6-O-アセチル-1-O,3-O,4-O-トリス(2-メチル-1-オキソプロピル)-β-D-フルクトフラノシル6-O-アセチル-2-O,3-O,4-O-トリス(2-メチル-1-オキソプロピル)-α-D-グルコピラノシド

Twenty subjects (10 males and 10 females) between 18 and 22 years of age ingested a daily dose of sucrose acetate isobutyrate at a level equivalent to 10 mg/kg bw/day for a period of 14 days. The dose was taken as a bolus each morning. The following blood parameters were measured prior to treatment and at days 7 and 18 of the study: aspartate aminotransferase, alanine aminotransferase, serum alkaline phosphatase, serum bilirubin, total protein, albumin, uric acid, blood area nitrogen, erythrocyte sedimentation rate, sodium, potassium, phosphorous, total CO2, cholesterol and glucose. There were no significant differences in any parameters in any individual ... .

In another 14-day study, 12 male and 12 female subjects were divided evenly by sex into 3 groups, receiving a carbonated drink only (controls), or a single daily dose of 7.0 or 20.0 mg sucrose acetate isobutyrate/kg bw/day in a carbonated drink. In addition, four men received 20 mg sucrose acetate isobutyrate/kg bw/day for 1 or 3 days only in a pilot experiment to provide early evaluation of possible alterations in normal hepatic function. The subjects were 21 to 42 years of age. Blood was collected prior to testing and on days 7 and 14 for hematological (platelets, total and differential white blood cells count, erythrocyte sedimentation rate, Hct and hemoglobin) and clinical chemistry (total protein, albumin, A/G ratio, calcium, cholesterol, glucose, blood area nitrogen, uric acid total bilirubin, serum alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase) parameters. Standard urinalysis parameters were also recorded at these times. A 45 minute bromosulfophthalein retention test (5 mg/kg bw bromosulfophthalein was also conducte on all subjects prior to treatment and after completion of treatment. Treatment with sucrose acetate isobutyrate did not affect any of these parameters for any individual ... .

Twenty-seven adult subjects, 13 men and 14 women, between the ages of 18 to 55, received sucrose acetate isobutyrate in an aqueous/orange juice emulsion daily for 14 days at a dose of 20 mg/kg bw. In the 7 days prior to treatment, each subject acted as his/her own control by ingesting an orange juice beverage and placebo emulsion. Blood samples were collected from each subject on days -6, 0, 7 and 14 of treatment for measurement of routine hematological and clinical chemistry parameters, including specific indicators of hepatobiliary function (serum alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, gamma-glutamyl transferase, total bilirubin, direct bilirubin, bile acids and serum proteins). No treatment-related changes were detected in any of these parameters over the 14-day dosing period ... .

...95-DAY SUB-ACUTE TOXICITY TESTING OF DOGS & RATS WITH SUCROSE ACETATE ISOBUTYRATE SHOWED IT TO BE WITHOUT EFFECT.

Five groups of B6C3F1/Cr1BR mice (10/sex/group) received approx 0, 0.625, 1.25, 2.5 or 5.0 g sucrose acetate isobutyrate/kg bw/day in the diet for 4 wk. Body weights, food consumption and physical exam were recorded at initiation of treatment and weekly during the study. Feeding of sucrose acetate isobutyrate at these doses for 4 wk had no effect on the biological performance of the treated animals. No treatment-related observations were noted at the terminal necropsy ... .

A three-week feeding study was conducted in which groups of 30 Sprague-Dawley rats (15/sex/group) were fed 0, 5,000 or 50,000 ppm sucrose acetate isobutyrate in the diet. Five rats/sex/group were sacrificed after 1, 2 and 3 weeks of treatment. Twice weekly determinations of body weight and food consumption indicated no adverse effect of treatment on these parameters. Daily examination of the rats during the first week revealed a high incidence of respiratory disease which was not related to treatment; no animals died. Gross necropsy at sacrifice did not reveal any treatment-related changes. Absolute and relative liver weights were comparable between control and treated groups ... .

In a series of studies, Sprague-Dawley rats were divided into 14 treatment groups of 10 animals/sex/group and fed diets containing sucrose acetate isobutyrate at dietary levels of 1.0, 2.0 and 4.0% (w/w) supplemented with 5% corn oil (w/w). The groups were fed the test diets for 28 or 56 days continuously or for 28 days followed or preceded by 28 days on control diet. Two groups were fed the control diet containing corn oil only for 28 or 56 days continuously. At the termination of the study, animals were sacrificed and blood collected for determination of serum alkaline phosphatase (SAP), ornithine carbamyl transferase (OCT), blood urea nitrogen (BUN), triglyceride, cholesterol and glucose. The animals were autopsied, examined grossly, and absolute and relative liver weights were determined. Liver microsomal enzyme activity (p-nitroanisole demethylase), glucose-6-phosphatase and bilirubin-beta-D-glucuronyl transferase were determined and the liver was histologically examined. Weight gain and feed consumption of test and control groups were similar. There were no significant changes in the serum chemistry of the test animals. Gross pathology at autopsy was negative and liver weights (absolute and relative) were similar for test and control groups. Microsomal enzyme activity was similar for test and control animals, with the exception that glucose-6-phosphatase activity was reduced in male rats on the 4% sucrose acetate isobutyrate diet ... .

For more Non-Human Toxicity Excerpts (Complete) data for SUCROSE ACETATE ISOBUTYRATE (33 total), please visit the HSDB record page.

CIR ingredient: Sucrose Acetate Isobutyrate

Used as a modifier for lacquers, in hot-melt coating formulations, as a plasticizer (extrudable plastics), to adjust specific gravities of flavors for carbonated beverages (not approved in the US), and in citrus-flavored beverages as a substitute for brominated vegetable oils (in Canada); [HSDB] Used in cosmetics; [MSDSonline]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

USED IN CITRUS-FLAVORED BEVERAGES IN CANADA AS A SUBSTITUTE FOR BROMINATED VEGETABLE OILS AND IS PERMITTED AT LEVELS AS HIGH AS 50 PPM.

MODIFIER FOR LACQUERS, HOT-MELT COATING FORMULATIONS, EXTRUDABLE PLASTICS

Used for adjusting specific gravities of flavor oil mixtures for carbonated beverages, but not approved in the United States.

CLEAR SUCROSE DERIVATIVE AVAILABLE EITHER AS SEMI-SOLID (100%), OR AS A 90% SOLN IN ETHYL ALC.

A NAIL POLISH COMPRISES A MIXT OF SUCROSE BENZOATE, SUCROSE ACETATE ISOBUTYRATE, & IF DESIRED, A PLASTICIZER (ORG PHTHALATE, ADIPATE, OR PHOSPHATE) WHICH REPLACES THE TOLUENESULFONAMIDE-FORMALDEHYDE RESIN GENERALLY USED FOR ADHESION OF THE POLISH TO FINGER- OR TOENAIL.

Food Additives -> ADJUVANT; CLOUDING_AGENT; EMULSIFYING_SALT -> JECFA Functional Classes

Cosmetics -> Film forming; Plasticiser