 1-フェニル-1-シクロペンチル-3-ピペリジノ-1-プロパノール
- 英語名
- cycrimine
- 分子式
- C19H29NO
- 分子量
- 287.444
名称と別名
cycrimine77-39-4CicriminaCycriminum(+-)-cycrimine1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-olalpha-Cyclopentyl-alpha-phenyl-1-Piperidinepropanol543567RFQQCHEBI:59692DTXSID508617691-Piperidinepropanol, alpha-cyclopentyl-alpha-phenyl-RefChem:130055
名称をさらに表示
1-フェニル-1-シクロペンチル-3-ピペリジノ-1-プロパノールシクリミンα-シクロペンチル-α-フェニル-1-ピペリジン-1-プロパノール1-シクロペンチル-1-フェニル-3-(ピペリジン-1-イル)プロパン-1-オールcycrimine USP/EP/BP1-Piperidinepropanol, α-cyclopentyl-α-phenyl-α-Cyclopentyl-α-phenyl-1-piperidine-1-propanol1-Phenyl-1-cyclopentyl-3-piperidino-1-propanol1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol
DTXCID50810651alpha-cyclopentyl-alpha-phenyl-1-piperidinepropanol.HCl201-024-61-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol1-Piperidinepropanol, a-cyclopentyl-a-phenyl-1-Piperidinepropanol, .alpha.-cyclopentyl-.alpha.-phenyl-.alpha.-Cyclopentyl-.alpha.-phenyl-1-piperidinepropanolCycriminum [INN-Latin]
物性
構造計算による物性
- XLogP
- 3.9
- 極性表面積
- 23.5 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 2
- 回転可能結合数
- 5
- 重原子数
- 21
- 形式電荷
- 0
- 複雑度
- 301
実験および物理化学的性質
LogP4
Solubility9.09e-03 g/L
Melting Point112-113
Physical DescriptionSolid
物理化学的性質
- 融点
- 90 · 90-92°C
- 沸点
- 125 · 125-135 °C(Press: 0.02 Torr)
- 比重(密度)
- 1.057 · 1.057±0.06 g/cm3(Predicted)
- 貯蔵温度
- -20 °C · -20°C Freezer, Under inert atmosphere
- 溶解性
- クロロホルム（微量）、酢酸エチル、メタノール（微量）
- 外見
- 個体
- 酸解離定数(Pka)
- 14.4 · 14.40±0.29(Predicted)
- 色
- オフホワイトからペールイエロー
- 安定性
- Stable under recommended storage conditions., Stable Under Recommended Storage C
化学と産業
薬理情報
Protein Binding14-21%
Pharmacodynamics
Cycrimine is a central anticholenergic used in the treatment of the symptoms of Parkinson's disease. It is a drug used to reduce levels of acetylcholine. Acetylcholine is usually in balance with dopamine neurotransmitters, however lower levels of dopamine are present in the brain of patients suffering from Parkinson's disease. By lowering levels of acetylcholine, it is thought that this balance may be restored.
Mechanism of ActionCycrimine binds the muscarinic acetylcholine receptor M1, effectively inhibiting acetylcholine. This decrease in acetylcholine restores the normal dopamine-acetylcholine balance and relieves the symptoms of Parkinson's disease.
Cellular LocationsMembrane
応用分野
使用Cycrimine is a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.
上流・下流製品情報
上流原料
サプライヤー10 社
北京华美互利生物化工010-56205725 · [email protected]
宝鸡缔都医药化工有限公司029-81145305 17791533577 · [email protected]
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