ラニチジン塩酸塩
Ranitidine Hydrochloride
基本情報
- CAS
66357-59-3- 標準SMILES
CN/C(=C\[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1.Cl- InChIKey
GGWBHVILAJZWKJ-KJEVSKRMSA-N- 分子式
- C13H23ClN4O3S
- 平均分子量
- 350.87 g/mol
- 単同位体質量
- 350.1179395
概要
Ranitidine Hydrochloride is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.
名称と識別子
- 優先名称
- Ranitidine Hydrochloride
- IUPAC
- (E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride
- 現地名
- ラニチジン塩酸塩
- 英語名
- Ranitidine Hydrochloride
- 分子式
- C13H22N4O3S.ClH
- 分子量
- 350.87
名称と別名
ranitidine hydrochloride66357-59-3Ranitidine HCLAzantacRaniblocNu-RanitRani-QFendibinaGastridinaGastrolavKuracidAlquen
名称をさらに表示
ラニチジン塩酸塩ザンタックツルデックセオトタックラデンライタジンブラウリベラザメックラニメルク塩酸ラニチジンラニチジン·塩酸塩N-[2-[[5-[(ジメチルアミノ)メチル]フルフリル]チオ]エチル]-N'-メチル-2-ニトロ-1,1-エテンジアミン·塩酸塩ラニタックラニザックラニチザンN-[2-[[[5-[(ジメチルアミノ)メチル]-2-フラニル]メチル]チオ]エチル]-N'-メチル-2-ニトロ-1,1-エテンジアミン·塩酸塩N-[2-[5-[(ジメチルアミノ)メチル]フルフリルチオ]エチル]-N'-メチル-2-ニトロ-1,1-エテンジアミン塩酸塩ラニチジン 塩酸塩ラニチジン塩酸塩, 99%ラニチジン塩酸塩 (JP17)noctoneRanitidine HydrochloorideRANITIDINEHYDROCHLORIDE,USPRanitidine hydrochloride CRSZamec
物性
構造計算による物性
- 極性表面積
- 112 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 7
- 回転可能結合数
- 9
- 重原子数
- 22
- 形式電荷
- 0
- 複雑度
- 347
実験および物理化学的性質
Chemical ClassesOther Uses -> Pharmaceuticals
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anti-Ulcer Agents; Histamine H2 Antagonists; Gastrointestinal Agents
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 融点
- 134 °C · 134°C (dec.)
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- 2 O: · H2O: 1.8 mg/mL
- 外見
- 個体
- 酸解離定数(Pka)
- 8.27 · 8.27 (pKa2)
- 色
- タン
- 水溶解度
- 2 · 水、2-ヒドロキシプロピル-β-シクロデキストリン、酢酸、メタノール、エタノール、ジメチルスルホキシドに可溶。クロロホルムに不溶。
- Merck
- 14 · 14,8110
- BCS Class
- 3 · 3/1
- 安定性
- 吸湿性
- 主な用途
- 医薬品（低分子化合物）
- InChI
- InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;
- InChIKey
- GGWBHVILAJZWKJ-KJEVSKRMSA-N
- SMILES
- C(/NC)(\NCCSCC1OC(CN(C)C)=CC=1)=C/[N+]([O-])=O.[H]Cl
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 3.9% (3 of 76) of reports.
Danger
H315 (85.5%): Causes skin irritation [Warning Skin corrosion/irritation]
P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 76 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
危険有害性情報
Regulatory InformationRanitidine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Allergic contact dermatitis reported in pharmaceutical workers; [Kanerva, p. 1170] Ranitidine is a drug to reduce acid secretion in the stomach. Many side effects have been reported after ingestion of therapeutic doses including, rarely, drug-induced hepatitis. [HSDB]
Hazard Classes and Categories
Skin Irrit. 2 (100%)
Skin Irrit. 2 (85.5%)
毒性情報
Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Ranitidine hydrochloride
vLess-DILI-concern
5
化学と産業
薬理情報
FDA Pharmacological Classification
RANITIDINE HYDROCHLORIDE
Histamine-2 Receptor Antagonist [EPC]; Histamine H2 Receptor Antagonists [MoA]
MeSH Pharmacological Classification
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
用途と製造
UsesUse (kg) in Switzerland (2009): >1000
応用分野
用途生理・薬理作用研究用。
用途ヒスタミンH2 受容体遮断剤 です。胃粘膜のヒスタミンH2受容体を遮断し、 胃酸分泌抑制作用を示します。H2 遮断作用は シメチジンの10倍以上です。ペプシン分泌 抑制作用を有します。
用途ヒスタミンH2 受容体遮断剤 です。胃粘膜のヒスタミンH2 受容体を遮断し、 胃酸分泌抑制作用を示します。H2 遮断作用は シメチジンの10 倍以上です。ペプシン分泌 抑制作用を有します。
使用An H-2 histamine receptor antagonistRanitidine hydrochloride is mainly used as an H2-receptor antagonist and helps in the treatment of gastrointestinal lesions because of excessive gastric acid secretion. It also serves as an antiulcer drug.
関連反応
5 件
化合物ノート
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