gamma-endorphin, des-Tyr(1)-

HCID 3035192CAS 67810-56-4

基本情報

標準SMILES: CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O
InChIKey: YQEWLSJJOSZFHG-DSFKZNPVSA-N
分子式: C74H122N18O25S
平均分子量: 1,695.9 g/mol

名称と識別子

優先名称: gamma-endorphin, des-Tyr(1)-
IUPAC: (2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoic acid
英語名: GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-THR-LEU
分子式: C74H122N18O25S
分子量: 1695.93

名称と別名

Dtgammae67810-56-4(Des-tyr(1))-gamma-endorphinbeta-Lph(62-77)1-De-tyr-gamma-endorphinbeta-Lipotropin(62-77)gamma-Endorphin, des-tyr(1)-gamma-Endorphin, des-tyrosine(1)-RefChem:142297[Des-Tyr1]-gamma-Endorphin[Des-Tyr1] g-Endorphin1-De-L-tyrosine-16a-L-leucine-alpha-endorphin (sheep)

名称をさらに表示

β-lipotropin 62-77des-tyr1-γ-endorphinBETA-ENDORPHIN (2-17)BETA-LIPOTROPIN (62-77)DES-TYR1-GAMMA-ENDORPHINdes-tyr(1)-gamma-endorphi2-16-α-Endorphin (sheep), 16a-L-leucine-GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-THR-LEU

orb2645914alpha-Endorphin (sheep), 1-de-L-tyrosine-16a-L-leucineYQEWLSJJOSZFHG-DSFKZNPVSA-NHY-P10498TP2751CS-1102343H-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OH

データベース識別子

CAS: 67810-56-4
PubChem CID: 3035192
Nikkaji: J573.420G

物性

構造計算による物性

XLogP: -9.6
極性表面積: 724 Å²
水素結合供与体数: 24
水素結合受容体数: 28
回転可能結合数: 55
重原子数: 118
形式電荷: 0
複雑度: 3,390

物理化学的性質

貯蔵温度: 20 °C · −20°C
外見: Solid

安全と法規制

安全データ

wgk: 3

化学と産業

薬理情報

MeSH Pharmacological Classification · 1 件

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.

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