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基本情報
- CAS
94424-50-7- 標準SMILES
CCCN1C[C@@H](NS(=O)(=O)N(CC)CC)C[C@@H]2Cc3c(O)cccc3C[C@H]21.Cl- InChIKey
DVLKVIJLALMCBQ-MSSRUXLCSA-N- 分子式
- C20H34ClN3O3S
- 平均分子量
- 432.03 g/mol
- 単同位体質量
- 431.20094063
名称と識別子
- 優先名称
- Quinagolide hydrochloride
- IUPAC
- N,N-Diethyl-N'-[(3S,4aS,10aR)-6-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-3-yl]sulfuric diamide--hydrogen chloride (1/1)
- 現地名
- キナゴリド
- 英語名
- Quinagolide hydrochloride
- 分子式
- C20H33N3O3S.ClH
- 分子量
- 432.02
名称と別名
キナゴリド塩酸塩SDZ 205-502Norprolac HydrochlorideCV205-502 hydrochlorideQUINAGOLIDE HYDROCHLORIDEQuinagolide hydrochloride (CV205-502 hydrochloride)(3S,4aS,10aR)-3-(Diethylsulfamoylamino)-6-hydroxy-1-propyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline hydrochloriderel-N,N-Diethyl-N'-[(3R,4aR,10aS)-1,2,3,4,4a,5,10,10a-octahydro-6-hydroxy-1-propylbenzo[g]quinolin-3-yl]sulfaMide Hydrochloride(3α,4aα,10aβ)-N,N-Diethyl-N'- (1,2,3,4,4a,5,10,10a-octahydro-6-hydroxy-1-propylbenzo[g]quinolin-3-yl)sulfaMide Monohydrochloride(+/-)-N,N-diethyl-N'-quinolinyl>sulfamide hydrochloride
データベース識別子
- CAS
94424-50-7- PubChem CID
- 3086400
- DTXSID
DTXSID20241478
物性
物理化学的性質
- 融点
- 234 · 234-236°
- 貯蔵温度
- -20 °C · Store at -20°C
- 溶解性
- 43 mg/mL · DMSO : ≥ 43 mg/mL (99.53 mM)
- 外見
- Solid
- 色
- White to off-white
- CAS データベース
- 94424 · 94424-50-7(CAS DataBase Reference)
化学と産業
応用分野
説明Quinagolide is a potent and specific non-ergot dopamine D2 agonist launched in the Netherlands for the treatment of hyperprolactinemia. Quinagolide is effective in inhibiting prolactin secretion by human pituitary tumor and hyperprolactinemia in vitro and in viva A daily dose of as low as 60 pg is able to achieve a pronounced and prolonged suppressive effect on serum prolactin and growth hormone secretion. It is also effective in providing relief from associated effects such as infertility, galactorrhea, oligomenorrhea, amenorrhea, loss of IibMo and impotence. Compared with the most widely used antiprolactin, bromocriptine, quinagolide is more potent in vivo with a longer duration of action and fewer side effects. A recent study showed that acute administration of quinagolide suppresses growth hormone secretion in acromegalic patients and thus could serve as an alternative therapy in acromegaly.
使用Quinagolide is a nonergot dopamine D2-receptor agonist. Quinagolide acts as an prolactin inhibitor.
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